Clinical trials: Transgender Persons
HIV
MyPEEPS Mobile for Young Transgender Men
The proposed MyPEEPS intervention for young transgender men is a novel and evidence-driven intervention using mobile technology to deliver HIV prevention information to high risk youth.
- Trial name
- NCT05424718
- Testing
- MyPEEPS Mobile
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Prevention
ATN 151 Work-to-Prevent: Employment as HIV Prevention
The investigators aim to pilot-test a novel social and structural-level HIV intervention for YMSM and YTW of color ages 16-24.
- Trial name
- W2P (NCT03313310)
- Testing
- Employment Intervention
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Transgendered Persons
Trans Health: Evaluation of Markers of Cardio-metabolic Health and Well-being in Transgender Youth
This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender…
- Trial name
- NCT02550431
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Colorado, Denver
Transgender, HIV Continuum of Care
Assessing the Engagement of Transgender and Other Gender Minority Youth Across the HIV Continuum of Care
This study uses a transformative multiphasic mixed-methods research design that incorporates elements of the following designs: Sequential: a secondary data analysis was conducted, using data from ATN 039, ATN 086, and ATN 106…
- Trial name
- NCT02449629
- Where
- 14 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
PrEP2Prevent An Online PrEP Navigation and Activation Intervention
The goal of this clinical trial entitled, PrEP2Prevent: An Online PrEP Navigation and Activation Intervention for YMSM, is to develop and test a method for supporting access to an HIV prevention medication called Pre-Exposure…
- Trial name
- P2P (NCT05281393)
- Testing
- PrEPresent
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Health Services for Transgender Persons, Transgender Persons
Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents
The trial studies the efficacy of subcutaneous (SQ) testosterone compared to intramuscular (IM) testosterone therapy during the first 6 months of pubertal induction in transgender male adolescents.
- Trial name
- NCT03864913
- Testing
- Testosterone injection, PedsQL questionnarie, Masculinizing effects questionnaire
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
HIV/AIDS, Gender
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - Intervention Development
To address the critical scientific gaps in PrEP safety for transgender youth and to plan for appropriate implementation of PrEP in transgender youth communities, the study will be conducted in 3 integrated phases.
- Conditions
- HIV/AIDS, Gender, Behavior and Behavior Mechanisms
- Trial name
- NCT04077138
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hektoen Institute for Medical Research
HIV
Spurring Innovation to Promote HIV Testing: An RCT Evaluating Crowdsourcing
Crowdsourcing may be a powerful tool to spur the development of innovative videos to promote HIV testing among key populations such as men who have sex with men (MSM) and transgender (TG) individuals.
- Trial name
- NCT02248558
- Testing
- Conventional Video, Crowdsourced Video
- Where
- China
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Transgender
Body Composition Assessment in Transgender Population.
Gender-affirming hormone therapy (GAHT) is a fundamental component of medical transition in transgender men, promoting body composition changes that align physical characteristics with gender identity and alleviate gender…
- Trial name
- BIVATRANS (NCT07481942)
- Testing
- gender affirming hormone therapy
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Celia Bañuls
HIV, PrEP
Self-Consent for PrEP Perspectives
This study involves a one-time, web-based quantitative structured self-complete ("web-based") survey for all subjects and a qualitative semi-structured ("qualitative") interview for a selected sub-sample of subjects to evaluate…
- Trial name
- NCT02801760
- Where
- 11 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Prevention
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
The LifeSkills Mobile app will be evaluated in a randomized controlled trial (RCT) among 5,000 young transgender women (YTW), ages 16-29 in the United States (U.S.).
- Trial name
- LifeSkills (NCT05018611)
- Testing
- LifeSkills Mobile
- Where
- United States
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Transgender Adolescents & Young Adults
Fertility Decision-Making in Youth and Young Adults
The aim of this study is to test if using a web-based medical decision-making tool on the topics of fertility and fertility-preservation increases knowledge among transgender youth and young adults.
- Trial name
- NCT05175170
- Testing
- Decision-aid
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Acne Vulgaris
Clascoterone for Steroid-related Acne Vulgaris in Transgender Male Patients Receiving Masculinizing Hormone Therapy
Mechanism-based acne treatment for transgender patients receiving testosterone currently does not exist and is an unmet medical need. This study explores clascoterone to treat testosterone induced acne.
- Trial name
- NCT05891795
- Testing
- Clascoterone 1% Top Cream, Vehicle
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Stanford University
Gender Dysphoria, Transgender
Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2.
- Trial name
- NCT05829928
- Testing
- Infectious Disease Testing, Gonadal Tissue Removal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Contact With or Exposure to Human Immunodeficiency Virus
ImPrEP LEN Brasil: Twice-Yearly Lenacapavir for HIV Prevention
The goal of this study is to learn how well long-acting lenacapavir works to prevent human immunodeficiency virus (HIV) infection in people at higher risk of getting HIV in Brazil.
- Trial name
- ImPrEP LEN (NCT07497594)
- Testing
- Lenacapavir long-acting, Tenofovi-Emtricitabine (TDF/FTC) tablet
- Where
- 8 sites in Brazil
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Transgender Women, HIV/AIDS
Effects of Gender-Affirming Hormone Therapy Among Transgender Women
In this study, investigators plan to evaluate the cardiometabolic effects of initiating gender-affirming hormone therapy among transgender women with and without HIV.
- Conditions
- Transgender Women, HIV/AIDS, Cardiovascular Diseases, Metabolic Disease
- Trial name
- NCT04128488
- Testing
- Abdominal MR Imaging, Cardiac MRI/MRS, Oral Glucose Tolerance Testing
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gender Dysphoria
Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans
Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex.
- Trial name
- NCT06615401
- Where
- United States
- Volunteers
- 986 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Gender Dysphoria
Demographic Characteristics and Psychosocial Health of Transgender People
To study demographic characteristics of subjects referred to endocrine care for gender dysphoria and their psychosocial health
- Trial name
- DyGeDem (NCT04554849)
- Testing
- Gender dysphoria psychosocial health
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Central Hospital, Nancy, France
Gender Dysphoria, Transgender
Ovarian Tissue Cryopreservation in the Setting of Gender-affirming Therapy
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1.
- Trial name
- NCT05863676
- Testing
- Oophorectomy, Infectious Disease Testing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh