Clinical trials: Unipolar Major Depression
Depression, Unipolar
Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness
This study examines the efficacy of bright light therapy as a treatment for adolescents diagnosed with unipolar non-seasonal depression who exhibit an evening chronotype.
- Trial name
- NCT06973759
- Testing
- Bright light therapy, Dim red light
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Depression, Unipolar, Eveningness
Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype
The goal of this prospective randomised controlled trial is to examine the effects of cognitive behavioural therapy and bright light therapy in youths with unipolar depression and evening chronotype.
- Trial name
- DELAY (NCT06092411)
- Testing
- Cognitive Behavioural Therapy for Depression, Bright Light Therapy
- Where
- Hong Kong
- Volunteers
- 162 people
- Sponsor
- The University of Hong Kong
Electroconvulsive Therapy, Major Depressive Disorder
Impact of Covid-19 Pandemic on Patients Receiving Continuation or Maintenance Electroconvulsive Therapy
Electroconvulsive therapy is a safe and effective therapeutic strategy in patients with treatment resistant depression. As relapse after successful ECT is significant even with adequate pharmacological strategies, continuation…
- Conditions
- Electroconvulsive Therapy, Major Depressive Disorder, Covid-19
- Trial name
- COVID-M-ECT (NCT05633368)
- Testing
- Questionnaires
- Where
- 2 sites in Belgium
- Volunteers
- 47 people
- Sponsor
- University Hospital, Ghent
Depressive Disorder, Depression, Unipolar
Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Symptoms After Hospital Discharge (Mind-WIN Pilot Study) (Mind-WIN Pilot)
Mind-WIN is a digitally supported (app- and web-based) aftercare program for young people between the ages of 12 and 17, which was developed for adolescent patients with depressive symptoms and is intended to be used after…
- Trial name
- MindWinPilot (NCT07007247)
- Testing
- Mind-WIN self-help only, Mind-WIN blended care
- Where
- 3 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Unipolar Depression, Dysthymia
A Clinical Trial of IPT-A to Prevent Suicide in Depressed Adolescents With Suicidal Behavior
The investigators are adapting Interpersonal Psychotherapy (IPT-A) for adolescents who are referred to emergency services either for a suicide attempt or for being evaluated as high risk for suicidal behavior.
- Trial name
- IPT-A-CSP (NCT01447602)
- Testing
- IPT-A
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder, Major Depression
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
The purpose of the study is to find out what parts of the brain have increased or decreased activity and connectivity in individuals who have bipolar disorder, major depression, or no history of mood disorder.
- Trial name
- NCT01811147
- Testing
- Selective Serotonin Reuptake Inhibitor (SSRI)
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Arthrogryposis, Craniofacial Abnormalities
Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions
Freeman-Sheldon syndrome (FSS) is a rare human neuromusculoskeletal disorder present before birth, involving primarily limb and craniofacial deformities.
- Conditions
- Arthrogryposis, Craniofacial Abnormalities, Posttraumatic Stress Disorder, Depressive Disorder
- Trial name
- FSS-QLS (NCT01307475)
- Testing
- PTSD Checklist-Specific, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale
- Where
- 2 sites in United States, Guatemala
- Volunteers
- 6 people
- Sponsor
- Freeman-Sheldon Research Group, Inc.
Major Depressive Disorder, Bipolar Depression
aiTBS for Relieving NSSI in Depressive Patients
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression. However, its role in alleviating self injuries without suicidal ideation remained uncertain.
- Trial name
- NCT05384405
- Testing
- Active iTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Central South University
Depression, Unipolar
Validity and Reliability of Vietnamese Version of 17items-Hamilton Depression Rating Scale
this reseach examines the reliability and validity of 17 items- Hamilton Depression rating scale in Vietnamese population, which has been commonly used in clinical depression practice and study.
- Trial name
- NCT04205747
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Depression
Clinical Trial of Memantine for Major Depression
The purpose of this study is to determine the safety and effectiveness of the drug memantine for treating major depression. Major depression is a serious public health concern that contributes to significant morbidity and…
- Trial name
- NCT00040261
- Testing
- Memantine HCL
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Unipolar, Treatment Resistant Depression
PF-04995274 and Emotional Processing in Treatment Resistant Depression
This study will test whether seven days adjunctive administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on emotional processing and non-emotional cognition in medicated…
- Trial name
- RESTART (NCT03515733)
- Testing
- PF-04995274
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Oxford
Unipolar Depression
Ketamine Trial for the Treatment of Depression
This study is a Randomized Controlled Trial, investigating the safety and efficacy of administration of ketamine as a potential treatment for depression.
- Trial name
- NCT02401139
- Testing
- Ketamine
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- The University of New South Wales
Depression, Unipolar
Treating Major Depression With Yoga: A Prospective, Randomized Controlled Pilot Trial
This was a randomized controlled pilot trial to evaluate clinical efficacy and feasibility of hatha yoga as a mono-therapy for major depression.
- Trial name
- NCT01210651
- Testing
- Hatha Yoga Practice Group, Attention Control Education Group
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Unipolar Depression
Depression Outcomes Study of Exercise
This pilot study may yield important research findings on how to adapt exercise treatment for depression among adolescents. Potential public health benefits from this study include a reduction of adolescent depression and…
- Trial name
- DOSE (NCT00964054)
- Testing
- Public Health Dose of Exercise (PHD), Low Dose Exercise (LD)
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Anxiety Disorders, Depression
A Waitlist-Controlled Trial of the Unified Protocol for the Treatment of Emotional Disorders in Adolescents
This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders.
- Trial name
- NCT00628888
- Testing
- Unified Protocol for Adolescents (UP-A)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Miami
Depression
Riluzole to Treat Major Depression
This study will examine the safety and effectiveness of the drug riluzole (Rilutek® (Registered Trademark)) for short-term treatment of depression symptoms, such as depressed mood, psychomotor retardation, and excessive sleeping.
- Trial name
- NCT00026052
- Testing
- riluzole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Depression
Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder.
- Trial name
- NCT00338806
- Testing
- Interpersonal psychotherapy for prevention with adolescents, Educational clinical monitoring
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Depression, Unipolar
PF-04995274 and Emotional Processing in Un-medicated Depression
This study will test whether seven days administration of a serotonin receptor subtype 4 (5HT4) agonist called PF-04995274 has positive effects on cognition, emotional processing and neural activity in unmedicated depressed…
- Trial name
- RESTAND (NCT03516604)
- Testing
- PF-04995274, Citalopram
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Oxford