Clinical trials: Tuberculosis
Tuberculosis
Trial to Investigate the Effect of Schistosoma Mansoni Infection on the Response to Vaccination With MVA85A in BCG-vaccinated African Adolescents
Mycobacterium tuberculosis (M. tb) is a pathogen with worldwide distribution which infects humans causing tuberculosis (TB), a transmissible disease resulting in very high mortality and morbidity; development of an effective…
- Trial name
- TB036 (NCT02178748)
- Testing
- MVA85A
- Where
- Uganda
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Rapid Research in Diagnostics Development for TB Network
To reduce the burden of TB worldwide through more accurate, faster, simpler, and less expensive diagnosis of TB Every year, more than 3 million people with TB remain undiagnosed and 1 million die.
- Trial name
- R2D2TB Network (NCT04923958)
- Testing
- Novel mycobacterial culture techniques, Novel sputum smear microscopy techniques, Sputum-based molecular assays
- Where
- 16 sites in Georgia, India and 6 more
- Volunteers
- 26,436 people
- Sponsor
- University of California, San Francisco
Tuberculosis
Vitamin D Supplementation Enhances Immune Response to Bacille-Calmette-Guerin (BCG) Vaccination in Infants
The purpose of this study is to determine whether a single oral dose of vitamin D given to infants prior to Bacille-Calmette-Guerin (BCG) vaccination will enhance the immune response to BCG vaccination.
- Trial name
- BCG-25-D (NCT01288950)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Mexico
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Tuberculosis Meningitis
Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis
AlpE is a novel drug combination under development for the treatment of TB, with several positive attributes for TBM, including rapid bactericidal activity.
- Trial name
- NCT07350174
- Testing
- HRZE, HRZE plus Alpe375, HRZE plus AlpE500
- Volunteers
- 64 people
- Sponsor
- BioVersys AG
Tuberculosis
Influence of Filarial Infections on Tuberculosis Disease and Tuberculosis Vaccination in Cameroon
Filarial nematodes modulate the host immune response to promote regulatory and T helper type 2 immune responses, which were shown to influence concomitant infections.
- Trial name
- MAP-TB (NCT04547738)
- Testing
- TB treatment according to national guidelines
- Where
- Cameroon
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Tuberculosis, HIV
Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children
Tuberculosis (TB) is a disease affecting the lungs that is caused by a germ spread by coughing. TB infection is currently diagnosed by a skin test that has limited accuracy.
- Trial name
- NCT00604617
- Testing
- Interferon-Gamma Release Assay, RT-23
- Where
- South Africa
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Lung Cancer, Tuberculosis
A Trial on Clinical Efficacy of 1% Versus 2% Lignocaine in Cough Suppression and Pain Relief in Patients Undergoing Flexible Bronchoscopy
Flexible bronchoscopy is a common procedure performed by pulmonary physicians. The use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy varies among physicians, institutions and geographic locations…
- Conditions
- Lung Cancer, Tuberculosis, Sarcoidosis, Interstitial Lung Disease
- Trial name
- NCT01955824
- Testing
- 1% lignocaine, 2% lignocaine
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Close Contacts of Active Tuberculosis
Efficacy of Nyaditum Resae(R) Against Active TB in Georgia
The use of a supplement food like "Nyaditum resae" is a reliable opportunity to stop the progression towards active TB through the most updated knowledge of this disease:the induction of tolerance.
- Trial name
- NCT02897180
- Testing
- Nyaditum resae(R)
- Where
- Georgia
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Fundació Institut Germans Trias i Pujol
Tuberculosis, HIV Coinfection
Closing -TB GAPs - for People Living With HIV: TB Guidance for Adaptable Patient-Centered Service
Tuberculosis (TB) is the world's leading infectious cause of mortality and responsible for 1/3 of deaths in people living with human immunodeficiency virus (PLHIV).
- Conditions
- Tuberculosis, HIV Coinfection, Tuberculosis Infection
- Trial name
- TB_GAPS (NCT05342064)
- Testing
- patient-centered TB preventive therapy, TB preventive therapy adherence support
- Where
- 5 sites in Eswatini, Lesotho and 3 more
- Volunteers
- 6,500 people
- Sponsor
- Baylor College of Medicine
Tuberculosis
Re-evaluating the Duration in Children of TB Treatment
Current tuberculosis (TB) treatment is effective (works well), but it takes a long time to cure TB. This study will evaluate if TB treatment with a higher dose of rifampicin, one of the TB medicines, and shorter TB treatment…
- Trial name
- REDUCE TB (NCT07656012)
- Testing
- Rifampicin, Isoniazid, Pyrazinamide
- Where
- Peru
- Volunteers
- 230 people
- Sponsor
- University of Wisconsin, Madison
Tuberculosis Infection
Evaluation of Immune Cell Markers in Diagnosis of Tuberculosis
Diagnosis of active and latent pulmonary tuberculosis, as well as extrapulmonary tuberculosis, is still a major challenge of TB control in China.
