Clinical trials: Traumatic Brain Injuries
Brain Injuries, Traumatic
Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents
The study will enroll children and adolescents (0 - 17 years) suspected of having concussion or mild traumatic brain injury (TBI).
- Trial name
- NCT04288167
- Testing
- Sample collection
- Where
- Finland
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Traumatic Brain Injury, Subarachnoid Hemorrhage
Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
This study performs assessments of pituitary functions by basal hormone levels in the acute phase after TBI and/or SAH followed by detailed endocrine tests (insulin-induced hypoglycemia or growth hormone releasing…
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Hypopituitarism
- Trial name
- NCT00507104
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)
It is a "proof of concept" study, aimed to evaluate whether the "optimal CPP", defined by the best PRx, corresponds to the acceptable CBF values in patients affected by CBF disfunction caused by TBI or SAH.
- Trial name
- NCT00807833
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Brain Concussion, Mild Traumatic Brain Injury
A Study on the Effect of Mindfulness-based Yoga on Youth With Persistent Concussion Symptoms
Mild traumatic brain injury (mTBI), also known as concussion, is of great concern in the youth population, with incidences of injury steadily increasing within the past few years.
- Trial name
- NCT03217695
- Testing
- Mindfulness-based Yoga Arm
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Brain Injuries
Youth Soccer Header Study
This study aims to establish and validate age-based head kinematics, force-strain models and brain injury probability maps from sensor worn data during soccer heading tasks.
- Trial name
- NCT04919707
- Testing
- Header Session, MRI Session
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Intracranial Hypertension
Non-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients
The purpose of this study is to prospectively evaluate the accuracy and safety of non-invasive intracranial pressure (ICP) measurements using the HeadSense-1000 (HS-1000) device compared to the current invasive external…
- Trial name
- NCT02695264
- Testing
- HS-1000 recording
- Where
- United States
- Sponsor
- HeadSense Medical
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Stress Disorders, Post-Traumatic
Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder
This study, conducted at the University of Pennsylvania and at the National Institutes of Health in Bethesda, Maryland, will examine deficits in brain structure and function in people exposed to trauma who developed…
- Trial name
- NCT00069225
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Traumatic Brain Injury
Safety Study of Umbilical Cord Blood To Treat Pediatric Traumatic Brain Injury
The purpose of this study is to determine if it is safe to use stored autologous Human Umbilical Cord Blood (hUCB) to treat pediatric patients that sustain a severe or moderate Traumatic Brain Injury (TBI), and have not fully…
- Trial name
- NCT01251003
- Testing
- Autologous cord blood
- Where
- United States
- Sponsor
- Charles Cox
Concussion
Trial of Aerobic Treadmill Exercise Treatment for Concussion
A post-concussion syndrome (PCS) diagnosis has historically led to a recommendation of continued mental and physical rest to minimize symptoms.
- Trial name
- NCT02674620
- Testing
- Aerobic Exercise
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Panam Clinic
Traumatic Brain Injury
Defining Axonal Injury in Children With Mild Traumatic Brain Injury
To measure Axonal Injury in children with mild traumatic brain injury enrolled in an Emergency Department using Diffusion Tensor Imaging, a type of MRI and biomarkers.
- Trial name
- NCT01922531
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury, Intracranial Hypertension
A Non-invasive Intracranial Pressure (nICP) Monitoring System
Researchers have developed a probe that contains infrared light sources that can illuminate the deep brain tissue of the frontal lobe.
- Trial name
- NCT05632302
- Testing
- nICP
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Crainio Ltda
Brain Injury, Traumatic
Mild Traumatic Brain Injury Registry
The purpose of the study is to gather information about patients with mild traumatic brain injury in order to develop guidelines for evaluation and treatment.
- Trial name
- mTBI (NCT01688869)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Concussion, Brain
Postural Control in Children and Adolescents After Suffering From a Concussion
Sport-related concussions occur during different types of sport and are still an underestimated brain injury. Especially children are affected due to their lacking movement control and thereby at higher risk of situations leading…
- Trial name
- NCT03575741
- Testing
- Balance Tests
- Where
- Austria
- Sponsor
- Universitaet Innsbruck
Chronic Traumatic Encephalopathy
18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy
This study will explore the use of flortaucipir as a biomarker for chronic traumatic encephalopathy (CTE) and examine the relationship between clinical presentation and tau deposition.
- Trial name
- NCT02079766
- Testing
- florbetapir F 18, Flortaucipir F18
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Traumatic Brain Injury, Acquired Brain Injury
Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation
This study evaluates the validity of an intravascular continuous glucose monitoring microdialysis probe, and compares the values to routinely inserted cerebral glucose microdialysis to evaluate the hypothesised relationship…
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT03246607
- Testing
- MicroEye & ContinuMon
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dr Andrew Stevens
Concussion, Mild
Delivery of Digital Cognitive Behavioural Therapy Following Concussion
Concussion is common and patients can go on to suffer with a constellation of symptoms which impacts their functional outcome and quality of life.
- Trial name
- HEADON (NCT05069948)
- Testing
- HeadOn
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Traumatic Brain Injury
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).
- Trial name
- TXA (NCT01990768)
- Testing
- 1 gram Tranexamic Acid (TXA), 2 grams TXA, 0.9% Sodium Chloride injectable
- Where
- 12 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- University of Washington
Hemorrhagic Shock, Traumatic Brain Injury
Hypertonic Modulation of Inflammation Following Injury
This project seeks to determine the effect of prehospital resuscitation with hypertonic saline vs. conventional crystalloids on the inflammatory response after injury.
- Trial name
- NCT00750997
- Testing
- hypertonic saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 119 people
- Sponsor
- University of Washington
Concussion
Vascular Assessment of Regulation Index Arrays Registry
The objective of this patient registry is to collect and analyze physiological data associated with baseline and brain injury identified in standard clinical practice (Normal Values, Recovery Curves, Correlation between Symptoms…
- Trial name
- VARIA (NCT02435082)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroChaos Solutions, Inc.