Clinical trials: Treated Hypertension
Liver Transplantation
Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this…
- Trial name
- NCT07247877
- Volunteers
- 396 people
- Sponsor
- Zhi-Jun Zhu
Pulmonary Arterial Hypertension
Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients
Previous studies suggest that combinations of existing therapies may be effective for pulmonary arterial hypertension (PAH). However, all of these studies are sequential combination therapy, for example, by adding sildenafil to…
- Trial name
- BIPH (NCT01712997)
- Testing
- Iloprost, Bosentan
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Air Force Military Medical University, China
Primary Open Angle Glaucoma
Transconjunctival Needling Revision Versus Medical Treatment
When the glaucoma filtering surgery failures (intraocular pressure rises again), the options is start to use the hypotensive eye drops again (medical treatment).
- Trial name
- NCT01887223
- Testing
- Transconjunctival needling revision, Medical treatment
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Primary Congenital Glaucoma, Pediatric Glaucoma
Subscleral Trabeculectomy With Inverted T-Shaped Deep Sclerectomy for Primary Congenital Glaucoma
Primary congenital glaucoma (PCG) is a vision-threatening disorder of childhood characterized by elevated intraocular pressure (IOP) resulting from developmental abnormalities of the anterior chamber angle.
- Conditions
- Primary Congenital Glaucoma, Pediatric Glaucoma, Intraocular Pressure
- Trial name
- TDS-PCG (NCT07701278)
- Testing
- Subscleral Trabeculectomy Combined With Inverted T-Shaped Deep Sclerectomy
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Benha University
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pulmonary Hypertension, Pulmonary Arterial Hypertension
The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain
Subcutaneous treprostinil (Remodulin) is effective therapy for pulmonary arterial hypertension, a life threatening disease of the lung blood vessels.
- Trial name
- NCT01260454
- Testing
- Qutenza (8% capsaicin)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Sickle Cell Disease, Pulmonary Hypertension
Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension
The goal of this study is to test the hypothesis that hydroxyurea is effective for the specific treatment of secondary pulmonary hypertension found on screening in children and young adults with sickle cell disease.
- Trial name
- NCT00350844
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Portal Vein, Cavernous Transformation Of, Hypertension, Portal
Interventional Radiology for the Treatment of Symptomatic Portal Hypertension in Patients With Cavernous Transformation of Portal Vein
To evaluate the values of portosystemic shunt and other interventional radiology approaches for treatment of symptomatic portal hypertension in patients with cavernous transformation of portal vein.
- Trial name
- NCT02504034
- Testing
- Transhepatic portosystemic shunt, 6-French sheath, 22-gauge chiba needle
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Glaucoma; Drugs
Evaluation of Adherence to Clinical Treatment of Glaucoma
Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.
- Trial name
- NCT03338088
- Where
- 2 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto de Olhos de Goiania
Childhood Glaucoma
Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma
Objectives: The study will assess the ocular hypotensive effect of latanoprost and dorzolamide in a selected sample of patients affected by primary Pediatric Glaucoma (PG), refractory to surgical procedures.
- Trial name
- NCT01527682
- Testing
- Latanoprost, Dorzolamide
- Where
- 2 sites in Italy
- Volunteers
- 37 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Pulmonary Hypertension
Inhaled Iloprost for the Treatment of Persistent Pulmonary Hypertension in the Term and Near Term Infants.
Inhaled Iloprost will be administered to near term infants with Persistent Pulmonary Hypertension of the Newborn in two different doses in order to test safety and efficacy in reducing pulmonary artery pressure.
- Trial name
- NCT00409526
- Testing
- Inhaled Iloprost
- Where
- 2 sites in United States, Israel
- Volunteers
- 1 people
- Sponsor
- University of Chicago
Pulmonary Hypertension
FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)
This study was an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who were currently receiving approved therapy for their PAH (i.e., endothelin receptor antagonist and/or…
- Trial name
- NCT00325442
- Testing
- Oral treprostinil (UT-15C) sustained release tablets
- Where
- 72 sites in United States, Australia and 12 more
- Volunteers
- 354 people
- Sponsor
- United Therapeutics
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia
Inhaled nitric oxide (iNO) is an effective treatment for pulmonary hypertension (PH) in term and near-term infants. Preterm infants are at risk for early PH that is associated with high risk for bronchopulmonary dysplasia or…
- Trial name
- NCT03576885
- Testing
- inhaled nitric oxide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AdventHealth
Eye Diseases
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute…
- Trial name
- NCT00076271
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Eye Institute (NEI)
Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure
Post Market Clinical Follow-up to Assess the Portable Nitric Oxide Generation and Delivery System (INOwill N200) for the Treatment of Neonatal Hypoxic Respiratory Failure Complicated by Pulmonary Hypertension
Title : A multicenter clinical trial of the portable nitric oxide generation and delivery system (INOwill N200) for the treatment of neonatal hypoxic respiratory failure complicated by pulmonary hypertension Investigational…
- Trial name
- iNOwill Neonat (NCT07837921)
- Testing
- Nitric Oxide Generator and Delivery System
- Volunteers
- 50 people
- Sponsor
- Novlead Inc.
Glaucoma, Ultrasound Cyclo Plasty
Comparison of Cytokines Profile in Aqueous Humor and Tear Before and After UCP Treatment
Glaucoma is the leading cause of irreversible vision loss in people aged 50 years and older worldwide, second only to cataracts. Ultrasound Cyclo Plasty was first proposed as a new minimally invasive technique in the 1980 s.
- Conditions
- Glaucoma, Ultrasound Cyclo Plasty, Aqueous Humor, Tear
- Trial name
- NCT06243497
- Testing
- Ultrasound CycloPlasty
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Hypertensive Disorders of Pregnancy, Preeclampsia
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy…
- Conditions
- Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- ASPIRIN (NCT06468202)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- 20 sites in United States
- Volunteers
- 10,742 people
- Sponsor
- Ohio State University
Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn
Nebulized MgSO4 in Persistent Pulmonary Hypertension of Newborn
The aim of this pilot randomized controlled blinded study is to evaluate the feasibility of using nebulized magnesium sulfate in the treatment of PPHN.
- Conditions
- Persistent Fetal Circulation, Persistent Pulmonary Hypertension of the Newborn, PPHN
- Trial name
- NebMag (NCT04328636)
- Testing
- Nebulized Magnesium Sulfate, Intravenous Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Sohag University
Hypertension, Renal Transplant
Allopurinol for Renal Transplant Associated Hypertension in Children
To test the hypothesis that lowering serum uric acid will ameliorate hypertension in children after renal transplantation.
- Trial name
- NCT00288171
- Testing
- Allopurinol
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Preeclampsia
Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)
Introduction: Hypertensive emergency in pregnant women with pre-eclampsia should be treated for preventing stroke and placental abruption.
- Trial name
- METILDOPAPE (NCT01361425)
- Testing
- methildopa
- Where
- 2 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute