Clinical trials: Transmission
Virus Disease, DNA Virus Infections
The Safety and Immunogenicity of Recombinant Hepatitis B Vaccines in the Health Neonates
The primary safety objective of this study is to assess the safety of 10 mcg recombinant hepatitis B vaccine in the Chinese health neonates.
- Conditions
- Virus Disease, DNA Virus Infections, Hepadnaviridae Infections
- Trial name
- NCT01183611
- Testing
- Experimental recombinant hepatitis B vaccine, HBIG, Active Comparator hepatitis B vaccine, Experimental recombinant hepatitis B vaccine
- Where
- China
- Volunteers
- 1,740 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Candidiasis, Esophageal, HIV Infections
Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.
To evaluate the safety and efficacy of itraconazole oral solution versus fluconazole tablets for the treatment of esophageal candidiasis in immunocompromised patients.
- Trial name
- NCT00002132
- Testing
- Itraconazole, Fluconazole
- Where
- 18 sites in United States
- Sponsor
- Janssen Pharmaceuticals
Internet Gaming Disorder
Intergenerational Transmission & IGD
This study aims to test the longitudinal association between parental IGD and adolescent IGD, after controlling for covariates at personal, interpersonal and familial levels and the mediation effects of parenting on the…
- Trial name
- NCT05289778
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 1,270 people
- Sponsor
- Chinese University of Hong Kong
Anal Cancer, Nonneoplastic Condition
Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males
RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to prevent viral infection.
- Conditions
- Anal Cancer, Nonneoplastic Condition, Penile Cancer, Precancerous Condition
- Trial name
- NCT01209325
- Testing
- quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, laboratory biomarker analysis
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 149 people
- Sponsor
- AIDS Malignancy Consortium
HIV, Sexually Transmitted Infections
Mobile Phone Text Messaging Referral
The study hypothesis is that managed referral of patients at community level (from drug stores) increases uptake of reproductive health (RH) services at dispensary and health centre levels.
- Conditions
- HIV, Sexually Transmitted Infections, Contraception, Pregnancy
- Trial name
- SMS4Health (NCT01746758)
- Testing
- SMS text messaging referral
- Where
- Tanzania
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Mpox
Monkeypox, Biology, Outcome, Transmission and Epidemiology -Prospective Follow-up of High-risk Contacts
With the MBOTE-CONTACT study, a detailed follow-up study of high-risk contacts of mpox patients will be done. The MBOTE-CONTACT study will be nested in the NIH-Funded PALM-007 clinical trial (NCT05559099) and the MBOTE project on…
- Trial name
- MBOTE-CONTACT (NCT06136117)
- Where
- Democratic Republic of the Congo
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, Mali
Background: Half of the world's population is at risk of malaria. Malaria is a disease that affects many people in Mali and other parts of Africa. It is caused by germs spread by mosquito bites. Malaria may be mild.
- Trial name
- NCT03304704
- Where
- 3 sites in Mali
- Volunteers
- 1,928 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Falciparum, Malaria, Asymptomatic Parasitaemia
MDA and Targeted Control Against Plasmodium Carriage in the Sahel
Strategies implemented since 2010 by the Senegalese National Malaria Control Program (NMCP) enabled a reduction of malaria transmission.
- Trial name
- AMARETI (NCT07281443)
- Testing
- MDA with DHAp and SLD Primaquine, Targeted control (10-24 years) during the malaria high tranmission season: behaviour, Targeted control (15-24 years) during the malaria high tranmission season: test and treat
- Where
- Senegal
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
HIV/AIDS
Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents
The study seeks to reduce HIV/AIDS-associated stigma and its negative impact on adolescent health and psychosocial well-being. This study will examine two evidence-informed interventions: 1) group cognitive behavior therapy…
- Trial name
- NCT04528732
- Testing
- Group Cognitive Behavioral Therapy (G-CBT), Multiple Family Group (MFG)
- Where
- 3 sites in United States, Uganda
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
HIV Infections
A School-Based HIV/STD Prevention Program to Reduce Risky Sexual Behaviors Among Adolescents in Liberia
This study will evaluate the effectiveness of a school-based HIV/sexually transmitted disease prevention program in reducing sexual risk behaviors of youth attending school in Liberia.
