Clinical trials: Traumatic Brain Injuries
Head Injuries With Non Missile Penetrating Objjects
Non-missile Penetrating Head Trauma,Cases Registry in Sohag University Hospital
A retrospective study was done in Neurosurgery trauma unit, Sohag University. Eighteen patients reported with different mechanisms of trauma. All patients clinically tested involving neurological evaluation.
- Trial name
- trauma (NCT03768778)
- Testing
- Debridement and dural repair
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sohag University
Intensive Care Unit
Citicholine-Amantadine Trial in Traumatic Brain Injury
This randomized study aims at comparing between the effects of amantadine, citcholine and its combinations on arousal and behavioral consequences in early phase of moderate Traumatic Brain injury (TBI).
- Trial name
- NCT03430817
- Testing
- Citicholine, Amantadine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Traumatic Brain Injury
Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics
To improve patient selection for head CT, a safe and high sensitivity screening neuroimaging modality is needed. Currently many clinicians must make treatment decisions based solely on the patients clinical exam, which has low…
- Trial name
- CUPID-Peds (NCT06697808)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Wake Forest University Health Sciences
Concussion, MTBI - Mild Traumatic Brain Injury
Online Treatment Recovery Assistance for Concussion in Kids
The investigators propose to develop a software platform, OnTRACK (Online Treatment Recovery Assistance for Concussion in Kids), for children and adolescents recovering from concussion or mild traumatic brain injury (mTBI).
- Trial name
- OnTRACK (NCT05065099)
- Testing
- Online Treatment Recovery Assistance for Concussion in Kids (OnTRACK)
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- Children's National Research Institute
Traumatic Brain Injury
Development and Validation of a Prognostic Score for Early Death in Head Injury Patients.
Traumatic brain injury (TBI) is a serious condition with high morbidity and mortality. The Glasgow score alone, assessed at the initial phase, is not enough to determine the prognosis.
- Trial name
- SCORE TC (NCT02861547)
- Testing
- death
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Traumatic Brain Injury, Intracranial Hypertension
Effect of Ketamine (Ketalar) on Intracranial Pressure
Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency…
- Trial name
- NCT00437814
- Testing
- Ketamine, effect on intracranial pressure
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Trauma, Brain
(POCUS) As an Early Screening Tool for Diagnosing Skull Fractures in Children
This study aims to evaluate the accuracy of POCUS as a screening tool for early diagnosis of skull fractures in children with mild closed head injuries admitted to the emergency department.
- Trial name
- NCT05726201
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assiut University
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Mild Traumatic Brain Injury
Un-blinded Data Collection Study of Concussion Using the BrainPulse(TM)
The primary objective of this study is to collect un-blinded BrainPulse recordings from youth and adults that have a confirmed diagnosis of concussion per protocol guidelines in order to improve a concussion detection algorithm…
- Trial name
- NCT02849002
- Testing
- BrainPulse
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Jan Medical, Inc.
Brain Injuries, Traumatic
Prognostic Value of Pediatric GCS-Pupil Score in Pediatric Patients With Traumatic Brain Injury
There are studies reporting that the survival rate in pediatric patients with abnormal pupillary response is 23% and that pupillary response is effective on mortality and patient outcomes.
- Trial name
- NCT05419739
- Testing
- Glasgow coma scale
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Uludag University
Traumatic Brain Injury
Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury
A traumatic brain injury (TBI) is among the most frequent reasons for neurological impairment in young people. The investigators investigated whether vitamin B12 vs B3 therapy could reduce the severity of traumatic brain injury…
- Trial name
- NCT05958277
- Testing
- Vitamin B3, Vitamin B12
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- KRL Hospital, Islamabad
Brain Injuries, Brain Ischemia
Evaluation of Patients Affected by Traumatic and Hypoxic-ischemic Brain Injury
According to the World Health Organization, perinatal asphyxia is the leading cause of severe neurological disabilities and the second leading cause of neonatal death among term infants, with an incidence of 3.94-5.12 per 1,000…
- Trial name
- PETRA (NCT06873477)
- Testing
- Gross Motor Function Classification System
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Concussion, Brain, Traumatic Injury
Sport Concussion Performance-Based Prevention Program
Sport-related concussions and traumatic lower body injuries (e.g., anterior cruciate ligament (ACL) tears) occur frequently in high-speed and contact/collision sports contributing to significant time loss from…
- Trial name
- NCT04992130
- Testing
- Pre-season supplementary neurologic training program
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Traumatic Brain Injury
Comparison of Brain Network Activation (BNA™) Analysis, Clinical Symptoms and Neuro-cognitive Performance in Concussed Children and Young Adults
The use of Event Related Potentials (ERP) and neurocognitive performance in patients following concussion has been examined previously in small cohorts and relatively long after concussion occurred.
- Trial name
- NCT01532271
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Mild Traumatic Brain Injury
SSVEP Evaluation of Brain Function (PRO)
The investigational device used in this clinical investigation, the Nurochek PRO System (NCPRO), is a portable electroencephalogram (EEG) headset which delivers a visual stimulus and measures a VEP.
- Trial name
- NCT06013566
- Testing
- SSVEP
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Headsafe MFG
Minor Head Injury
Influence of Cognitive Rest on Minor Traumatic Brain Injury
Background: Head injury is a common presentation to family medicine clinics and emergency departments (EDs), and the majority will not result in intracranial injury requiring neurosurgical consultation, but will have symptoms of…
- Trial name
- NCT02116673
- Testing
- Cognitive rest, Usual care
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Mount Sinai Hospital, Canada
Pressure Ulcer
Effectiveness of Freedom Bed Compared to Manual Turning in Prevention of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and/or Spinal Cord Injury.
Observational comparison on Incidence of Pressure Injury between the Freedom Bed Automated Continuous lateral Rotation Therapy System and Manual Caregiver Re-positioning every 2 hours on a standard Hospital Bed.
- Trial name
- NCT03048357
- Testing
- Freedom Bed, Standard hospital bed
- Volunteers
- 8 people
- Sponsor
- Northeast Center for Rehabilitation and Brain Injury
Concussion, Mild, Concussion; Eye
EYE-SYNC Concussion Classification Study
The purpose of this study is to determine the sensitivity and specificity of an aid in assessment of concussion based on eye-tracking, in comparison to a clinical reference standard appropriate for sport-related concussion…
- Conditions
- Concussion, Mild, Concussion; Eye, Concussion, Brain, Concussion, Severe
- Trial name
- NCT04381767
- Testing
- EYE-SYNC
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- Sync-Think, Inc.
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital