Clinical trials: Transient Elastography
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Malnutrition in Children, Liver Stiffness
Effect of Malnutrition on Liver and Spleen Stiffness in Children
This prospective observational study aims to evaluate the effect of malnutrition on liver and spleen stiffness in children using shear wave elastography.
- Conditions
- Malnutrition in Children, Liver Stiffness, Spleen Stiffness, Shear Wave Elastography
- Trial name
- SWE (NCT06932445)
- Testing
- Shear Wave Elastography
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif AĞIR
Idiopathic Toe-walking
Elastographic Assessment of Gastrocnemius Muscle Structure in Children With Idiopathic Toe Walking
Idiopathic toe walking (ITW) is a gait pattern characterized by the absence of heel strike during the stance phase and incomplete foot contact with the ground.
- Trial name
- NCT07163520
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Pregnancy Disease, Liver Diseases
Defining 'Normal' Liver Function Tests & FibroScan Values in Pregnancy
The main aim of this single-site prospective study is to use serum liver function tests and FibroScan as assessment tools to measure liver disease in pregnant women with or without liver disease at King's College Hospital.
- Trial name
- NCT03883789
- Testing
- FibroScan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Liver Cirrhosis
The Use of Fibroscan to Assess Liver Fibrosis in Patients With Cardiac Pacemakers
This study is designed to determine if the Fibroscan (Echosens, Paris), a non-invasive, ultrasound-based device used to estimate fibrosis in patients with chronic liver disease, interferes with implanted cardiac pacemaker and/or…
- Trial name
- NCT02415348
- Testing
- Fibroscan
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
NAFLD
Use of Shear Wave Elastography to Assess Non-alcoholic Fatty Liver Disease (NAFLD)
The aim of this study is to test a non-invasive imaging technique to reliably diagnose NAFLD in children and adolescents with obesity and assess the degree of fibrosis.
- Trial name
- NAFLD (NCT03587298)
- Testing
- Real-Time (Supersonic)- 2D shear wave elastography (rt-SWE)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Steatosis, Obesity
Evaluation of the Diagnostic of Hepatic Fibrosis With the in Severe Obese Patients Candidates to Bariatric Surgery
Background: The XL probe of FibroScan was recently developed to realize liver stiffness measurements (LSM) in overweight patients.
- Conditions
- Steatosis, Obesity, Fibrosis, Liver
- Trial name
- NCT03548597
- Testing
- Evaluation of the Diagnostic of Hepatic Fibrosis With the XL Probe of the Fibroscan Versus Biopsies in Severe Obese Patients Candidates to Bariatric Surgery
- Volunteers
- 132 people
- Sponsor
- European Georges Pompidou Hospital
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Elastography, Shear Wave Elastography
HIBOC = Hepatic Imaging Biomarkers in Obese Children
The goal of this prospective, diagnostic observational study is to learn about how imaging based markers for components of liver disease appear in children with obesity.
- Conditions
- Elastography, Shear Wave Elastography, Shear Wave Dispersion, Attenuation Imaging
- Trial name
- NCT06463223
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Sahlgrenska University Hospital
Spleen; Fibrosis
Optimization of Spleen VCTE Examinations with FibroScan
This is an European, prospective, interventional, and multicenter clinical investigation which main objective is to develop a spleen examination dedicated to overweight or obese patients and assess its applicability.
- Trial name
- NCT05122416
- Testing
- FibroScan examination (S), FibroScan examination (M), FibroScan examination (XL)
- Where
- 4 sites in Netherlands, Romania and 1 more
- Volunteers
- 433 people
- Sponsor
- Echosens
Total Knee Arthroplasty
Subvastus vs. Medial Parapatellar Approaches in Total Knee Arthroplasty With Quadriceps Muscle Elastography
ABSTRACT INTRODUCTION Knee osteoarthritis is a common joint pathology causing joint pain and ambulatory limitations. In primary total knee arthroplasty (TKA) surgeries, medial parapatellar (MP) and subvastus (SV) approaches are…
- Trial name
- NCT06297746
- Testing
- Subvastus approach, Medial Parapatellar approach
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University - Cerrahpasa
Single Ventricle Heart Disease
Evaluation of Fontan-associated Hepatic Stiffness and the Efficacy of Udenafil in Reducing Liver Stiffness
A study to evaluate the efficacy of MZ101 therapy in reducing liver stiffness.
- Trial name
- FALD (NCT03430583)
- Testing
- Udenafil
- Where
- 17 sites in United States, Canada
- Volunteers
- 88 people
- Sponsor
- Mezzion Pharma Co. Ltd
Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome
Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY)
ELASTOVOD is a prospective multicenter study, involving several centers of Onco-haematology in Italy. Investigators perform hepatic elastographic measurements (with Transient Elastography, ARFI or 2D-SWE) on patients undergoing…
- Conditions
- Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome, Stem Cell Transplant Complications
- Trial name
- ELASTOVOD (NCT03426358)
- Testing
- LSM assessed by Elastographic Techniques
- Where
- 37 sites in Italy
- Volunteers
- 1,101 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Treatment Outcome, Muscle Dystonia
Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study
This project will determine the feasibility and validity of measuring elbow muscle flexor stiffness in a population of patients with sub-acute severe acquired brain injury using two measurement methods, the portable spasticity…
- Conditions
- Treatment Outcome, Muscle Dystonia, Spasticity, Muscle, Muscle Tightness
- Trial name
- NCT04207632
- Testing
- Botulinum toxin type A injection
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sickle Cell Disease
Liver Fibrosis in Sickle Cell Disease
Patients with sickle cell disease many have a number of systemic complications, including liver problems. Some of these liver problems lead to liver fibrosis/cirrhosis, secondary to chronic blood transfusions.
- Trial name
- NCT02007746
- Testing
- Liver transient elastography (Fibroscan), Ferriscan, Liver biopsy in iron overloaded subjects.
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Liver Stiffness, Spleen Stiffness
Normal Pediatric Liver and Spleen SWE
This observational study aims to determine normal liver and spleen stiffness values in healthy children using shear wave elastography (SWE).
- Conditions
- Liver Stiffness, Spleen Stiffness, Shear Wave Elastography in Healthy Children, Normal Organ Elasticity
- Trial name
- SWE (NCT06930066)
- Where
- Turkey (Türkiye)
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Post-hepatectomy Liver Failure, Hepatocellular Carcinoma
Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework for Post-Hepatectomy Liver Failure Prediction
The goal of this in-silico clinical trial is to learn about the usability and clinical effectiveness of an interpretable deep learning framework (VAE-MLP) using counterfactual explanations and layerwise relevance propagation for…
- Conditions
- Post-hepatectomy Liver Failure, Hepatocellular Carcinoma, Artificial Intelligence
- Trial name
- NCT06031818
- Testing
- The explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation, The model prediction, The model prediction and the explanation of deep learning framework (VAE-MLP) , including counterfactual explanations and layerwise relevance propagation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Maastricht University
Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
Liver Disease in Urea Cycle Disorders
This is a multi-center, cross-sectional study to assess risk for liver fibrosis and hepatic injury in individuals with urea cycle disorders (UCDs) using serum biomarkers, Fibroscan, and MRE.
- Conditions
- Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency, Citrullinemia 1, ARGI Deficiency
- Trial name
- NCT04612764
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Baylor College of Medicine
Breast Neoplasms
Shear Wave Elastography Assessment of Neoadjuvant Chemotherapy Response in Patients With Invasive Breast Cancer
The aim of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to neoadjuvant chemotherapy in patients with invasive breast cancer.
- Trial name
- NCT05068999
- Testing
- shear wave elastography
- Volunteers
- 35 people
- Sponsor
- Assiut University
Non-Alcoholic Fatty Liver Disease, Childhood Obesity
Clinical Epidemiology of NAFLD in Children and Adolescents
Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly increasing alongside overweight and obesity, not only in adults but also in children and adolescents.
- Trial name
- LiverKids (NCT05526274)
- Testing
- Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP)
- Where
- Spain
- Volunteers
- 2,866 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina