Clinical trials: Unconsciousness
Syncope
The Diagnostic Performance of Tilt Test in Athletes
In the present study the investigators evaluate the sensitivity and specificity of passive tilt test in athletes, as well as their haemodynamic responses and autonomic nervous system activity during head-up tilt.
- Trial name
- NCT02316860
- Testing
- Passive tilt test
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Nurse's Role, Nurse-Patient Relations
Effect of Virtual Reality Simulation on Nursing Students' Knowledge and Skill Performance in Respiratory Physical Examination
Aim To compare the effects of immersive virtual reality (I-VR) and peer-assisted small-group practice on nursing students' knowledge, skill performance, and performance time in respiratory system physical examination.
- Conditions
- Nurse's Role, Nurse-Patient Relations, Exanimation
- Trial name
- NCT06536361
- Testing
- Virtual Reality-Based Learning Tool, Traditional Small Group Training
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gazi University
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Autonomic Nervous System Diseases
PET Scan in Patients With Neurocardiologic Disorders
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system. The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to…
- Trial name
- NCT00001418
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ciprofol
Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages
This study aims to explore dose requirements for loss of consciousness and bispectral index changes during general anesthesia induction with ciprofol in patients of different ages, providing a reference for its rational clinical…
- Trial name
- NCT07148596
- Testing
- It is an observational study without any intervention measures.
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Syncope
Multi-Site Near Infrared Spectroscopy (NIRS) Monitoring of Children During Tilt Table Testing
PURPOSE OF THE STUDY This study will explore the use of multi-site NIRS monitoring during tilt table testing, combining somatic and cerebral saturations data with hemodynamic data to establish the non-invasive assessment of…
- Trial name
- NIRS & Tilt (NCT00659464)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Healthy, Unconscious
External Nitric Oxide Measurement Through SNO Degradation
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis.
- Trial name
- NCT04903535
- Testing
- Alonefire SV003 10W 365nm UV Flashlight
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Persistent Vegetative State
18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness
Clinical examinations are difficult to discriminate between vegetative state and minimally conscious state. the diagnostic and prognostic usefulness of neuroimaging methods has not been established in a clinical setting.
- Trial name
- NCT02999490
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Brain Death
Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury
This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to…
- Trial name
- NCT02742857
- Testing
- BQ-A Peptide Extract, Mesenchymal Stem Cells, Transcranial Laser Therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bioquark Inc.
Vasovagal Syncope, Postural Tachycardia Syndrome
Mechanisms of Vasovagal Syncope
Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness.
- Trial name
- NCT01791816
- Testing
- Phenylephrine, L-Ng-monomethyl Arginine (L-NMMA)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Death
Thyroxine Replacement in Organ Donors
To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration
- Trial name
- NCT00238030
- Testing
- L-thryoxine, iv thryoxine
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Clinical Intuition
CLINICAL INTUITION is an Experience-based, Often Unconscious Assessment of a Patient's Resilience and Tolerance. It is INFLUENCED by Clinical Signs, Behavior, Functioning, and Context. While it MAY PREDICT Patient Dropout, it is Difficult to Objectify.
Patient selection for Phase I oncology trials is formally based on protocol-defined inclusion and exclusion criteria. In practice, however, healthcare professionals also take clinical intuition and professional experience into…
- Trial name
- MINC (NCT07877623)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Syncope, Vasovagal
Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery
Patients's demographics and perioperative factors affect the occurrence of hypotensive bradycardic events in the patients undergoing arthroscopic shoulder surgery in the sitting position under interscalene block.
- Trial name
- NCT01926561
- Testing
- Interscalene brachial plexus block
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Presyncope, Syncope
Oral Water Hydration to Prevent Post-Vaccination Presyncope
This is a randomized controlled open-label trial. During the study, adolescents and young adults scheduled to receive at least one intra-muscular (IM) vaccine will receive either oral water hydration in addition to standard care…
- Trial name
- NCT02353390
- Testing
- Oral Water Hydration
- Where
- 2 sites in United States
- Volunteers
- 1,820 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiac Arrhythmia, Syncope
Comparative Study of the Sternal Patch System With a Conventional Holter Recorder
This study will be a comparison of two externally worn recording systems for documentation of cardiac arrhythmias in symptomatic patients or patients at risk for arrhythmia.
- Trial name
- NCT04241692
- Testing
- CarnationTM Ambulatory Monitoring Sternal ECG Patch System, Conventional 24-Hour 7 Lead Holter Monitor Recorder
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope and Exercise Capacity
Cardioneuroablation (CNA) is a new promising method to treat reflex syncope which is due to vagally-induced functional sinus arrest or atrio-ventricular block (AVB).
- Trial name
- Roman3 (NCT06440291)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Vasovagal Syncope, Postural Tachycardia Syndrome
Hypnosis in Autonomic Function
This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating).
- Conditions
- Vasovagal Syncope, Postural Tachycardia Syndrome, Hypnosis
- Trial name
- NCT00061009
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)