Clinical trials: Traumatic Brain Injuries
Mild Traumatic Brain Injury
A Prospective Study of Brain Network Activation (BNA) Changes in High School Athletes Following Concussion
The main purpose of this study is to prospectively examine changes in Brain Network Activation(BNA)following concussion in high school athletes.
- Trial name
- NCT01673464
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stress Disorders, Post-Traumatic, Tissue Donors
Evaluation of Post-traumatic Stress Among the Nearest Relatives of Brain-dead Organ Donors
The goal is to compare post tramautic stress between the nearest relatives of brain-dead patients who are organ donor to those of brain-dead patients who are not organ donors for medical, legal or opposition reasons.
- Conditions
- Stress Disorders, Post-Traumatic, Tissue Donors, Tissue and Organ Procurement
- Trial name
- NCT01214018
- Testing
- Questionnaires and interview
- Where
- 4 sites in France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury
Functional and MRI Evaluation of the Robot-assisted and Traditional Rehabilitation Programs on the Muscle
Walk recovery is one of the goals of rehabilitation programs in patients with acquired brain injury. Recent experiences have shown the effectiveness of rehabilitation programs including traditional physiotherapy in combination…
- Trial name
- NCT04768192
- Testing
- Physical Rehabilitation without lokomat, Physical Rehabilitation with Lokomat
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury
Kids Injury Detection Study Using the i-STAT
KIDS-STAT is a prospective study evaluating whether a rapid blood test measuring the brain injury biomarkers GFAP and UCH-L1 using the i-STAT Alinity system can help identify children with mild traumatic brain injury who do not…
- Conditions
- Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury, Head Trauma
- Trial name
- KIDS-STAT (NCT07835919)
- Testing
- i-STAT TBI Cartridge with the i-STAT Alinity System
- Volunteers
- 700 people
- Sponsor
- Children's Healthcare of Atlanta
Concussion, Mild
Reliability of Self-reported Concussion History in Current Rugby Union Players
Perhaps no issue in sports medicine has attracted so much media attention and academic interest in recent years as the potential long-term neurodegenerative sequelae of sports-related concussion on athlete's brain health.
- Trial name
- NCT03544372
- Testing
- Assessment of Concussion History using NIH Concussion History Tool
- Where
- Ireland
- Volunteers
- 63 people
- Sponsor
- University of Dublin, Trinity College
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi
Traumatic Brain Injury, Brain Injuries
Remote Ischemic Conditioning in Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death among trauma patients accounting for one-third of all trauma mortalities.
- Conditions
- Traumatic Brain Injury, Brain Injuries, Brain Trauma, Brain Injuries, Traumatic
- Trial name
- MOTION (NCT03899532)
- Testing
- Remote Ischemic Conditioning, No-Remote Ischemic Conditioning
- Where
- United States
- Sponsor
- University of Arizona
Brain Injury Traumatic Mild
Web-Based Self-Monitoring Activity-Restriction and Relaxation Training Program for Kids With Mild Traumatic Brain Injury
SMART is an interactive web-based program that will allow youth with mild traumatic brain injuries (mTBI) to monitor their symptoms and receive education on problem-solving and coping strategies.
- Trial name
- SMART (NCT03498495)
- Testing
- Self-Monitoring Activity-restriction and Relaxation Training (SMART)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Brain Injuries
Invasive and Non-Invasive Assessment of Cerebral Oxygenation in Patients With Severe Traumatic Brain Injury (TBI)
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain…
- Trial name
- NCT00703495
- Testing
- transcranial oxygen saturation measurement (INVOS Somanetics 5100C)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs. These blood clots can break off and travel through the bloodstream to the lungs causing death.
- Trial name
- OPTTTICH (NCT01589393)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Brain Injury Traumatic Mild
Evaluation of the Impact of a Dietary and Nutritional Intervention on Persistent Post-concussive Symptoms
Concussions affect thousands of Canadians every year. Although the effects are usually temporary, 10-15% of adults experience persistent symptoms likely to last several weeks or even months.
- Trial name
- NCT05589064
- Testing
- Experimental: Dietetic counseling, Active Comparator: Omega-3, vitamin D3 and creatine monohydrate, Other : Physiotherapy treatment
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Universite de Moncton
Brain Concussion, Head Injury
ReCoUPS: Post-Concussion Patient Reports
Physical and cognitive rest are recommended as treatment for concussion, but debate persists about the utility of this recommendation for patients recovering from concussion.
- Trial name
- NCT04499937
- Testing
- Streak incentive, Loss-based incentive, Flat-fee control status quo condition
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Traumatic Brain Injury
Antisecretory Factor In Severe Traumatic Brain Injury
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury.
- Trial name
- AFISTBI (NCT04117672)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Concussion, Brain
Reduction of Concussion Symptoms Through the Use of Osteopathic Manipulative Therapy
Concussion incidence in high school and collegiate sports is high, especially in football. Once diagnosed, return to play is dependent on recovery from symptoms followed by a specific protocol for clearance; the sooner the…
- Trial name
- NCT04063618
- Testing
- Osteopathic Manipulative Therapy, Standard of Care Concussion Treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Matthew T. Mcelroy, DO
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Paediatric Brain Damage, Cerebral Palsy
Transcranial Direct Current Stimulation and Gamified Rehabilitation for Upper Limb Function in Pediatric Brain Damage
The goal of this clinical trial is to acknowledge the effects of transcranial direct current stimulation as an adjuvant with gaming rehabilitation for upper limb function rehabilitation in paediatric population with…
- Conditions
- Paediatric Brain Damage, Cerebral Palsy, Paediatric Stroke, Paediatric Traumatic Brain Injury
- Trial name
- NCT06214364
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad Francisco de Vitoria