Clinical trials: Treatment Resistant Depressive Disorder
Adolescent Depression
Repetitive Transcranial Stimulation (rTMS) for Resistant Depression in Adolescents
The investigators hypothesis that repetitive transcranial Stimulation (rTMS) is a safe and effective add-on therapy for resistent depression in adolescent patients.
- Trial name
- NCT01170520
- Testing
- repetitive transcranial Stimulation
- Where
- 2 sites in Israel
- Volunteers
- 24 people
- Sponsor
- Shalvata Mental Health Center
Depression, Treatment Resistant Depression
Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and…
- Conditions
- Depression, Treatment Resistant Depression, Mood Disorders, Bipolar Disorder
- Trial name
- SHAKTI (NCT06002204)
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Major Depressive Disorder
Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The purpose of this study is to see if creatine, which is a naturally occurring chemical in the body, is effective for treating Major Depressive Disorder (MDD) in female teenagers.
- Trial name
- NCT01601210
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Perry Renshaw
Depressive Disorder, Treatment-Resistant
An Epidemiology Study of Treatment Resistant Depression in the United States (US)
The purpose of this study is to describe the epidemiology of Treatment Resistant Depression (TRD) in the US, including the population incidence of TRD, and TRD as a proportion of Pharmacologically Treated Depression (PTD), and…
- Trial name
- NCT03109002
- Volunteers
- 200,000 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder (MDD), Depression - Major Depressive Disorder
Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
This study will evaluate the efficacy and safety of a theta burst stimulation (TBS) protocol of repetitive transcranial magnetic stimulation (rTMS) in adults with treatment-resistant depression.
- Trial name
- NCT07529574
- Testing
- antidepressant therapy, Active rTMS Theta Burst Stimulation
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Jung-Sun Lee
Treatment Resistant Depression, Transcranial Magnetic Stimulation
rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism
Study of individualized accurate targeting rTMS intervention on motivational anhedonia of treatment resistant depression and brain network mechanism
- Conditions
- Treatment Resistant Depression, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging, Event-Related Potentials
- Trial name
- rTMS (NCT03991572)
- Testing
- repeated transcranial magnetic stimulation with real coil
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University
Depression, Depressive Disorder, Major
Comparing the Efficacy of Accelerated vs. Standard fMRI-guided iTBS in Treating Adolescents Depression
Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS), a type of rTMS, is a very promising new treatment for major depression in adults and…
- Trial name
- NCT06528938
- Testing
- Theta Burst Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Treatment-Resistant Depression, Major Depressive Disorder
Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression
An observational-comparative study, without interfering with the treatment, based on an operationalized interview.
- Trial name
- NCT06232291
- Where
- Poland
- Volunteers
- 3 people
- Sponsor
- Medical University of Gdansk
Major Depression
Effects of ECT on Monoamine Oxidase A in Depression Investigated With PET
This study aims at evaluating the effect of electroconvulsive therapy in treatment-resistant depressed patients on the major serotonin degrading enzyme in the human brain using neuroimaging methods, the monoamine oxidase A.
- Trial name
- NCT02379767
- Testing
- Electroconvulsive therapy, Positron emission tomography of the brain using [11C]harmine, Structural magnetic resonance imaging
- Where
- Austria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
ASD, Autism Spectrum Disorder
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
- Conditions
- ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder
- Trial name
- RETSORE-RCT (NCT06670040)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Autism Spectrum Disorder, Major Depressive Disorder
Transcranial Magnetic Stimulation for Depression in Autism Spectrum Conditions
In this research study the investigators aim to learn more about the therapeutic effects of a newer form of non-invasive transcranial magnetic stimulation (TMS), called theta burst simulation (TBS), on refractory depression in…
- Trial name
- RESTORE (NCT05271357)
- Testing
- Bilateral TMS, Unilateral TMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Unipolar Depression
Ketamine Trial for the Treatment of Depression
This study is a Randomized Controlled Trial, investigating the safety and efficacy of administration of ketamine as a potential treatment for depression.
- Trial name
- NCT02401139
- Testing
- Ketamine
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
Treatment Resistant Depression
Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression
Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there remain a subset of patients who are treatment resistant.
- Trial name
- NCT06953362
- Testing
- Direct Neural Electrical Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Bipolar Disorder
Clinical Trial of Felbamate for Treatment-Resistant Bipolar Depression
The purpose of this study is to evaluate the safety and effectiveness of the drug felbamate for treating depression in patients with bipolar disorder that has not responded to standard treatments.
- Trial name
- NCT00034229
- Testing
- Felbamate
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Mental Health (NIMH)
Insulin Resistance, Depression
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group…
- Conditions
- Insulin Resistance, Depression, Depressive Disorder, Mood Disorders
- Trial name
- CBTeX (NCT05543083)
- Testing
- Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Depression, Electroencephalography
Intermittent Theta Burst Stimulation on Anhedonia in Depression
Study comparing the efficacy of two TMS patterns (intermittent theta-burst stimulation, iTBS, and repetitive transcranial magnetic stimulation, rTMS) in treating anhedonia and their associated brain network mechanisms.
- Conditions
- Depression, Electroencephalography, Transcranial Magnetic Stimulation
- Trial name
- NCT06552026
- Testing
- repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Anhui Medical University
HIV, Metabolic Syndrome
Comorbidities and Virologic Outcome Among Patients on Anti-retroviral Therapy in Rural Lesotho
This study is conducted in a cohort of HIV-positive patients on first-line anti-retroviral therapy (ART) in rural health facilities in Lesotho, Southern Africa.
- Conditions
- HIV, Metabolic Syndrome, Depression, Alcoholism
- Trial name
- NCT02126696
- Where
- 2 sites in Lesotho
- Volunteers
- 1,754 people
- Sponsor
- Swiss Tropical & Public Health Institute
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)