Clinical trials: Tooth Disorder
Dental Caries
3-D Printed Resin Composite Versus Milled Resin Composite and Hybrid Ceramic Onlays: 2-Year Clinical Performance, Microtensile Bond Strength, Marginal and Internal Adaptation
Study Protocol Background The use of partial coverage restorations had increased significantly as a conservative alternative to full-coverage crowns, particularly in cases where the coronal tooth structure was extensively damaged…
- Trial name
- NCT07633717
- Testing
- 3D printed CAD/CAM hybrid resin onlay.Milled CAD/CAM hybrid ceramic onlay (Vita Enamic)Indirect resin composite onlay.
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Mansoura University
Malocclusion Class II, Malocclusion, Angle Class I
Effect of Early Versus Late Premolar Extraction on Orthodontic Tooth Movement
The goal of this randomized controlled trial is to evaluate whether the timing of premolar extraction affects the rate of orthodontic space closure during en-masse anterior retraction.
- Trial name
- NCT07773389
- Testing
- Early Maxillary First Premolar Extraction, Late Maxillary First Premolar Extraction
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Shifa College of Dentistry
Dental Caries
Randomized Clinical Trial of Occlusal Sealant
This study assessed long-term impact of tooth Eruption Stages (ES) on sealant retention on occlusal surfaces previously coated with intermediary bonding layer and it determined caries incidence outcome evolved.
- Trial name
- NCT02589743
- Testing
- Sealant, Adhesive and Sealant
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Endodontically Treated Teeth, Endodontical Retreatment
Broken Instrument Removal
The aims of this retrospective analysis are (1) to evaluate the success rate of a non-surgical retreatment of teeth with broken file instrument into the canal using ultrasounds, microscope and a modified spinal needle, (2) to…
- Trial name
- NCT05128266
- Testing
- Endodontical Retreatment
- Volunteers
- 161 people
- Sponsor
- Catholic University of the Sacred Heart
Dental Caries
Enamel Caries in Orthodontic Patients
This randomized double-blind two arm controlled clinical trials evaluates the hypothesis that the regular use of a tooth paste containing microcrystalline hydroxylapatite provides a caries preventive effect in caries-susceptible…
- Trial name
- ECOP (NCT02705456)
- Testing
- Tooth Brushing HA, Tooth Brushing FL
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Pulp Disease, Dental
Sodiumhexametaphosphate as Pulp Capping Material for Primary Teeth
Sodiumhexametaphosphate will be tested as pulp capping material in comparison to MTA for primary teeth pulp therapy
- Trial name
- NCT06170775
- Testing
- Pulp therapy, Sodiumhexametaphosphate, MTA
- Volunteers
- 100 people
- Sponsor
- Minia University
Pulpitis
A Clinical Trial Comparing FS With ZOE and Non-eugenol Based Materials in Primary Teeth Pulpotomies
Internal resorption in the most common cause of failure in FS pulpotomies in primary molars. This has been attributed to the release of free eugenol from the zinc and eugenol mixture of the base material over the pulp tissue.
- Trial name
- NCT05557812
- Testing
- non-eugenol based ZOE base material with Ferric Sulfate in primary molar pulpotomies, eugenol based zinc oxide and Ferric Sulfate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Edentulous Mouth
Zirconia Bars for Mandibular Implant Overdentures
Purpose: To assess the clinical and radiographic outcomes of computer-aided designed and manufactured (CAD-CAM) zirconia bars supporting mandibular implant-retained overdentures (IODs) after a 3-year follow-up.
- Trial name
- NCT06471881
- Testing
- Two mandibular implants
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dental Caries
Effectiveness of Coconut Oil Pulling With Clove Oil, Coconut Oil Pulling and Fluoride Mouthwash on Streptococcus Mutans Count in Children
This study aims to compare the effectiveness of coconut oil pulling with clove oil, coconut oil pulling alone, and fluoride mouthwash in reducing Streptococcus mutans levels in children aged 6-12 years.
