Clinical trials: Transcutaneous Spinal Stimulation
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury
Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups.
- Trial name
- NCT06242873
- Testing
- Gait training with/without TSCS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Cerebral Palsy
Short-term Spinal Stimulation Effects in Cerebral Palsy
This research study will examine the acute effects of non-invasive spinal stimulation on spasticity and walking in individuals with cerebral palsy.
- Trial name
- NCT07826494
- Testing
- Spinal Stimulation, Treadmill Walking
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Spina Bifida, Myelomeningocele
tSCS in Children With Spina Bifida
A single-center, open-label, investigational pilot trial to explore potential effects of transcutaneous spinal cord stimulation on leg muscle strength and walking in children with myelomeningocele.
- Trial name
- NCT07615686
- Testing
- Transcutaneous stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bailey Petersen
Spinal Cord Injuries
Influence of Transcutaneous Spinal Stimulation Intensity on Spasticity After SCI
Transcutaneous spinal stimulation (TSS) is a form of electrical stimulation delivered over the skin of the spine that may be valuable for reducing spasticity without the side effects of antispasticity medications.
- Trial name
- NCT04243044
- Testing
- Transcutaneous spinal stimulation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Shepherd Center, Atlanta GA
Cerebral Palsy Spastic Hemiplegic
tSCS in Children and Young People With HCP
This work will examine if a technique called Transcutaneous Spinal cord stimulation (tSCS), when used with concurrent specific arm and hand exercises, helps improve arm and hand movements in CYP with HCP.
- Trial name
- NCT07247812
- Testing
- Digimer DS8R
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Leeds
Cerebral Palsy, Stroke
Spinal Stimulation and Mobility Devices
This research study will combine non-invasive spinal stimulation with an ankle exoskeleton to examine the acute impact of the stimulation on gait in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Stroke, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT05520359
- Testing
- Mobility Device, Spinal Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Cerebral Palsy, Spasticity
Spinal Cord Stimulation for Children With Cerebral Palsy
The goal of this clinical trial is to help understand spinal cord excitability in children with cerebral palsy compared to neurologically typical children.
- Trial name
- NCT07516067
- Testing
- Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martin Piazza
Spinal Cord Injury Cervical, Spinal Cord Injury, Acute
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury…
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury, Acute, Spinal Cord Injury (Quadraplegia)
- Trial name
- CIME_upperlimb (NCT07361627)
- Testing
- Protocol 2: Combination of activity-based therapy and facilitatory transcutaneous spinal cord stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injuries (SCI)
Spatiotemporal tSCS in Spinal Cord Injury
Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in…
- Trial name
- NCT07397559
- Testing
- No Stimulation, Conventional tSCS, Spatiotemporal tSCS
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Acute Spinal Cord Injury, Spinal Cord Injuries
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI).
- Conditions
- Acute Spinal Cord Injury, Spinal Cord Injuries, Neuromodulation, Traumatic Spinal Cord Injury
- Trial name
- NCT06000592
- Testing
- Digitimer
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jill M. Wecht, Ed.D.
Spinal Cord Injuries
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles.
- Trial name
- NCT04032990
- Testing
- Biostim-5 transcutaneous spinal stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Spinal Cord Injury Cervical
Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury
The main goal of this pilot study is to find the best ways to use transcutaneous spinal cord stimulation (scTS) to improve hand function in children with spinal cord injuries (SCI).
- Trial name
- NCT06489106
- Testing
- Activity based upper extremity training with and without stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training
Spinal Cord Injury (SCI) disrupts signals between the brain and the rest of the body, this includes signals needed to control the bladder and bowels.
- Trial name
- NCT05504200
- Testing
- Bladder and Pelvic Floor Muscle Training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- RNOH RIC
Neurological Disorder, Cerebral Palsy
Transcutaneous Stimulation for Neurological Populations
The purpose of the study is to evaluate whether non-invasive stimulation over the spinal cord at the neck and/or lower back can improve walking function for people with neurologic conditions.
- Trial name
- NCT04467437
- Testing
- Gait Training, Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Spinal Cord Injuries
Transcutaneous Spinal Stimulation: Safety and Feasibility for Trunk Control in Children With Spinal Cord Injury
Paralysis of trunk muscles and the inability to sit upright is one of the major problems facing adults and children with spinal cord injury (SCI).
- Trial name
- NCT03975634
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Non-invasive Spinal Stimulation as an Adjuvant Therapy for Trunk Control After Pediatric SCI
The overall purpose of this study is to test the efficacy of multi-modal training combining activity-based locomotor training and transcutaneous spinal stimulation (ABLT+scTS) to improve sitting posture and trunk control in…
- Trial name
- NCT05091463
- Testing
- Biostim-5/Neostim transcutaneous spinal stimulator
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Louisville
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Cerebral Palsy
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07433023
- Testing
- tSCS, 5-Azacitidine, Mannitol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Spina Bifida
Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder
The purpose of this research study is to determine the effectiveness of a treatment called "transcutaneous tibial nerve stimulation" or "TTNS" in the treatment of urinary leakage for patients with spina bifida.
- Trial name
- NCT06025734
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS) treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center