Clinical trials: Type 2 Diabetes Risk
Coronary Heart Disease, Type 2 Diabetes
Returning Genome and Metabolome Data to FinTerveys 2017 Participants: P5.fi FinTerveys Study
P5.fi study - P4 together with a fifth 'P' and '.fi' for population health Finally Implemented in Finland - studies the value of returning genetic and metabolomic risk information in two diseases (coronary heart disease and type…
- Conditions
- Coronary Heart Disease, Type 2 Diabetes, Deep Vein Thrombosis
- Trial name
- P5 (NCT03650127)
- Where
- Finland
- Volunteers
- 3,449 people, healthy volunteers welcome
- Sponsor
- Markus Perola
Obesity, Prediabetic State
Lifestyle-Related Health Outcomes in Prediabetes and Diabetes
This study looks as how a health education intervention strategy effects health outcomes in overweight and obese adolescents.
- Conditions
- Obesity, Prediabetic State, Type 2 Diabetes
- Trial name
- NCT02535169
- Testing
- Health Education and Coaching Strategy, Dietary consult
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2, Genetics
Phenotyping Genetic Risk for Type 2 Diabetes
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2…
- Trial name
- NCT04024631
- Testing
- 75g glucose beverage (Glucola, Trutol, or similar brand), DXA, whole body
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Body Weight, Obesity
Meta Analysis of the Effect of a Low Glycemic Index Diet and Glycemic Load on Body Weight
A low glycemic index (GI) diet has been associated with improved glycemic control in type 2 diabetes patients and a reduced risk of cardiovascular disease (CVD).
- Conditions
- Body Weight, Obesity, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT02557022
- Testing
- GI and/or GL
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Carbohydrate, Hypoxia
Isolated and Combined Effect of a Low Carbohydrate Diet and Exercise in Hypoxia in Patients With Type 2 Diabetes
The purpose of this study is to determine the effects of isolated chronic exercise in hypoxia and combined exercise in hypoxia with a low carbohydrate diet on hypoxia-induced transcription factor (HIF1-α); glycaemic control and…
- Conditions
- Carbohydrate, Hypoxia, Exercise, Diabetes Mellitus, Type 2
- Trial name
- NCT05094505
- Testing
- Exercise in normoxia, Control diet, Exercise in hypoxia
- Where
- 2 sites in Portugal
- Volunteers
- 42 people
- Sponsor
- Universidade do Porto
Schizophrenia, Schizoaffective Disorder
Schizophrenia, Antipsychotic Treatment and the Risk for Diabetes Mellitus
This preliminary study aims to investigate the mechanism of higher rates of type 2 diabetes mellitus in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Delusional Disorder
- Trial name
- NCT00222807
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Abdominal Obesity
Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, and risk of type 2 diabetes…
- Trial name
- NCT00739180
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Type 2 Diabetes, Diabetic Cardiomyopathy
NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a…
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathy, Heart Failure, Cardiometabolic Diseases
- Trial name
- STRONG-DM (NCT06593327)
- Testing
- Intensive Prevention Strategy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 2 Diabetes, Chronic Disease
Prevention Strategies for Adolescents at Risk of Diabetes
The primary aim of PRE-STARt Phase 1 is to pragmatically evaluate and refine a risk assessment tool to identify those children with chronic disease risk factors (including Type 2 Diabetes).
- Trial name
- PRE-STARt (NCT02545140)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Type 1 Diabetes
Genome-wide Association Study of Different Types of Diabetes and Construction of Genetic Risk Score
To enhance the genetic profile of T1D patients in China and construct a Chinese-specific GRS and evaluated its ability to differentiate between T1D and controls, as well as between T1D and T2D.
- Trial name
- NCT06791330
- Volunteers
- 7,000 people
- Sponsor
- Second Xiangya Hospital of Central South University
Atherosclerosis, Type 2 Diabetes
High-sensitivity C-reactive Protein and United Kingdom Prospective Diabetes Study (UKPDS) Risk Score in Type 2 Diabetes
The UKPDS risk score is recommended to assess global risk for future coronary heart disease (CHD) events in primary prevention. Recently, high-sensitivity C-reactive protein (hsCRP) has emerged as a strong independent risk factor…
- Trial name
- NCT01099865
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Korea University
Childhood Obesity, Type 2 Diabetes
Cardiovascular Risk Factors, Body Composition, Fitness Levels And Quality Of Life In Overweight And Obese 8-17 Year Olds
This project will address the important area of childhood obesity and the risk of cardiovascular disease associated with obesity.
- Conditions
- Childhood Obesity, Type 2 Diabetes, Hypercholesterolemia, Hypertension
- Trial name
- NCT02024399
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Acute Liver Injury
Acute Liver Injury in Patients on Dapagliflozin
To compare, by insulin use at the index date, the incidence of hospitalization for acute liver injury (ALI) among patients with type 2 diabetes mellitus who are new users of dapagliflozin with those who are new users of…
- Trial name
- NCT02695095
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 424,091 people
- Sponsor
- AstraZeneca
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes, Depression
Learning to BREATHE: A Randomized Controlled Trial to Lower Diabetes Risk in Adolescent Girls
Type 2 diabetes is a chronic disease that puts people at risk for major health problems like heart disease. Type 2 diabetes is the most common type of diabetes in adults.
- Conditions
- Type 2 Diabetes, Depression, Obesity
- Trial name
- NCT02218138
- Testing
- Learning 2 BREATHE, Colorado Blues
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Cardiovascular Diseases, Heart Diseases
Enhancing Support for Women at Risk for Heart Disease
To test a practical, theory-based intervention to achieve long-term behavior change for postmenopausal women with Type 2 diabetes at high risk for developing coronary heart disease (CHD).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Coronary Heart Disease Risk Reduction
- Trial name
- NCT00142701
- Testing
- diet, physical activity, stress management
- Sponsor
- Oregon Research Institute
Obesity, Insulin Resistance
Endothelial Function in Hispanic Children/Adolescents at Risk for Type 2 Diabetes
Type 2 diabetes is now more frequent in children/adolescents, especially in those from minority populations, including Hispanic Americans (HA).
- Trial name
- NCT01926925
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Cardiovascular Diseases, Heart Diseases
Diabetes and Cardiovascular Risk In Mexico City (San Antonio Heart Study)
To determine factors beyond obesity which contribute to diabetes and cardiovascular risk in Mexicans and Mexican Americans. To test the hypothesis that at any given level of adiposity Mexican Americans will be more insulin…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent, Diabetes Mellitus
- Trial name
- NCT00005146
- Sponsor
- The University of Texas Health Science Center at San Antonio
Abdominal Obesity, Physical Activity
Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver…
- Trial name
- NCT01323088
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh