Clinical trials: Unipolar Depression
Major Depressive Disorder
The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology
Gallbladder meridian(GB) acupoints may play an important role in the treatment of major depressive disorder (MDD). Therefore, this study is designed to focus on the traditional Chinese medicine (TCM) theory of " gallbladder…
- Trial name
- NCT05707299
- Testing
- Intradermal acupuncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Non Suicidal Self Injury, Suicidal Ideation
aiTBS for NSSI and Suicide in Adolescent Depression
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression.
- Conditions
- Non Suicidal Self Injury, Suicidal Ideation, Suicide and Self-harm
- Trial name
- NCT06210100
- Testing
- Active iTBS
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Central South University
Depression - Major Depressive Disorder, Catatonia
Optimizing Stimulation Parameters for Electroconvulsive Therapy
The goal of this clinical trial is to improve how electroconvulsive therapy (ECT) stimulation settings are chosen. Researchers will use real-time brain monitoring to measure both seizures and a recently identified brain event…
- Trial name
- PRESTO (NCT07561307)
- Testing
- Electroconvulsive Therapy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Depression - Major Depressive Disorder
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) Combined With Stable Medication in Adolescents With Depression
This randomized, double-blind, sham-controlled pilot study will evaluate the feasibility, acceptability, safety, and preliminary clinical effects of transcranial alternating current stimulation as an adjunctive treatment for…
- Trial name
- NCT07185451
- Testing
- tACS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Depression
EEG-Triggered rTMS and Group Therapy for Adolescents With Depression and Self-Harm
This randomized controlled trial aims to evaluate the efficacy of real-time EEG-triggered repetitive transcranial magnetic stimulation (rTMS) combined with group therapy versus rTMS alone in adolescents (aged 12-18 years)…
- Trial name
- NCT07047534
- Testing
- Real-time EEG-triggered Repetitive Transcranial Magnetic Stimulation (rTMS), Group Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Hospital of Hebei Medical University
Mood Disorders, Bipolar Disorder
Technology Enhanced Family Treatment
The investigators propose to enhance the scalability of family-focused therapy (FFT), a 12-session evidence-based therapy for youth at high risk for mood disorders, through augmentation with a novel mobile phone application…
- Conditions
- Mood Disorders, Bipolar Disorder, Major Depression
- Trial name
- NCT03913013
- Testing
- Family-Focused Treatment with MCC App
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Feasibility of Internet-delivered CBT for Adolescents With Depression
Prior to a properly powered randomized controlled study, evaluating efficacy and cost-effectiveness of ICBT, we will conduct a pilot study to investigate if the trial design is feasible, if therapist-guided and self-guided…
- Trial name
- NCT04117789
- Testing
- Therapist-guided internet-delivered cognitive behavior therapy for depression in adolescents, Self-guided internet-delivered cognitive behavior therapy for depression in adolescents, Treatment as usual
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Major Depressive Disorder
Precision Medicine for the Prediction of Treatment (PROMPT) Response (PROMPT)
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the first-line treatment choice; however, only about one third of patients respond to…
- Trial name
- PROMPT (NCT05537558)
- Testing
- Antidepressant
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Depressive Disorder, Major
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)
Investigation of the efficacy and safety of a new potential treatment of Major depressive disorder (MDD) in paediatric participants (age 7 to 11 years).
- Trial name
- NCT02709655
- Testing
- Vortioxetine 10 mg/day, Vortioxetine 20 mg/day, Fluoxetine 20mg/day
- Where
- 98 sites in United States, Bulgaria and 17 more
- Volunteers
- 683 people
- Sponsor
- H. Lundbeck A/S
Depression / Major Depressive Disorder, Anxiety
Activating Voice Journaling for Mental Health With Voice Biomarkers
This retrospective observational study evaluated the relationship between voice characteristics and self-reported mental health symptoms using longitudinal data collected through the Kintsugi Voice Journaling app.
- Trial name
- NCT07789808
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Kintsugi Mindful Wellness, Inc.
Major Depressive Disorder
Neural Components Underlying the Treatment of Adolescent Depression
The goal of the study is to examine how cognitive behavioral therapy (CBT), a common treatment for adolescent depression, affects brain functioning.
- Trial name
- NCT01717508
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder
Mental Health Telemetry for Self-Management in Major Depression
Mood journaling is a cornerstone of self-management in major depressive disorder (MDD). Research over the last decade has shown that electronic mood journals are superior to paper ones.
- Trial name
- MHTV (NCT01999010)
- Testing
- MHT
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Sunnybrook Health Sciences Centre
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
To evaluate the safety and efficacy of daily, active Neurostar® TMS (when compared with sham treatment) in adolescents meeting criteria for Major Depressive Disorder (MDD).
- Trial name
- NCT02586688
- Testing
- Active NeuroStar® Transcranial Magnetic Stimulation (TMS)
- Where
- 13 sites in United States
- Volunteers
- 112 people
- Sponsor
- Neuronetics
Depressive Disorder, Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR) In The Treatment Of Child and Adolescent Outpatients With Major Depressive Disorder
The primary purpose of this study is to evaluate the long-term safety and tolerability of Desvenlafaxine Succinate Sustained-Release (DVS SR) in child and adolescent outpatients with major depressive disorder.
- Trial name
- NCT00669110
- Testing
- Desvenlafaxine Succinate Sustained-Release Tablets (DVS SR)
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Unipolar
Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness
This study examines the efficacy of bright light therapy as a treatment for adolescents diagnosed with unipolar non-seasonal depression who exhibit an evening chronotype.
- Trial name
- NCT06973759
- Testing
- Bright light therapy, Dim red light
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Depression, Unipolar
PF-04995274 and Emotional Processing in Un-medicated Depression
This study will test whether seven days administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on cognition, emotional processing and neural activity in unmedicated depressed…
- Trial name
- RESTAND (NCT03516604)
- Testing
- PF-04995274, Citalopram
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Oxford
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Parents of Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05335564
- Testing
- General information about depression
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depression, Depressive Episodes
Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting AdolescenT Health
The purpose of this randomized multiple-site clinical study is to determine whether a revised CATCH-IT (Internet-based depression prevention program) is more effective than a general health education Internet intervention (Health…
- Trial name
- CATCH-IT (NCT01893749)
- Testing
- CATCH-IT
- Where
- 7 sites in United States
- Volunteers
- 1,142 people, healthy volunteers welcome
- Sponsor
- Benjamin Van Voorhees, MD, MPH
Depression, Depressive Disorder
Web-based Self-help Intervention for Adolescents With Acute or Remitted Major Depressive Disorder
This study aims to evaluate the feasibility and effectiveness of a web-based self-help intervention in adolescents with acute or remitted major depressive disorder.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms, Depressive Disorder, Major
- Trial name
- NCT04994470
- Testing
- Two-week web-based self-help intervention based on principles of positive psychology, Two-week web-based text messages containing fun facts
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich