Clinical trials: Treatment With Proton Beam Radiation Therapy
Central Nervous System
Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy
This study will explore neurocognitive performance in pediatric brain tumor patients receiving proton beam radiation therapy (PBRT).
- Trial name
- NCT02559752
- Testing
- NIH Toolbox Cognitive Battery
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Dysphonia
Dietary Control Alone Versus Dietary Control Plus Use of Proton Pump Inhibitors to Treat Pediatric Hoarseness
This study will examine whether lansoprazole (Prevacid) and dietary control versus dietary control alone will improve pediatric hoarseness symptoms.
- Trial name
- NCT00637416
- Testing
- Lansoprazole
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Kansas Medical Center
Pediatric Central Nervous System Tumors, Medulloblastoma
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors
his is a single-center, prospective observational study in children and adolescents with central nervous system tumors who need whole-brain and whole-spine radiation therapy (craniospinal irradiation, CSI).
- Conditions
- Pediatric Central Nervous System Tumors, Medulloblastoma, Germinoma, Ependymoma
- Trial name
- VBS-CSI-PT-PED (NCT07589361)
- Testing
- Vertebral Body-Sparing Craniospinal Proton Irradiation
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Gastroesophageal Reflux Disease, Gastrointestinal Infections
LGG for Prevention of Infectious Complications During PPI Treatment in Children
Background: Proton pump inhibitors (PPI) are effective for treating gastroesophageal reflux disease (GERD). However, they may be associated with an increased risk of gastrointestinal and respiratory tract infections.
- Conditions
- Gastroesophageal Reflux Disease, Gastrointestinal Infections, Respiratory Tract Infections
- Trial name
- NCT01782118
- Testing
- Lactobacillus GG
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Warsaw
Hearing Loss
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation
Disequilibrium between acid and base in the inner ear was suggested to be an important factor leading to hearing impairment associated with SLC26A4 mutations.
- Trial name
- NCT00789061
- Testing
- Proton pump inhibitor
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Prostate Cancer Patients Treated by Radiotherapy
Two-fraction Proton Therapy With MRI Guidance for Prostate Cancer: A Phase II Trial
This study is testing a shorter treatment method for prostate cancer using proton therapy (PT), which is very precise and may cause fewer side effects compared to traditional radiation.
- Trial name
- PT2 (NCT07130682)
- Testing
- Pencil Beam Proton Therapy Treatment Machine
- Where
- Hong Kong
- Volunteers
- 35 people
- Sponsor
- Hong Kong Sanatorium & Hospital
Prostate Cancer
Radiation Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of conventional radiation therapy with high-dose radiation therapy in treating men with…
- Trial name
- NCT00002703
- Testing
- high-LET heavy ion therapy, low-LET photon therapy
- Where
- 2 sites in United States
- Volunteers
- 390 people
- Sponsor
- Proton Radiation Oncology Group
Proton Pump Inhibitors, Human Gastrointestinal Tract
Intestinal Microbiota After PPI Treatment
This clinical study aims to investigate the effects of short-term treatment with proton pump inhibitors (PPIs) on the gut microbiota of pediatric patients.
- Conditions
- Proton Pump Inhibitors, Human Gastrointestinal Tract, Gastroesophageal Reflux Disease
- Trial name
- PPI (NCT07036627)
- Testing
- study of microbiota
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bari
Neoplasms
Registry Study for Radiation Therapy Outcomes
The purpose of this research study is to collect and analyze information from patients being treated with various forms of radiation therapy.
- Trial name
- NCT01255748
- Testing
- Proton Therapy, Photon Therapy, SRS, Brachytherapy
- Where
- 29 sites in United States
- Volunteers
- 50,000 people
- Sponsor
- Proton Collaborative Group
Pediatric Patients Treated With Radiation Therapy
Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it…
- Trial name
- NCT01696721
- Testing
- No intervention
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Massachusetts General Hospital
Erosive Reflux Disease, Non-erosive Reflux Disease
Predictors of Proton Pump Inhibitor Response in Gastroesophageal Reflux Disease Patients
Proton pump inhibitor (PPI) is widely used in patients with gastroesophageal reflux disease (GERD), however, some patients fail to respond to PPI therapy.
- Conditions
- Erosive Reflux Disease, Non-erosive Reflux Disease, Functional Heartburn
- Trial name
- NCT01797939
- Where
- South Korea
- Volunteers
- 197 people
- Sponsor
- Seoul National University Bundang Hospital
Wilms Tumor
Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation
Participants are being asked to take part in this clinical trial, a type of research study, because the participants have a Wilms Tumor cancer.
- Trial name
- NCT04968990
- Testing
- Proton Beam Radiation (PBRT), DD-4A Chemotherapy Regimen, Complete Surgical Resection
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- St. Jude Children's Research Hospital
Otitis Media With Effusion
A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion
This study is being done to see if reflux of stomach fluid might be a cause of chronic fluid in the ears. Our hypothesis is that treatment with an anti-reflux medication (lansoprazole) will increase the rate of resolution of…
- Trial name
- NCT00546117
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Treatment With Proton Beam Radiation Therapy
Proton Therapy Patient Registry
The purpose of this study is to establish a database (or "registry") of patients treated with proton beam therapy at the University Hospitals (UH) Proton Therapy Center.
- Trial name
- NCT02986048
- Testing
- Proton Beam Therapy
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Case Comprehensive Cancer Center
Brain Tumors, Medulloblastoma
Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline
Radiation constitutes an integral component in the management of primary brain tumors in pediatric and young adults like medulloblastoma, ependymoma, low-grade glioma, pituitary tumors, etc.
- Conditions
- Brain Tumors, Medulloblastoma, Glioma, Ependymoma
- Trial name
- BIO-RIN (NCT06779487)
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Hodgkin Lymphoma
Proton Therapy for Hodgkin Lymphoma
The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.
- Trial name
- HL01 (NCT00850200)
- Testing
- Proton Radiation Plan, Conventional Photon Radiation Plan, Intensity Modulated Radiation Plan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Renal Tumor, Wilms Tumor
Pencil Beam Scanning in Patients With Renal Tumors
This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.
- Trial name
- NCT03810651
- Testing
- Proton beam radiation using pencil beam scanning
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Malignant Brain Glioma
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors
This trial studies how well spectroscopic magnetic resonance imaging (MRI) guided proton therapy works in assessing metabolic change in pediatric patients with brain tumors.
- Trial name
- NCT04908709
- Testing
- Magnetic Resonance Spectroscopic Imaging, Proton Therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Pediatric Cancer Patients
Registry for Analysis of Quality of Life, Normal Organ Toxicity and Survival of Pediatric Patients Treated With Proton Therapy
The study aim of this study is to evaluate the effect of proton therapy on quality of life and long-term normal tissue toxicities of the pediatric cancer patients.
- Trial name
- NCT02644993
- Testing
- Proton therapy
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center