Clinical trials: Ulcerative Colitis, Unspecified
Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children With Ulcerative Colitis
Ninety Six patients with mild to moderate ulcerative colitis will be randomized to double blind, placebo controlled study. The safety and efficacy of the intervention will be closely monitored.
- Trial name
- FMT_UC (NCT02291523)
- Testing
- Fecal Microbial Transplant
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Ulcerative Colitis
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study, A3921210 is designed to evaluate the efficacy, safety and pharmacokinetics (PK) of tofacitinib in pediatric participants with moderately to severely active UC.
- Trial name
- NCT04624230
- Testing
- tofacitinib
- Where
- 69 sites in United States, Australia and 14 more
- Volunteers
- 118 people
- Sponsor
- Pfizer
Ulcerative Colitis
Effects of WB-EMS in Ulcerative Colitis Patients
The purpose of this study is to determine the effect of 12 weeks of WB-EMS either applicated passive in a supine resting position or active during slight movements compared with a non-training control group on body composition…
- Trial name
- NCT02144129
- Testing
- active Whole Body Electromyostimulation, Passive WB-EMS, WB-EMS application
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Disease
Precision IFX: Using a Dashboard to Individualize Infliximab Dosage
The introduction of infliximab (IFX) and other monoclonal antibodies (MAbs) targeting tumor necrosis factor (TNF) was a major advancement in the management of inflammatory bowel disease (IBD).
- Trial name
- NCT02624037
- Testing
- Individualized Dosage Precision IFX Dashboard
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Moderately to Severely Active Ulcerative Colitis
A Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
This Phase III, multicenter, double-blind, placebo-controlled, treat-through study will evaluate the efficacy and safety of Afimkibart (RO7790121) compared with placebo in participants with moderately to severely active…
- Trial name
- Ametrine-1 (NCT06589986)
- Testing
- Afimkibart
- Where
- 184 sites in United States, Argentina and 28 more
- Volunteers
- 400 people
- Sponsor
- Hoffmann-La Roche
Inflammatory Bowel Diseases, Ulcerative Colitis
Gut Microbiome in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition for gastrointestinal tract. There have been numerous studies to reveal dysbiosis of fecal/mucosal microbiome composition in IBD patients but actual trend of…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT03589183
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Kyunghee University Medical Center
Ulcerative Colitis
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
The goal of this clinical trial is to determine the clinical effects of two different dietary fibre supplements, acacia gum (AG) and microcrystalline cellulose (MCC), in patients with ulcerative colitis.
- Trial name
- PAIF-UC (NCT06515210)
- Testing
- Acacia Gum, Microcrystalline Cellulose
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Alberta
Crohn's Disease, Ulcerative Colitis
Long-term Scheduled Therapy With Infliximab in Inflammatory Bowel Disease
The primary objective of this study is to evaluate sustained clinical remission (for the definition see below) in patients with inflammatory bowel disease receiving long-term (> 2 years) scheduled treatment with infliximab.
- Trial name
- NCT02057016
- Where
- Italy
- Volunteers
- 258 people
- Sponsor
- Catholic University of the Sacred Heart
IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome)
Specimen and Data Collection for a Novel Biomarker Combination for the Differential Diagnosis of Inflammatory Bowel Disease and Irritable Bowel Syndrome.
This study will evaluate how well the a new stool test can distinguish inflammatory bowel disease (IBD) from non-IBD conditions compared with standard calprotectin testing and colonoscopy findings.
- Conditions
- IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome), Gastrointestinal Symptoms
- Trial name
- COMBI (NCT07471490)
- Where
- 2 sites in United States, Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- DiaSorin Inc.
Ulcerative Colitis, Ulcerative Colitis Chronic
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Ulcerative Colitis
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Ulcerative Colitis
- Trial name
- NCT04148274
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Colitis, Ulcerative
To Evaluate the Efficacy and Safety of FE 999315 in Japanese Subjects With Mild to Moderate Active Ulcerative Colitis
To demonstrate non-inferiority in efficacy of FE 999315 to mesalazine in patients with mild to moderate active ulcerative colitis after 8 weeks of treatment.