- Trial name
- NCT00698321
- Testing
- HIV/STD prevention curriculum, General health promotion curriculum
- Where
- Liberia
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Syphilis, Syphilis Infection
Retrospective Study of iStatis Syphilis Ab Test (POC)
The purpose of this retrospective clinical trial is to establish the clinical performance of the iStatis Syphilis AbTest. The data will be used to demonstrate the product is safe and effective for its intended use.
- Trial name
- NCT06367621
- Testing
- iStatis Syphilis Antibody Test
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories
HIV Infection
Impact of a Human Papilloma Virus (HPV) Vaccine in HIV-Infected Young Women
The purpose of this study is to evaluate the immunogenicity, safety, tolerability, and behavioral impact of an HPV-6, -11, -16, -18 vaccine in HIV-infected young women.
- Trial name
- NCT00710593
- Testing
- HPV vaccine for strains -6, -11, -16, and -18
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 99 people
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
Infections, Papillomavirus
Post-marketing Safety Study of Autoimmune Diseases Following Cervarix® Vaccination
The purpose of this post-marketing study is to evaluate the incidence of autoimmune diseases (AIDs) following females who have received at the least the first dose of Cervarix® as part of their routine health care.
- Trial name
- NCT01153906
- Testing
- Data collection
- Where
- United States
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age
The MONOD trial aim to evaluate the implementation of early antiretroviral treatment strategies in HIV-infected infants and assess the feasibility and efficacy of simplifying the initial proposed regimen after a successful one…
- Trial name
- NCT01127204
- Testing
- AZT-3TC-LPV/r twice a day, ABC-3TC-EFV once a day
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 161 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, Breastfeeding, Exclusive
Men's Club: Impact of Male Partner Involvement on Initiation and Sustainment of Exclusive Breastfeeding Among Postpartum Women
Breastfeeding remains the optimal mode of feeding for infants younger than six months. Exclusive Breast Feeding (EBF) among HIV-infected mothers has been shown to be associated with a sustained and significant reduction in HIV…
- Trial name
- NCT03072758
- Testing
- Men's Club
- Where
- Nigeria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
HIV Infections
Zidovudine and Lamivudine Given Once Versus Twice Daily
The purpose of this study is to see if the full daily dose of Combivir (zidovudine [ZDV]/lamivudine [3TC]) taken once a day is as effective as the usual recommended twice-a-day dose.
- Trial name
- NCT00014014
- Testing
- Lamivudine/Zidovudine
- Where
- 20 sites in United States, Puerto Rico
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Surgery
TetraGraph in Rocuronium Infusions
This is a prospective, non-blinded study to evaluate rocuronium infusion requirements using the TetraGraph Neuromuscular Transmission Monitor during surgical procedures in patients less than 18 yrs. of age.
- Trial name
- NCT06472284
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Joseph D. Tobias
Trypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense
Stop Transmission of Gambiense Human African Trypanosomiasis
This protocol describes both the epidemiological study which aims at assessing whether over a three-year period a zero prevalence can be achieved when implementing a screen \& treat approach with acoziborole, as well as a nested…
- Trial name
- STROgHAT (NCT07789743)
- Testing
- Acoziborole
- Where
- Democratic Republic of the Congo
- Volunteers
- 2,500 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Poverty, Orphaned Children
Bridges to the Future: Economic Empowerment for AIDS-Orphaned Children in Uganda
Bridges to the Future: Economic Empowerment for AIDS-Orphaned Children in Uganda, represents the first study that measures medium-term efficacy and cost-effectiveness of a family economic empowerment intervention for…
- Conditions
- Poverty, Orphaned Children, AIDS Orphans
- Trial name
- NCT01447615
- Testing
- Bridges, Bridges PLUS, Usual Care
- Where
- Uganda
- Volunteers
- 1,410 people, healthy volunteers welcome
- Sponsor
- Columbia University
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