- Trial name
- COPCO (NCT06902532)
- Testing
- coconut oil pulling with clove oil, coconut oil pulling, Fluoride Mouthwash
- Where
- 2 sites in Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Dental Malocclusion
Validation of Dental Malocclusion Schematic Representations for Early Orthodontic Treatment
Dental occlusion is the reciprocal confrontation of the two dental arches. The child has two set of temporary and permanent teeth and passes through different stages of dentition during which dental, skeletal or functional…
- Trial name
- CHARTE-ODF (NCT03991221)
- Testing
- Dental Exam, Orthodontics consult, Call back at 6 month
- Where
- 11 sites in France
- Volunteers
- 659 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Class II Division 1 Malocclusion
A Prospective Randomized Controlled Trial to Evaluate the Effectiveness of the Two Different Appliances in the Treatment of Class II Division 1 Malocclusion
Twin-Block treatment and Dynamax treatment for Class II division 1 malocclusion do not have different effects with regards to treatment duration, the quality of dento-occlusal outcome, skeletal and soft tissue profile, patient…
- Trial name
- NCT00957489
- Testing
- Dynamax appliance, Twin-block appliance
- Where
- 2 sites in United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Pulpitis
Evaluation of Pulpotomy Using Two Different Agents in Mature Anterior Teeth With Pulpitis
the study will evaluate the clinical and radiological success of mature permanent anterior teeth pulpotomy in children and adolescents with signs of pulpitis using two different Biomimetic materials (NeoPutty® and Biodentine™) as…
- Trial name
- NCT06468085
- Testing
- premixed Bioceramic NeoPUTTY®, Biodentine™, Root canal treatment
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries
Knowledge, Attitude, Behavior and Prevalence of Dental Caries of Rural Mothers and Their Preparatory School Young Adults in El-Sobehy Village, Fayoum, Egypt
The aim of this study is to assess prevalence of dental caries, knowledge, attitude and oral hygiene behavior of mothers and their effect on the oral health knowledge, attitude, behavior and dental caries prevalence of their…
- Trial name
- rural (NCT06749717)
- Where
- 2 sites in Egypt
- Volunteers
- 326 people
- Sponsor
- Cairo University
Fissure Sealants, Oral Hygiene Orientation
Efficacy of Sealants in Cavitated Enamel Lesions on Occlusal Surfaces in Children
The aim of this study is to evaluate the efficacy of oral hygiene orientation singly, compared to resin-based sealants in controlling occlusal cavitated enamel lesions on primary and permanent molars.
- Trial name
- SLM1661 (NCT02617940)
- Testing
- fissure sealant, oral hygiene orientation
- Where
- Brazil
- Volunteers
- 546 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Endodontic Disease
N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization
Pulp re-vascularization/regeneration is a procedure performed to allow pulpal stem cells to survive and/or differentiate to allow immature tooth root structures to grow to full maturity.
- Trial name
- NAC (NCT03451435)
- Testing
- N acetyl cysteine
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Incipient Enamel Caries, Fissure, Dental
Retention of Bonded Amalgam Sealants Versus Resin-based Sealants
Dental caries, is one of the major public health problem in Pakistan. Dental sealants are known cost effective preventive measure of dental caries as compared to other preventive measures.
- Trial name
- NCT03130725
- Testing
- Amalgam sealant, Resin based sealant
- Where
- Pakistan
- Volunteers
- 51 people
- Sponsor
- Aga Khan University
Dental Caries, Non-cavitated Occlusal Caries
Detection of Non-cavitated Occlusal Caries Lesions by Visual Inspection, LF, QLF and NILT
This study aims to evaluate and compare the diagnostic accuracy of visual examination using ICDAS-II and three adjunctive optical methods-laser fluorescence (LF), near-infrared light transillumination (NILT), and quantitative…
- Trial name
- NCT07532291
- Testing
- Diagnostic assessment of occlusal caries
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Neslihan Atmaca
Molar Incisor Hypomineralization
Glass Ionomer Cement Sealant in the Prevention of Post-eruptive Fractures in Molars Affected by MIH
This trial will compare the application of Glass Ionomer Cement (GIC) sealant with no-intervention for the most clinically- and cost-effective strategy for managing MIH molars without post-eruptive breakdown, in a school setting…
- Trial name
- MIHMex (NCT03870958)
- Testing
- GIC sealant (GC Fuji TRIAGE®), Control
- Where
- Mexico
- Volunteers
- 195 people
- Sponsor
- Isabel Cristina Olegário da Costa
Stomatognatic, Tooth Diseases
Oral Specimen and Data Acquisition Study of Subjects Requiring Third Molar Removal
Background: The third molars (wisdom teeth) normally grow in during late adolescence or early adulthood. Many people need or choose to have these teeth removed with oral surgery.
- Conditions
- Stomatognatic, Tooth Diseases, Diseases, Tooth
- Trial name
- NCT01805869
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Early Childhood Caries (ECC), Color Stability of Restoration
Evaluation of Silver Diamine Fluoride, Sodium Fluoride With Casein Phosphopeptide-Amorphous Calcium Phosphate(MI Varnish) and Dycal to Arrest Caries When Used in Indirect Pulp Capping Procedures in Children
Early childhood caries is a serious public health issue often neglected and goes untreated having detrimental effects on the child and their family. Hence, multiple teeth are affected with dental caries approaching close to pulp.
- Conditions
- Early Childhood Caries (ECC), Color Stability of Restoration, Caries Arrested, Caries,Dental
- Trial name
- SDF (NCT07893756)
- Testing
- Silver Diamine Fluoride (SDF, 38%) gel, Sodium Fluoride with CPP-ACP (MI varnish), Calcium Hydroxide (CH)
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Jazan
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