Clinical trials: Type Two Diabetes Mellitus
Diabetes Mellitus, Type 2
A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Glargine, Both in Combination With Mealtime Insulin, in People With Type 2 Diabetes Who Use Daily Insulin and Mealtime Insulin (ONWARDS 4)
This study compares insulin icodec (a new insulin taken once a week) to insulin glargine (an insulin taken once daily which is already available on the market) in people with type 2 diabetes.
- Trial name
- ONWARDS 4 (NCT04880850)
- Testing
- Insulin icodec, Insulin glargine, Insulin aspart
- Where
- 116 sites in United States, Belgium and 7 more
- Volunteers
- 582 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Automated Overnight Closed-loop Glucose Control in Young People With Type 1 Diabetes
Children and adolescents with type 1 diabetes need regular insulin injections or continuous insulin delivery with an insulin pump in order to keep blood sugar levels normal.
- Trial name
- APCam05 (NCT00989898)
- Testing
- Automated closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
The Impact of Two Different Insulin Dose Calculation on Postprandial Glycemia After Mixed Meal.
The aim of the study is to compare the impact of two different insulin dose calculation on postprandial glycemia after mixed meal in children with type 1 diabetes mellitus.
- Trial name
- NCT04124302
- Testing
- Insulin Glulisine, Insulin Aspart, Insulin Lispro
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus, Type 1
A Study of Two Versus Three Daily Injections in Children and Adolescents With Newly Diagnosed Type 1 Diabetes
The optimal insulin regimen for children and adolescents with newly diagnosed type 1 diabetes remains unknown. The purpose of this study is to determine whether a split evening injection regimen (insulin injections before…
- Trial name
- NCT00146484
- Testing
- Twice Daily versus Three Times Daily Insulin Injections
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diabetes Mellitus, Diabetes Mellitus, Type 1
Closing the Loop in Children and Adolescents With Type 1 Diabetes in the Home Setting
Type 1 diabetes (T1D) is one of the most common chronic childhood diseases requiring lifelong insulin therapy. Children and adolescents with T1D need regular insulin injections or the continuous insulin delivery using an insulin…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam08 (NCT01778348)
- Testing
- Overnight closed-loop, Real-time CGM alone
- Where
- 3 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Cambridge
Diabetes, Diabetes Mellitus, Type 1
Comparison of Insulin Detemir and Insulin Aspart in 2 Separate Injections Twice Daily to Extemporaneous Mixing Injection Regimen Twice Daily - The Paediatric Mixing Trial
This trial is conducted in Europe. The aim of the trial is to compare two methods of injection in basal-bolus insulin regimen in children with type 1 diabetes with insulin detemir associated with insulin aspart given twice daily…
- Trial name
- MIXING (NCT00542620)
- Testing
- insulin detemir, insulin aspart
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Insulin-based Strategies to Prevent Hypoglycemia During Two Types of Exercise
Regular exercise is associated with many health benefits for individuals with type 1 diabetes. However, immediate and delayed exercise-induced hypoglycemia is frequent and thus the main limiting factor for physical activity…
- Trial name
- RIDE-2 (NCT03845114)
- Testing
- Continous exercise, Interval exercise, Reduction of basal insulin by 40%
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes
Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy
Primary Outcomes: Average decrease in A1c from baseline to end of Study Phase (52 weeks) for subjects in the "722 Group" is greater than that for subjects in the "Control (MDI) Group".
- Trial name
- STAR3 (NCT00417989)
- Testing
- MiniMed Paradigm REAL-Time System
- Where
- 30 sites in United States, Canada
- Volunteers
- 485 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes, Maturity Onset Diabetes of the Young
MODY in Young-onset Diabetes in Different Ethnicities
The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30…
- Conditions
- Diabetes, Maturity Onset Diabetes of the Young, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- MYDIABETES (NCT02082132)
- Where
- United Kingdom
- Volunteers
- 916 people
- Sponsor
- Imperial College London
Type1 Diabetes Mellitus
Comparison of Motor and Sensory Functions of the Hand in Children With Type 1 Diabetes Mellitus and Their Healthy Peers
Type 1 Diabetes Mellitus (T1DM) is a condition where the body cannot produce a hormone called insulin. Although it is commonly seen in children and young people, it can occur at any age.
