Clinical trials: Tuberculosis, Central Nervous System
Central Nervous System Tuberculosis
A Retrospective Study of Treatment Patterns and Clinical Outcomes in Patients With Central Nervous System Tuberculosis
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis in patients with central nervous system tuberculosis.
- Trial name
- NCT06011915
- Where
- 2 sites in China
- Volunteers
- 638 people
- Sponsor
- Tongji Hospital
Tuberculosis Meningitis
Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis
AlpE is a novel drug combination under development for the treatment of TB, with several positive attributes for TBM, including rapid bactericidal activity.
- Trial name
- NCT07350174
- Testing
- HRZE, HRZE plus Alpe375, HRZE plus AlpE500
- Volunteers
- 64 people
- Sponsor
- BioVersys AG
Tuberculosis, Meningeal
Optimizing Treatment to Improve TBM Outcomes in Children
In this open-labeled, randomized clinical trial, the Investigator will assess the safety and pharmacokinetics (PK) of model-optimized doses of rifampicin (RIF) with or without levofloxacin (LEVO) given to children as part of…
- Trial name
- TBM-KIDS (NCT02958709)
- Testing
- High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB
- Where
- 3 sites in India, Malawi
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Tuberculous Meningitis
Intrathecal Therapy for Adult Tuberculous Meningitis: Impact on Clinical Outcomes
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB). While anti-TB regimens remain the cornerstone of treatment, spinal injection of dexamethasone is considered a potentially effective adjuvant therapy.
- Trial name
- NCT06811792
- Testing
- Intrathecal Therapy
- Volunteers
- 837 people
- Sponsor
- Beijing Chest Hospital
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
Tuberculous Meningitis
Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital
Early diagnosis and appropriate treatment of tuberculous meningitis (TBM) are crucial steps to reduce morbidity and mortality. The WHO recommended to use Xpert MTB/RIF assay to diagnose pulmonary TB, pediatrics TB, extra…
- Trial name
- NCT05781646
- Testing
- Xpert MTB/RIF
- Volunteers
- 62 people
- Sponsor
- Chiang Mai University
Tuberculosis Meningitis
Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone
All patients who were alive at the end of the dexamethasone treatment trial conducted by Oxford University CLinical Research Unit from 2001-2005 (n=340) will be eligible to participate in this long-term follow-up study.
- Trial name
- ES (NCT01317654)
- Testing
- Observation
- Volunteers
- 340 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculosis, Meningitis
Phase II Clinical Study of Contezolid for the Treatment of Tuberculous Meningitis
Contezolid is a novel oxazolidinone antibiotic developed by Shanghai Mengke Pharmaceutical Co., Ltd., which successfully went public in 2021.
- Trial name
- NCT06811025
- Testing
- Contezolid, Linezolid (LZD)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Chest Hospital
Neurological Disorders, Cerebral Malaria
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC
The impact of neurological disorders is enormous worldwide, and it is increased in poor settings, due to lack of diagnosis and treatment facilities as well as delayed management.
- Conditions
- Neurological Disorders, Cerebral Malaria, Bacterial Meningitis, Central Nervous System Tuberculosis
- Trial name
- Nidiag-Neuro (NCT01589289)
- Testing
- Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics)
- Where
- Democratic Republic of the Congo
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Tuberculosis, Polio
Mobile Phone SMS Messages and Automated Calls in Improving Vaccine Coverage Among Children in Pakistan
Routine childhood immunization (RCI) in Pakistan is well below the recommended coverage of 90% with rates as low as 16% in certain regions (Pakistan DHS 2012-3).
- Conditions
- Tuberculosis, Polio, Diphtheria, Pertussis
- Trial name
- NCT03341195
- Testing
- SMS messages and automated calls
- Volunteers
- 3,850 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
HIV/AIDS, Hypertension
Evaluating the Impact of a Community Health Worker Program in Neno, Malawi
This protocol concerns the implementation and evaluation of an intervention designed to realign the existing cadre of Community Health Workers (CHW) in Neno District, Malawi to better support the care needs of the clients they…
- Conditions
- HIV/AIDS, Hypertension, Asthma, Diabetes
- Trial name
- NCT03106727
- Testing
- Household model
- Where
- Malawi
- Volunteers
- 122,395 people, healthy volunteers welcome
- Sponsor
- Partners in Health
Tuberculous Meningitis
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis
The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests.
- Trial name
- TBMBIOMARKER (NCT04308928)
- Where
- South Africa
- Volunteers
- 332 people
- Sponsor
- University of Stellenbosch
Tuberculous Meningitis
Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF
Early and reliable diagnosis of tuberculous meningitis (TBM) still poses a great challenge. One of the underlying difficulties is due to the fact that tubercle bacilli are mainly not present in the cerebrospinal fluid (CSF) but…
- Trial name
- NCT01371916
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Xijing Hospital
Tuberculosis, Diphtheria
Evaluation of an Infant Immunization Encouragement Program in Nigeria
Previous studies have shown that a small incentive can have a large impact on health behaviors like vaccinating children. New Incentives, an international non-governmental organization (NGO), aims to boost demand for immunization…
- Conditions
- Tuberculosis, Diphtheria, Tetanus, Pertussis
- Trial name
- NCT03870061
- Testing
- All Babies Are Equal Initiative (conditional cash transfer program)
- Where
- 3 sites in Nigeria
- Volunteers
- 5,187 people, healthy volunteers welcome
- Sponsor
- GiveWell
Tuberculosis, Tubercular Meningitis
Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity.
- Conditions
- Tuberculosis, Tubercular Meningitis, Arachnoiditis; Tuberculous (Etiology)
- Trial name
- NCT04620772
- Testing
- Cyclophosphamide injection
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculosis, Meningeal
High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study
Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection with high mortality. Current treatment regimens are not based on clinical trials.
- Trial name
- ReDEFINe (NCT02169882)
- Testing
- Rifampicin, Other TB drugs, Adjuvant dexamethasone
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Meningitis, Tuberculous, Pharmacokinetics
Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis infection, and is diagnosed in approximately 5-10% of TB patients.
- Conditions
- Meningitis, Tuberculous, Pharmacokinetics, Pharmacodynamics, Tolerability
- Trial name
- NCT01158755
- Testing
- Moxifloxacin
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Tuberculous Meningitis, Tuberculous Arachnoiditis
Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes
The goal of this Diagnostic accuracy study is To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and To study the correlation of imaging findings in tubercular meningitis and…
- Trial name
- NCT05636254
- Testing
- MRI Brain and spine, Reference standard diagnostic criteria
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculous Meningitis
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC)…
- Trial name
- NCT05383742
- Testing
- Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD)
- Where
- 18 sites in Brazil, India and 10 more
- Volunteers
- 330 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculous Meningitis
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults…
- Trial name
- INTENSE-TBM (NCT04145258)
- Testing
- Aspirin, WHO TBM treatment, Intensified TBM treatment
- Where
- 13 sites in Côte d’Ivoire, Madagascar and 2 more
- Volunteers
- 768 people
- Sponsor
- ANRS, Emerging Infectious Diseases