- Trial name
- NCT04148053
- Testing
- TB-antigen responsive T cell markers
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tongji University
Tuberculosis
Population Pharmacokinetics of Anti-tuberculosis Drugs in Children With Tuberculosis
This study is based on the hypothesis that the pharmacokinetics of anti-tuberculosis drugs in TB children are different from adults.
- Trial name
- NCT03625739
- Testing
- anti-tuberculosis drug
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Beijing Children's Hospital
Tuberculosis, Pediatric Infectious Disease
Evaluation of Xpert MTB/RIF Ultra in Stools and Urine to Improve Tuberculosis Diagnosis in Children
Tuberculosis (TB) diagnosis in children is challenging in low and middle-income countries where access to TB culture and X-ray is limited. More than half cases of childhood TB remain undiagnosed every year.
- Trial name
- NCT06239337
- Testing
- Xpert MTB/RIF Ultra in stools and urine
- Where
- 2 sites in Guinea-Bissau, South Sudan
- Volunteers
- 563 people
- Sponsor
- Medecins Sans Frontieres, Spain
Tuberculosis, Pulmonary
Replacement of Vitamin D in Patients With Active Tuberculosis
Tuberculosis is a global public health problem. One third of the world's population is infected with tuberculosis (TB) with almost 2 million deaths per year globally.
- Trial name
- SUCCINCT (NCT01130311)
- Testing
- Cholecalciferol, Saline injection
- Where
- 4 sites in Pakistan
- Volunteers
- 259 people
- Sponsor
- Aga Khan University
Spinal Tuberculosis, Mesenchymal Stem Cell
Effectivity of Mesenchymal Stem Cell on Vertebral Bone Defect Due to Mycobaterium Tuberculosis Infection
This study evaluates the effectiveness of locally implantation of mesenchymal stem cell on vertebral bone defects due to infection of mycobacterium tuberculosis.
- Trial name
- NCT04493918
- Testing
- Mesenchymal Stem cell + Nacl 0.9%, NaCl 0.9%
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Ahmad Jabir Rahyussalim
Tuberculosis, Pleural Effusion
Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis.
- Trial name
- NCT01560078
- Where
- India
- Volunteers
- 360 people
- Sponsor
- All India Institute of Medical Sciences
COVID-19, HIV Seropositivity
Collision of Three Global Pandemics: the Effect of Tuberculosis and HIV on the Epidemiological, Clinical, Virological and Immunological Trajectory of COVID-19 in Botswana and Namibia
COVID-19 has emerged as global pandemic during the past few months, with an unprecedented impact on public health, and society more generally.
- Conditions
- COVID-19, HIV Seropositivity, Tuberculosis, Pulmonary, Tuberculosis Infection
- Trial name
- Core-NB (NCT05268380)
- Testing
- Covid-19, TB and HIV diagnosis
- Where
- Namibia
- Volunteers
- 1,750 people
- Sponsor
- University of Namibia
Latent Tuberculosis
GXT - GeneXpert or Chest-X-ray or Tuberculin Skin Testing for Household Contact Assessment
The objective of the study is to compare outcomes from three different strategies for the management of household (HH) contacts of individuals with newly diagnosed microbiologically confirmed active pulmonary TB.
- Trial name
- NCT04528823
- Testing
- Strategy 2: Symptom screen, Genexpert and TST, Strategy 3:Symptom screen, CXR but NO TST
- Where
- 4 sites in Benin, Brazil
- Volunteers
- 1,589 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tuberculosis
Impact Evaluation of Use of MATCH AI Predictive Modelling for Identification of Hotspots for TB Active Case Finding
The aim of this pragmatic, stepped wedge cluster-randomized trial is to measure the comparative yield (number of incident TB cases diagnosed during active case-finding camps) using a site selection approach based on predictions…
- Trial name
- SPOT-TB (NCT06017843)
- Testing
- Camps site selection for active case finding for TB using MATCH-AI
- Where
- Pakistan
- Volunteers
- 180,000 people, healthy volunteers welcome
- Sponsor
- Centre for Global Public Health Pakistan
Tuberculosis, Multidrug-Resistant, Tuberculosis
Evaluating Newly Approved Drugs in Combination Regimens for Multidrug-Resistant TB With Fluoroquinolone Resistance (endTB-Q)
endTB-Q Clinical Trial is a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of two new, all-oral, shortened regimens for multidrug-resistant tuberculosis…
- Conditions
- Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary Tuberculoses, Mycobacterial Infections
- Trial name
- endTB-Q (NCT03896685)
- Testing
- Bedaquiline 100 MG, Delamanid 50 MG Oral Tablet, Clofazimine 100 MG Oral Capsule
- Where
- 10 sites in India, Kazakhstan and 4 more
- Volunteers
- 323 people
- Sponsor
- Médecins Sans Frontières, France