- Trial name
- NCT03412682
- Testing
- Budesonide (6 mg), Budesonide (9 mg), Mesalazine (3,600 mg)
- Where
- 72 sites in Japan
- Volunteers
- 274 people
- Sponsor
- Ferring Pharmaceuticals
Ulcerative Colitis
Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis
This study assesses the long-term safety and efficacy of adalimumab in pediatric subjects with ulcerative colitis.
- Trial name
- NCT02632175
- Testing
- Adalimumab
- Where
- 16 sites in United States, Japan and 4 more
- Volunteers
- 59 people
- Sponsor
- AbbVie
Inflammatory Bowel Diseases, Psychosocial Impairment
Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic condition that affects the psychosocial status and physical activities of children and their parents in many ways.
- Trial name
- NCT06270277
- Testing
- Pediatric Quality of Life Inventory (PedsQL), Strengths and Difficulties Questionnaire (SDQ)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Ulcerative Colitis, Pediatric, Inflammatory Bowel Diseases
COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)
The purpose of the study is to compare the clinical effectiveness and safety of newer inflammatory bowel disease (IBD) medications in anti-tumor necrosis factor (TNF) refractory patients with pediatric IBD (PIBD).
- Conditions
- Ulcerative Colitis, Pediatric, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- COMPARE (NCT07198113)
- Where
- 4 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of North Carolina, Chapel Hill
Inflammatory Bowel Diseases, Crohn Disease
The Effect of MedicijnWijs on Adherence to Azathioprine Therapy in Adolescents With IBD
Medication non-adherence is an existing problem in patients with inflammatory bowel diseases (IBD). Adherence rates are especially low in children and adolescents.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- MEDICATION (NCT05321485)
- Testing
- MedicijnWijs
- Where
- 3 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Maxima Medical Center
Ulcerative Colitis
An Efficacy and Safety Study of Ontamalimab as Maintenance Therapy in Participants With Moderate to Severe Ulcerative Colitis
The purpose of this study is to evaluate the efficacy of ontamalimab as maintenance therapy treatment of remission, based on composite score of patient-reported symptoms and centrally read endoscopy, in participants with moderate…
- Trial name
- FIGARO UC 303 (NCT03290781)
- Testing
- Ontamalimab
- Where
- 401 sites in United States, Argentina and 35 more
- Volunteers
- 366 people
- Sponsor
- Shire
Ulcerative Colitis
Combination of Diet and 5ASA ( 5-aminosalicylic Acid) for Ulcerative Colitis
Combination Therapy with Drug and Diet for Induction of Remission in Mild to Moderate Active Pediatric Ulcerative colitis: A Single Blinded, International Randomized Controlled Trial
- Trial name
- INDUCT (NCT03980405)
- Testing
- Group 1- Control Diet, Group 2- UCD Diet
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Prof. Arie Levine
Crohn's Disease, Ulcerative Colitis
Expanded Access to Vedolizumab for Children and Teenagers With Ulcerative Colitis or Crohn's Disease in the USA
The expanded access program (EAP) allows people to gain access to an unlicensed treatment on compassionate grounds. This EAP provides children and teenagers with Ulcerative Colitis (UC) or Crohn's Disease (CD) who completed the…
- Trial name
- NCT06856135
- Testing
- Vedolizumab IV
- Where
- 3 sites in United States
- Sponsor
- Takeda
Ulcerative Colitis
Curcumin in Pediatric Ulcerative Colitis
Background: Curcumin in an active phytochemical substance, used as part of the human diet, that has anti-inflammatory and anti-oxidative properties which were demonstrated in multiple experimental models of colitis including a…
- Trial name
- NCT02277223
- Testing
- Curcumin
- Where
- Israel
- Sponsor
- Schneider Children's Medical Center, Israel
Inflammatory Bowel Diseases, Ulcerative Colitis
Non-Invasive Monitoring Through Bowel Ultrasound in Paediatric Inflammatory Bowel Disease Study
Rates of inflammatory bowel disease (IBD) are increasing rapidly in children and young people, and targets for management are becoming more demanding, with better control of disease to prevent complications, cancers and…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease, Pediatric Crohns Disease
- Trial name
- NIMBUS (NCT05673278)
- Testing
- Bowel Ultrasound Scan
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board