- Trial name
- NCT06206317
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Erdal AYDIN
Diabetes Mellitus, Non-Insulin-Dependent
Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea
This is a multicenter, randomized, blinded, placebo-controlled study to assess the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes.
- Trial name
- NCT00039026
- Testing
- AC2993
- Where
- 126 sites in United States
- Volunteers
- 377 people
- Sponsor
- AstraZeneca
Diabete Mellitus, Diabetes Mellitus, Type 1
The Efficacy of MDI Treatment With an Optimization Algorithm Adjusting Basal-Bolus Parameters in Children and Adolescents With Type 1 Diabetes at a Diabetes Camp
Our lab at McGill University has developed an optimization algorithm for T1D MDI patients that estimates optimal basal-bolus parameters (basal injections and insulin-to-carbohydrate ratios) using glucose sensor data and insulin…
- Trial name
- NCT03764280
- Testing
- Multiple Daily Injections: Slow acting insulin and Rapid acting insulin
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University
Fasting
Comparison of Two Protocols on the Implementation of a Fasting Day in Type 1 Diabetes
This is a prospective study with a "crossover design", where fasting with a day of complete fasting and a fasting day with the permission intake of calories- and carbohydrate-free foods are compared in a randomized order.
- Trial name
- NCT02667769
- Testing
- Fasting day
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz
Diabetes, Type 1 Diabetes Mellitus
Efficacy of Closed-Loop Strategy With and Without a Learning Component in Children and Adolescents With Type 1 Diabetes at a Diabetes Camp
Our lab has developed an artificial pancreas system called the McGill Artificial Pancreas (MAP) for automating insulin delivery.
- Trial name
- NCT03581968
- Testing
- Artificial Pancreas
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McGill University
Diabetes Mellitus, Type 1, Fasting
Health Education During Ramadan Fasting in Type 1 Diabetes
Adult Muslims are obliged to start fasting during the month of Ramadan. Fasting entails refraining from all food, drink, tablets and injections(vitamins \& fluids) between sunrise and sunset; a period which varies by geographical…
- Trial name
- NCT03501511
- Testing
- IDF modules, Conversational Maps
- Where
- Egypt
- Volunteers
- 53 people
- Sponsor
- Ain Shams University
Diabetes Mellitus Type 1
The Effect of Supplementation With Two Different Doses of Vitamin D on Bone Mineral Density, Vitamin D Levels and Hand Grip Strength in Children With Diabetes Mellitus Type 1
The aim of the study is to assess the effect of 12 month supplementation with two different doses of vitamin D ( 500 vs 1000) on bone mineral density, serum 25 hydroxyvitamin D levels and hand grip strength in preadolescents with…
- Trial name
- NCT01277913
- Testing
- Vitamin D3
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Type 1 Diabetes Mellitus
Carbohydrate-based Strategies to Prevent Exercise-induced Hypoglycemia
To prevent hypoglycemia during prolonged exercise (>30 minutes), additional carbohydrate intake is frequently required. Carbohydrate intake required will vary with insulin regimens, timing and type of exercise as well as starting…
- Trial name
- NCT03214107
- Testing
- Exercise, Snack
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type1diabetes
Two Narrative Medicine Interventions in Type 1 Diabetes
a randomized prospective study aims at comparing the impact of a "living theater" session with a simple "writing workshop " on emotional distress (Problem Areas in Diabetes Questionnaire PAID) and illness perception ( Illness…
- Trial name
- NCT03365349
- Testing
- participating in a session of "living theatre", writing workshop
- Volunteers
- 87 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 1
Hypoglycemia Thresholds in Type 1 Diabetes
The aim of this study is to compare the impact of hypoglycaemia treatment initiated at a blood glucose threshold of 65 mg/dL versus the internationally recommended threshold of 70 mg/dL on 2-hour post-treatment blood glucose…
- Trial name
- NCT07711275
- Testing
- threshold 70 mg/dL, threshold 65 mg/dL
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Marmara University
Diabetes, Diabetes Mellitus, Type 1
Comparison of Two Pen Systems in Patients With Diabetes Treated With Insulin
This trial is conducted in Europe. The aim of this trial is to compare two insulin delivery pens in the everyday life setting of patients with diabetes treated with insulin.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00569998
- Testing
- NovoPen™ 4, NovoPen® 3
- Where
- 23 sites in Austria, Germany and 3 more
- Volunteers
- 208 people
- Sponsor
- Novo Nordisk A/S