Clinical trials: Transfusion
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Nephrolithiasis, Pediatric Nephrolithiasis
Tubeless vs Tube PCNL in Pediatric Nephrolithiasis
This study is designed to compare two surgical techniques for removing kidney stones in children and adolescents (ages 6-18 years).
- Trial name
- TUBELESS (NCT07183930)
- Testing
- Tubeless Percutaneous Nephrolithotomy (PCNL), Standard Tube Percutaneous Nephrolithotomy (PCNL)
- Where
- Pakistan
- Volunteers
- 640 people
- Sponsor
- Lady Reading Hospital, Pakistan
Hyperbilirubinemia, Erythroblastosis, Fetal
Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease
The use of intravenous immunoglobulin G (IVIG) therapy has been reported in hyperbilirubinemia of Rh hemolytic disease but we don't have enough evidences for it.
- Trial name
- NCT00288600
- Testing
- Intravenous Immunoglobulin, Normal saline solution
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Oswaldo Cruz Foundation
Thalassemia, Sickle Cell Disease
Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused Populations
The investigators' primary objective is to study prevalences of myocardial iron overload, defined as a cardiac T2*< 20 ms, in 3 populations of multiply transfused patients, affected with thalassemia, sickle cell disease, and…
- Conditions
- Thalassemia, Sickle Cell Disease, Myelodysplasia
- Trial name
- SUFEMYO (NCT01911871)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anemia
A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia
The purpose of the study is to evaluate the efficacy and safety of luspatercept plus best supportive care (BSC) vs placebo plus BSC on anemia in adult participants with α-thalassemia hemoglobin H (HbH) disease and determine the…
- Trial name
- NCT05664737
- Testing
- Luspatercept
- Where
- 31 sites in China, Greece and 8 more
- Volunteers
- 189 people
- Sponsor
- Bristol-Myers Squibb
Impaired Oxygen Delivery, Congenital Heart Disease
Restrictive Versus Liberal Transfusion Protocol in Infants Undergoing Cardiac Surgery
In neonates and infants </= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (RBC) transfusion strategy will be as effective as, and possibly superior to, a liberal RBC strategy.
- Trial name
- NCT01484886
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Transfusion
Use of Cell Salvage Post-operatively in Infants to Decrease Use of Allogeneic Blood Product Transfusions
Transfusion of washed intra-operative cell salvage post-operatively in the PCICU can be performed safely without increased risk of bleeding or release of inflammatory mediators.
- Trial name
- cell salvage (NCT01211366)
- Testing
- Cell Saver RBCs, Conventional volume infusion
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Rochester
Hemostasis
Blood Sparing Strategies: Omni-stat Routinary Use in Cardiac Surgery. A Prospective Randomized Study.
The study enrolles all consecutive patients undergoing cardiac surgery at the European Hospital, Rome. The population undergoes randomization to receive usual surgical hemostasis or added topical application of Omni-stat Celox.
- Trial name
- NCT01008436
- Testing
- Omni-stat Celox, Control
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Cardiochirurgia E.H.
Alpha Thalassemia Major, Hemoglobinopathy; With Thalassemia
In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)
The investigators aims to evaluate the safety of in utero hematopoietic stem cell transplantation in fetuses with alpha-thalassemia major performed at the time of in utero transfusion of red blood cells.
- Conditions
- Alpha Thalassemia Major, Hemoglobinopathy; With Thalassemia, Hemoglobinopathies, Fetal Anemia
- Trial name
- NCT02986698
- Testing
- in utero hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Infant, Newborn, Infant, Low Birth Weight
The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants
This study tested the safety and efficacy of transfusing erythropoietin (Epo) and iron in infants of <1,250g birth weight. For infants 401-1,000g birth weight, we tested whether early erythropoietin (Epo) and iron therapy would…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EPO (NCT01203514)
- Testing
- Erythropoietin
- Where
- 9 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Transfusion Reaction
ABTEST© Card Clinical Perfomance Study
The study confirms the performance equivalence of the in vitro Diagnostic reagent ABTEST card used with the new reformulated WS solution
- Trial name
- NCT05140395
- Testing
- ABTEST card
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Diagast
Safety Issues, Effect of Drugs
Clinical Effect and Safety of Autologous Umbilical Cord Blood Transfusion in the Treatment of Cerebral Palsy
To study the clinical efficacy and safety of autologous umbilical cord blood transfusion in the treatment of cerebral palsy.
- Trial name
- NCT03791372
- Testing
- 0.9% Sodium Chloride, Autologous Umbilical Cord Blood
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Guangdong Women and Children Hospital
Immunoglobulins, Intravenous, Hemolysis
Isoagglutinins in the Development of IVIG-associated Hemolysis
Patients at high risk of IVIG-associated hemolysis (defined as receipt of a 28-day cumulative dose of ≥ 2 g/kg, adjusted for ideal body weight, and non-O blood group) will be prospectively monitored using a standardized protocol…
- Trial name
- NCT02259478
- Where
- 6 sites in Canada
- Volunteers
- 144 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
Severe Anaemia
Study of Safe Blood Transfusion Volumes to Correct Acute Severe Anaemia
Greater volume of whole blood(30mls/kg compared to 20mls/kg) following standard calculations, given to children with severe anaemia will be beneficial in haematological correction and can be given safely since respiratory…
- Trial name
- Tx30 (NCT01461590)
- Testing
- Whole blood
- Where
- 2 sites in Uganda
- Volunteers
- 160 people
- Sponsor
- Prof Kathryn Maitland
Jaundice Neonatal
The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion
Delayed cord clamping (DCC) has been a subject of extensive research for the last couple of years. Based on published data, numerous neonatal benefits have been suggested such as increased hemoglobin and ferritin levels both at…
- Trial name
- NCT02625688
- Testing
- Delayed cord clamping, Cord milking, Early cord clamping
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Thalassemia, Iron Overload
Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients
The safety and efficacy of CN128 is studied in thalassaemia with sever liver iron overloaded patients.
- Trial name
- NCT05355766
- Testing
- CN128 Tablets
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Hangzhou Zede Pharma-Tech Co., Ltd.
Transfusion Related Complication, Wrong Blood in Tube
Proficiency Based Training to Investigate WBIT
Incorrect labelling of blood samples occurs at a rate of 1% in the general laboratories and 6% in Blood Transfusion Laboratories.
- Trial name
- NCT03476005
- Testing
- proficiency based progression training
- Where
- Ireland
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Patrick Henn
Trauma
Rotational Thromboelastometry Activated Transfusion In Trauma Trial
This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of blood products, effects on coagulation and…
- Trial name
- ROTATE-IT (NCT03765866)
- Testing
- Thromboelastometry guided transfusion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
Anemia
The Study on Umbilical Cord Milking to Prevent and Decrease the Severity of Anemia in Preterms
The overall objective of the present study is to examine the effects of umbilical cord milking at birth in preterm infants to prevent and decrease anemia using a multi-center prospective randomized controlled trial comparing…
- Trial name
- NCT03023917
- Testing
- umbilical cord milking, umbilical cord clamping immediately
- Where
- China
- Volunteers
- 284 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Sickle Cell Disease, Thalassemia
A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease
This clinical trial is a Phase 2 study that will evaluate the safety and clinical activity of etavopivat in patients with thalassemia or sickle cell disease and test how well etavopivat works to lower the number of red blood cell…
- Trial name
- GLADIOLUS (NCT04987489)
- Testing
- Etavopivat tablets
- Where
- 32 sites in United States, Canada and 4 more
- Volunteers
- 53 people
- Sponsor
- Forma Therapeutics, Inc.