Clinical trials: Trauma-related Stressor
Post-Traumatic Stress Disorder
Role of Substance P in Post-Traumatic Stress Disorder
This study will examine the role of substance P, a chemical messenger in the brain, in post-traumatic stress disorder (PTSD), a chronic anxiety disorder.
- Trial name
- NCT00102102
- Testing
- [18F]SPA-RQ
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Posttraumatic Stress Disorder (PTSD)
Increasing Engagement in PTSD Treatment Through Patient Education and Patient Choice
The purpose of this program is to compare two different methods of matching a Veteran to a PTSD treatment.
- Trial name
- NCT01446146
- Testing
- Informed decision making
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Posttraumatic Stress Disorder, Mental Health Issue
Preventing Trauma Symptoms in the Aftermath of Sexual Abuse in Children and Adolescents in Burundi
Survivors of sexual violence are particularly vulnerable to develop psychological as well as physical health problems, Burundian children and adolescents being at elevated risk.
- Conditions
- Posttraumatic Stress Disorder, Mental Health Issue, Family Dynamics
- Trial name
- NCT05136105
- Testing
- Preventive Narrative Exposure Therapy (PreNET) family intervention
- Where
- Burundi
- Volunteers
- 150 people
- Sponsor
- University of Konstanz
Posttraumatic Stress Disorder, PTSD
D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18…
- Trial name
- NCT01157429
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tulane University School of Medicine
PTSD
Post Traumatic Stress Disorder Among VA Ambulatory Care Patients
Posttraumatic stress disorder (PTSD) occurs in response to an extreme traumatic stressor. It is estimated that as many as 1 million VA patients who were exposed to combat may have PTSD.
- Trial name
- NCT00439322
- Where
- United States
- Volunteers
- 473 people
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder
Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Chronic Posttraumatic Stress Disorder (PTSD)
Posttraumatic stress disorder occurs in patients who have experienced, witnessed or have been confronted with an event involving actual death or the threat of death, serious injury, or the threat to physical health and felt fear…
- Trial name
- NCT00001657
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety
Efficacy of a Brief Intervention to Improve Sexual and Gender Minorities' Mental Health: Randomized Controlled Trial.
Experiences of violence, from micro to physical aggressions, have a deleterious impact on mental health. According to the Minority Stress Theory, unfavorable social conditions (such as anticipated and experienced discrimination…
- Conditions
- Depression, Anxiety, Psychological Distress, Social Phobia
- Trial name
- ESCREVA-SE (NCT05349877)
- Testing
- Expressive writing, Self-affirmation
- Where
- Brazil
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Posttraumatic Stress Disorders
Propranolol Administration and Prevention of Child PTSD in Child Trauma Victims
Twenty-nine pediatric injury patients (ages 10-18) at risk for PTSD were randomly assigned to receive either propranolol or placebo in a double-blind placebo controlled design.
- Trial name
- NCT00597389
- Testing
- Inderol (propranolol)
- Volunteers
- 29 people
- Sponsor
- Kent State University
Post-traumatic Stress Disorder
Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
- Trial name
- NCT00108628
- Testing
- Imagery Rehearsal, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- US Department of Veterans Affairs
Auditory Perceptual Disorders, Stress Disorder
The Listening Project at Reiss-Davis/Vista Del Mar Child and Family Services
A research project funded by the Reiss-Davis Child Study Center of Vista Del Mar (RDCSC/VDM) will be conducted on the Vista Del Mar campus of the RDCSC/VDM to evaluate the effectiveness of the Listening Project Protocol (LPP) in…
- Trial name
- NCT02398422
- Testing
- Listening Project Protocol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of North Carolina, Chapel Hill
Post Traumatic Stress Disorder
Technology-Based Tools to Enhance Quality of Care in Mental Health Treatment
Nearly 9 million U.S. children (1 in 8) meet criteria for at least one mental health disorder at any point in time. Effective treatments exist for these disorders, but children and families who seek services rarely receive them…
- Trial name
- NCT01915160
- Testing
- eTF-CBT, TF-CBT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Psychological Trauma, Mental Health
Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies
The purpose of this study is to partner with the North Carolina Child Treatment Program (NC CTP) and the SAMHSA-funded National Child Traumatic Stress Network (NCTSN) to develop and pilot the Collaborative Organizational Approach…
- Trial name
- COAST-IS (NCT03799432)
- Testing
- COAST-IS, TF-CBT Learning Collaborative
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Post Traumatic Stress Disorder
Early Prevention of Post Traumatic Stress Disorder
Sunnybrook Health Sciences Centre is Canada's largest trauma centre, treating 1,100 patients annually. A traumatic experience can lead to post-traumatic stress disorder, which increases hospital stays, emergency visits and…
- Trial name
- NCT02004743
- Testing
- Intervention, Treatment as usual
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Sunnybrook Health Sciences Centre
Post-traumatic Stress Disorder
Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study
The purpose of this study is: (1) to examine the effectiveness of reconsolidation blockade as a treatment for trauma-related disorders, (2) to evaluate the feasibility of implementing this new treatment on a large scale in a…
- Trial name
- PARIS-MEM (NCT02789982)
- Testing
- β-adrenergic blocker propranolol, Treatment as usual
- Where
- 20 sites in France, Martinique
- Volunteers
- 364 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Stress, Psychological, Stress Disorders, Traumatic
Promoting Resiliency in Veteran Families With Young Children
Family-centered prevention services for civilian dwelling military (CDM) families \& children are rarely available in civilian communities or often framed around mental disorders and family deficits.
- Conditions
- Stress, Psychological, Stress Disorders, Traumatic, Regulation, Self, Behavior, Child
- Trial name
- FOCUS-EC (NCT04598100)
- Testing
- FOCUS-EC
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Stress Disorders, Post-Traumatic, Depression
Veteran Health Study
The purpose of The Veteran Health Study (CSP #569) is to better understand the mental and physical health of veterans as they get older.
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Diabetes, Cardiovascular Disease
- Trial name
- NCT01175629
- Where
- United States
- Volunteers
- 7,568 people
- Sponsor
- US Department of Veterans Affairs
Anxiety Disorders, Anxiety State
Intergenerational Study of War-Affected Youth
War-related violence is a leading driver of mental disorders and illness affecting children in low- and middle-income countries (LMICs).
- Conditions
- Anxiety Disorders, Anxiety State, Depressive Disorder, Mood Disorders
- Trial name
- ISWAY (NCT06440460)
- Where
- Sierra Leone
- Volunteers
- 804 people
- Sponsor
- Boston College
Post-Traumatic Stress Disorder in Children
Evaluating Effectiveness of Dyadic Prolonged Exposure on 2-4 Years Old vs. Toddler-parent Focused Treatment
Traumatic events have potentially debilitating long-lasting effects on the child's normal development and, therefore, should be effectively treated.
- Trial name
- NCT02226393
- Testing
- Prolonged exposure, Child-parent Play Therapy
- Where
- 2 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Association for Children at Risk
Auditory Perceptual Disorders, Stress Disorder
The Listening Project at the ADD Centre and Biofeedback Institute of Toronto
Purpose: A research project will be conducted at the ADD ("Attention Deficit Disorder") Centre and Biofeedback Institute of Toronto to evaluate the feasibility of the Listening Project Protocol (LPP) intervention in individuals…
- Trial name
- NCT02680730
- Testing
- Listening Project Protocol
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill