Clinical trials: Trauma Chest
Chest Trauma
Role of HVNI in Severe Chest Trauma
to compare the respiratory complications in patient managed with high velocity nasal insufflation versus patients managed with conventional low flow oxygen in patients with severe chest trauma
- Trial name
- NCT05692076
- Testing
- High Velocity Nasal Insufflation
- Volunteers
- 86 people
- Sponsor
- Assiut University
Heart Injuries, Anthracycline
Cardiac Injury Due to Anthracycline in Paediatric Oncological Patients
The study investigates the role of echocardiography and of serum biomarkers (NT-proBNP, cardiac Troponin-I) in predicting cardiac injury in a cohort of paediatric oncological patients treated with Anthracycline chemotherapy.
- Trial name
- NCT06898320
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS Burlo Garofolo
Traumatic Thoracic Acute Spinal Cord Injury
The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
This is an HDE probable benefit, open-label, non- randomized, single-arm, multicenter study to evaluate the safety and probable benefit of the poly(lactic-co-glycolic acid)-b-poly(L-lysine) Scaffold ("Scaffold") in subjects with…
- Trial name
- NCT02138110
- Testing
- Neuro-Spinal Scaffold
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Trauma Chest, Rib Fracture Multiple
Surgical Stabilization for Rib Fractures
The purpose of this study is to compare the usual care alone to usual care plus early surgical stabilization in adult trauma patients who have been admitted with rib fractures, to evaluate for heterogeneity of treatment effect in…
- Trial name
- SSRF (NCT04081233)
- Testing
- surgical stabilization, Usual care
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Carcinoma, Non-Small-Cell Lung
IMFINZI Specific-Clinical Experience Investigation in Patients With NSCLC After Definitive Chemoradiation Therapy
To investigate the impact of presence/absence or grade of radiation pneumonitis before starting IMFINZI, on the onset of interstitial lung disease (including radiation pneumonitis) after starting IMFINZI, in the real world in…
- Trial name
- NCT03643484
- Where
- 37 sites in Japan
- Volunteers
- 634 people
- Sponsor
- AstraZeneca
Injury, Spinal Cord
Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or "Scaffold" Arm; Standard of Care or "Comparator" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates…
- Trial name
- INSPIRE 2 (NCT03762655)
- Testing
- Neuro-Spinal Scaffold
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Preparation of Internal Thoracic Artery
Low Thermal Electrosurgical Device for Atraumatic Internal Thoracic Artery Harvesting
Electrosurgery is fundamental to the precise, fast and bloodless preparation of internal thoracic artery grafts in cardiac surgery.
- Trial name
- NCT03510026
- Testing
- Low thermal device preparation
- Volunteers
- 20 people
- Sponsor
- Triemli Hospital
Trauma Chest, Pediatric ALL
Point-of-Care Ultrasound for Pediatric Thoracic Trauma: A Multi-Institutional Trial
The objective of the proposed study is to investigate the diagnostic accuracy of ED POCUS in pediatric traumatic thoracic injuries including traumatic pneumothorax, hemothorax, lung contusion, rib fractures, and pulmonary edema…
- Trial name
- NCT05025150
- Where
- United States
- Volunteers
- 1,020 people
- Sponsor
- Sutter Health
Acute Traumatic Spinal Cord Injury
Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury
The main objective of the study is the evaluation of the safety and tolerability of FAB117-HC (a medicinal product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed with H2O2, HC016…
- Trial name
- SPINE (NCT02917291)
- Testing
- FAB117-HC, Control group
- Where
- 9 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Ferrer Internacional S.A.
Pseudomonas Infection, Cystic Fibrosis
Role of Toxins in Lung Infections Caused by Pseudomonas Aeruginosa
Some bacteria that cause disease can produce toxic substances that may worsen the disease. Pseudomonas aeruginosa is a bacteria that can produce a variety of toxins and is of special interest for patients with cystic fibrosis and…
- Trial name
- NCT00027183
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Arrest
OPALS Critical Care Sub-Studies
The purpose of the study is to evaluate the incremental benefit of a full advanced life support EMS program on the outcomes of chest pain, respiratory and major trauma patients.
- Trial name
- NCT00212953
- Testing
- Advanced Life Support
- Where
- 11 sites in Canada
- Volunteers
- 21,000 people
- Sponsor
- Ottawa Hospital Research Institute
Spine Trauma (Thoracic and Lumbar)
3D Printing in Preoperative Planning in Thoracic and Lumbar Spine Trauma
Case series of 16 patients with lower lumbar or lower thoracic traumatic injuries treated with pedicle screw fixation. Patients were divided into two groups (n≈8 per group).
- Trial name
- NCT07727161
- Testing
- Spine stabilization using CT planning, Spine stabilization using 3D-printed model planning
- Where
- Czechia
- Volunteers
- 16 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Radiotherapy Side Effect, Radiation Toxicity
Curatively Intended Thoracic Reirradiation
The number of long-term lung cancer (LC) survivors increases, however many patients are diagnosed with recurrent or new thoracic cancers. High-dose reirradiation (reRT) is promising but associated with high severe toxicity rates.
- Conditions
- Radiotherapy Side Effect, Radiation Toxicity, Oncology, Lung Cancer
- Trial name
- CureLung (NCT06950073)
- Testing
- Radiotherapy
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
Chest Injury Trauma
Under Water Seal Versus Negative Pleural Suction in Chest Trauma Patients
:The investigators aim to provide trauma patient with the best and most efficient managment options and long-term stability with the least complications by comparing the effect of under water seal alone of chest tube in one…
- Trial name
- NCT04673084
- Testing
- negative pleural suction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Trauma Chest
Median Sternotomy in Penetrating Cardiac Trauma
The investigators aim to assess role of median sternotomy in penetrating cardiac trauma regarding morbidity and mortality of the patients.
- Trial name
- NCT04917198
- Testing
- median sternotomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Lung Injury, Preterm Birth
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating.
- Trial name
- POLAR (NCT04372953)
- Testing
- Positive End-Expiratory Pressure (PEEP)
- Where
- 27 sites in United States, Australia and 5 more
- Volunteers
- 906 people
- Sponsor
- Murdoch Childrens Research Institute
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
RDS of Prematurity
Sustained Lung Inflation With CPAP in Preterm Neonates (SI-CPAP)
Neonatal respiratory distress syndrome (RDS) is the most common cause of respiratory failure in the first few days in life. It is characterized by the tendency of alveoli and terminal bronchioles to collapse due to the lack of…
- Trial name
- SI-CPAP (NCT03916523)
- Testing
- Sustained lung inflation, Continuous positive airway pressure (CPAP), Mechanical ventilation
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Multiple Trauma
Thoracic Injuries in Pediatric Polytraumatized Patients: Epidemiology, Treatment and Outcome
The present study predicts that concomitant chest injuries in polytraumatized pediatric patients are a potential source of substantial morbidity and mortality.
- Trial name
- NCT02398175
- Testing
- reanimation/intubation
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna