Clinical trials: Transcranial Doppler Ultrasound
Aortic Stenosis
Microembolic Signals and Serum Markers of Neuronal Damage During Transcatheter Aortic Valve Implantation.
Transcatheter Aortic Valve Implantation (TAVI) using femoral access is an option for definitive treatment of aortic stenosis when open-heart surgery is considered inappropriate.
- Trial name
- NCT01237743
- Testing
- Transcatheter aortic valve implantation.
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Sahlgrenska University Hospital
Right-to-left Shunt, Migraine
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Conditions
- Right-to-left Shunt, Migraine, Cerebral Infarction
- Trial name
- NCT02425696
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Yingqi Xing
Sickle Cell Disease, Stroke
Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the Community
The overall goal of this feasibility study is to establish a standard of care stroke prevention program for children with sickle cell anemia in a community hospital by task shifting stroke detection and transcranial Doppler…
- Trial name
- SPRING-COM (NCT05434000)
- Testing
- Hydroxyurea
- Where
- Nigeria
- Volunteers
- 217 people
- Sponsor
- Barau Dikko Teaching Hospital
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
Head Injury
Transcranial Doppler Measurement and Prognosis in Moderate Head Injury
The purpose of this study is to determine whether Transcranial Doppler measurements have correlation with neuropsychological test (Galvestone Orientation Amnesia Test), TC image (Marshall Scale) and prognosis (DRS and GOS) in…
- Trial name
- NCT00353444
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Traumatic Brain Injury
Transcranial Doppler on Admission of Patients With Mild to Moderate Traumatic Brain Injury
Patients with mild to moderate traumatic brain injury (TBI) are at risk for secondary neurological deterioration. Their outcome within the first week after injury could be predicted by clinical signs, brain CT scan and…
- Trial name
- TCD (NCT01291706)
- Testing
- Transcranial Doppler
- Where
- 21 sites in France
- Volunteers
- 369 people
- Sponsor
- University Hospital, Grenoble
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Sickle Cell Anemia
Sparing Conversion to Abnormal TCD (Transcranial Doppler) Elevation (SCATE)
The primary goal of the Phase III SCATE trial is to compare 30 months of alternative therapy (hydroxyurea) to standard care (observation) in children with sickle cell anemia and conditional (170 - 199cm/sec) Transcranial Doppler…
- Trial name
- SCATE (NCT01531387)
- Testing
- Hydroxyurea
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sickle Cell Anemia in Children
Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)
This study will 1) Evaluate the prevalence of elevated (conditional or abnormal) transcranial Doppler (TCD) velocities in a cross-sectional analysis of children with Sickle Cell Anemia (SCA) living in Tanzania; 2) Obtain…
- Trial name
- NCT03948867
- Testing
- Hydroxyurea, Elevated Arm TCD Examination, Normal Arm TCD Examination
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 202 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hemoglobinopathies
Transcranial Doppler in Children With Hemoglobinopathies
Transcranial Doppler ultrasonography (TCD) is a noninvasive, portable technique for evaluating the intracranial vasculature. TCD ultrasonography is performed placing a low frequency (≤ 2 MHz) transducer on the scalp of the…
- Trial name
- NCT04798157
- Testing
- transcranial doppler
- Volunteers
- 50 people
- Sponsor
- Sohag University
Diagnostic Value, Transcranial Doppler Ultrasound
Diagnostic Value of Transcranial Doppler Ultrasound for Evaluating Neonatal Craniocerebral Injuries
This study aims to evaluate the diagnostic value of transcranial Doppler ultrasonography (TCD) for evaluating neonatal craniocerebral injuries.
- Conditions
- Diagnostic Value, Transcranial Doppler Ultrasound, Neonatal Craniocerebral Injuries
- Trial name
- NCT07322315
- Testing
- Transcranial Doppler ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Cerebral Oxygen Saturation,MCA Velocity,Intraoperative Neurological Symptoms During Carotid Endarterectomy
Middle Cerebral Artery Velocity and Oxygen Saturation of the Brain During Carotid Endarterectomy
The primary endpoint of our study is to determine whether neurological symptoms (aphasia, paresis, loss of consciousness, numbness) occur after clamping the internal carotid artery, and if so, changes showed by transcranial…
- Trial name
- NCT02665104
- Testing
- transcranial Doppler (TCD) and INVOS monitor
- Where
- 2 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- University of Debrecen
Infant, Very Low Birth Weight, Infant, Premature, Diseases
Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants
Advances in newborn intensive care have lead to dramatic improvements in survival for the most premature infants-often weighing 1 pound at birth.
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Diseases, Cerebral Hemorrhage
- Trial name
- NCT00579943
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arkansas
Blood Disease, Anemia, Sickle Cell
Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUG
To use transcranial Doppler (TCD) ultrasound to detect stroke risk in children with sickle cell disease.
- Conditions
- Blood Disease, Anemia, Sickle Cell, Cerebrovascular Disorders, Cerebral Embolism and Thrombosis
- Trial name
- NCT00059293
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Vasospasm
Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm
The present study has been designed to assess the efficacy and safety of Stellate Ganglion Block (SGB) in relieving symptomatic cerebral vasospasm following aneurysmal clipping.
- Trial name
- NCT02775318
- Testing
- Stellate Ganglion Block, Bupivacaine, Transcranial Doppler
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Intracranial Hypertension
A Novel Non-invasive Technique of Cerebral Compliance and Auto-regulation Assessment
Introduction: Intracranial pressure (ICP) monitoring is essential in several medical situations, however, currently there is an invasive technique, costly, not widely available and sometimes contraindicated.
- Trial name
- NCT03144219
- Testing
- Transcranial Doppler (TCD) ultrasound monitoring, Non invasive intracranial compliance monitoring
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo
Sickle Cell Disease
Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound
Sickle cell disease is a life-long blood condition that can cause damage to the brain and other organs of the body. Children may develop severe, debilitating clinical states, with stroke or abnormal blood flow to the brain.
- Trial name
- NCT00152113
- Testing
- Hematopoietic Stem Cell Transplantation, CliniMACS, See intervention description
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease
Structural and functional changes in arteries are increasingly being recognized as significant features of sickle cell disease. This study aims to determine whether there are differences in arterial function parameters between…
- Trial name
- AFAT (NCT05748717)
- Where
- Jamaica
- Volunteers
- 34 people
- Sponsor
- The University of The West Indies
Sickle Cell Anemia, Cerebrovascular Accident
Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy
The aim of this study is to demonstrate that cerebral velocities assessed by transcranial doppler (TCD) are more significantly decreased by SCT than by long-term transfusion program A multicenter, national, non-randomized…
- Trial name
- DREPAGREFFE (NCT01340404)
- Testing
- Stem cell transplantation, Transfusion program
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris