Clinical trials: Trauma Nervous System
Mild Traumatic Brain Injury
A Prospective Study of Brain Network Activation (BNA) Changes in High School Athletes Following Concussion
The main purpose of this study is to prospectively examine changes in Brain Network Activation(BNA)following concussion in high school athletes.
- Trial name
- NCT01673464
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Injury, Brain
Use of the LOK® Robotic Gait Trainer in the Early Rehabilitation of Children After an Acquired Brain Injury (ABI)
After an acquired brain injury (ABI), children often require extensive physiotherapy (PT) to help them relearn to walk. There is promising evidence in pediatric neuro-motor conditions of the possibility for brain activation…
- Trial name
- NCT03678064
- Testing
- Lokomat
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cardiac Arrest
OPALS Critical Care Sub-Studies
The purpose of the study is to evaluate the incremental benefit of a full advanced life support EMS program on the outcomes of chest pain, respiratory and major trauma patients.
- Trial name
- NCT00212953
- Testing
- Advanced Life Support
- Where
- 11 sites in Canada
- Volunteers
- 21,000 people
- Sponsor
- Ottawa Hospital Research Institute
Concussion, Brain, Near Point Convergence
Efficacy of Brock String Therapy Post Concussion
The purpose of the proposed study is to evaluate the efficacy of Brock String therapy prescribed in the acute stage of concussion recovery can improve clinical outcomes among patients with receded near point of convergence (NPC).
- Trial name
- NCT04076657
- Testing
- Brock String Therapy, Standard of Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Pain, Postoperative, Healing Surgical Wounds
Use of Cyanoacrylate in Healing and Pain in the Palatal Donor Site of Connective Tissue Grafts
Periodontal plastic surgery has been performed successfully for a long time in the treatment of gingival recessions and mucogingival defects.
- Trial name
- NCT06116539
- Testing
- Cyanoacrylate, Suture
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alfonso X El Sabio University
Children, Lacerations
Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair
The purpose of this study is: To determine whether oral narcotic medication versus placebo improves the pain and anxiety scores for pediatric patients requiring laceration repair in the pediatric emergency department and…
- Conditions
- Children, Lacerations, Procedures, Child
- Trial name
- NCT01053637
- Testing
- hydrocodone/acetaminophen, Sugar water
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Baylor College of Medicine
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injury., Osteoporosis.
Effectiveness of Vibration and Standing Versus Standing Alone for the Treatment of Osteoporosis for People With Spinal Cord Injury.
The purpose of this study is to find out if standing and/or standing with vibration works for the treatment of osteoporosis for people with a spinal cord injury.
- Trial name
- NCT00150683
- Testing
- vibration and passive standing versus passive standing alone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Toronto Rehabilitation Institute
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
Pain, Acute
Intranasal Fentanyl Versus Oral Morphine Sulfate in the Treatment of Pain in Pediatric Trauma
Acute tramatic pain is one of main reasons for consultation in pediatric emergency departments. To manage pain quickly and effectively must be a primary outcome of the emergency department.
- Trial name
- FINDOL (NCT03063359)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Montpellier
Drug Resistant Epilepsy, Traumatic Brain Injury Without Open Intracranial Wound
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients
In patients with drug-resistant epilepsy (DRE), there may be changes at the genetic, proteomic, and metabolomic levels when comparing epileptic tissues from DRE to normal tissues in traumatic brain injury (TBI).
- Trial name
- NCT06665880
- Testing
- Routine clinical treatment
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Xuanwu Hospital, Beijing
Brain Injury, Concussion
Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion
Adolescents with concussion will be randomly assigned to a treatment group where they will receive sub-threshold exercise, or assigned to a placebo group where they will receive structured stretching exercises.
- Trial name
- NCT02710123
- Testing
- Sub-Threshold exercise prescription, Structured stretching prescription
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University at Buffalo
Concussion, Stress Disorders, Post-Traumatic
Concussion and Post Traumatic Stress in Traumatic Brain Injury
Mild brain injury or concussion affects about four million Americans each year. Some people recover completely while others, especially those with multiple concussions, develop chronic headaches, neurodegenerative diseases and…
- Trial name
- CAPIT (NCT02119533)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- NYU Langone Health
Anterior Cruciate Ligament Injuries, Muscle Weakness
Changes in the Force-velocity Relationship of Knee Muscles After ACL Reconstruction
Anterior cruciate ligament (ACL) tear is a frequent and devastating injury in sport, especially in pivoting-contact disciplines.
- Trial name
- FoVeA (NCT05712109)
- Testing
- Follow-up after Anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
Cervical Radiculopathy, Cervical Myelomalacia
Cervical Spinal Cord Signal Abnormalities in Patients With Cervical Radicular Pain
This prospective observational study aims to determine the prevalence of cervical spinal cord signal abnormalities, including myelomalacia, among adult patients presenting to a tertiary pain clinic with cervical radicular pain.
- Trial name
- CSCS (NCT07823426)
- Testing
- Clinical and Cervical MRI Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara City Hospital Bilkent
Concussion, Brain
EEG-guided Cognitive Pacing Tool During Concussion Recovery
This investigation will assess the utility of a novel wearable electroencephalography (EEG) headband linked to a mobile application to monitor cognitive activity post-concussion, and alert a patient when it is time to take a…
- Trial name
- NCT05522855
- Testing
- EEG Sensorband and mobile application
- Volunteers
- 50 people
- Sponsor
- Dr. Matthew Kennedy
Traumatic Brain Injury
Traumatic Brain Injury - Knowledge Translation
Blunt head trauma (BHT) accounts for >450,000 emergency department (ED) visits for children annually in the US. Fortunately, >95% of head trauma in children is minor in nature.
- Trial name
- TBI-KT (NCT01453621)
- Testing
- Computerized clinical decision support
- Where
- United States
- Volunteers
- 28,669 people
- Sponsor
- Columbia University
Mild Traumatic Brain Injury, Acute Brain Injury
Aerobic Exercise for Concussion
The use of aerobic exercise treatment in the chronic phase of concussion recovery is well-described in the literature but there are limited existing data on the effect of exercise treatment in the acute phase after sport-related…
- Conditions
- Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
- Trial name
- NCT02959216
- Testing
- Aerobic Exercise, Stretching Exercise
- Where
- 3 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
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