Clinical trials: Upper Extremity
Cerebral Palsy
Evaluation the Feasibility and Effects of Kinect-based Computer Games as UE Training Tool in Cerebral Palsy Children
The purpose of this study is to design and evaluation the feasibility, effects of Kinect-based Computer Games as Upper Extremity Training Tool in Children with Cerebral Palsy.
- Trial name
- NCT02364245
- Testing
- Kinect, Traditional OT(30 Mins), Traditional OT(60 Mins)
- Where
- Taiwan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Metastatic Breast Cancer
A Study of Trastuzumab Emtansine (Trastuzumab-MCC-DM1) Administered Intravenously to Patients With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
This was a multi-institutional, open-label, single-arm, Phase II study of trastuzumab emtansine (T-DM1) administered by intravenous (IV) infusion to patients with human epidermal growth factor receptor 2 (HER2)-positive…
- Trial name
- NCT00509769
- Testing
- Trastuzumab emtansine [Kadcyla]
- Where
- 40 sites in United States
- Volunteers
- 112 people
- Sponsor
- Genentech, Inc.
HIV Infections
A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past
To compare the efficacy, safety and tolerance, and other clinical and immunologic effects of zidovudine (AZT) plus zalcitabine (dideoxycytidine; ddC), AZT plus didanosine (ddI), and AZT alternating monthly with ddI as measured by…
- Trial name
- NCT00001029
- Testing
- Zidovudine, Zalcitabine, Didanosine
- Where
- 37 sites in United States, Puerto Rico and 1 more
- Volunteers
- 654 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Spastic Cerebral Palsy
INcobotulinumtoxina in ChIldren Upper and Lower Limb sPasticITy (INCIPIT)
Prospective, open-label, non-randomized, single-arm, dose titration, phase II study. The study will consist of three injection cycles. In each, an injection visit is followed by an observation period of 12 to 20 weeks.
- Trial name
- INCIPIT (NCT05340439)
- Testing
- IncobotulinumtoxinA 100 UNT [Xeomin]
- Volunteers
- 30 people
- Sponsor
- Universita di Verona
Cerebral Palsy
Scapular Alignment and Upper Limb Function in Children With Cerebral Palsy
Purpose: To determine the effect of scapular alignment on upper limb function in hemiparetic children and to find relation between scapular alignment of the affected, less affected limb and the upper limb function in children…
- Trial name
- Hemiparesis (NCT04644588)
- Testing
- Children with hemiparetic cerebral palsy being assessed for scapular alignment and upper limb function.
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Acute Myeloid Leukemia, Maintenance Treatment
The Maintenance Treatment of "ITIVA" in AML Patients
We apply for this clinical study to evaluate the efficacy of "combined recombinant human interference'- α- 1b, interleukin-2, and thalidomide" regimen in obtaining MRD positive AML patients in CR,as well as the efficacy of the…
- Conditions
- Acute Myeloid Leukemia, Maintenance Treatment, Minor Residue Disease, Interferon-α-1b
- Trial name
- NCT06256627
- Testing
- recombinant human interference'- α- 1b, interleukin-2, thalidomide, Venentoclax and Azacitidine
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Henan Cancer Hospital
AML, IDH1 Mutation
Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML
Venetoclax can bind to the BCL-2 protein, thereby initiating the apoptosis program and exerting anti-AML effects. The induction regimen combining venetoclax with hypomethylating agents (HMA) significantly improves the remission…
- Conditions
- AML, IDH1 Mutation, Treatment
- Trial name
- IDH1-AML-2024 (NCT06611839)
- Testing
- Ivosidenib, Venetoclax, Azacitidine
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Neuroblastoma
Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study.
The survival rate of recurrent and refractory neuroblastoma is low and the prognosis is poor. Apatinib mesylate is a highly selective small-molecule vasoendothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor.
- Trial name
- NCT05027386
- Testing
- Apatinib, Irinotecan, Temozolomide
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Sun Yat-sen University
Systemic Lupus Erythematosus
Obe-cel in Adolescent [Applicable in UK Only] and Adult Severe, Refractory Systemic Lupus Erythematosus
This is a Phase 1 study of obecabtagene autoleucel (obe-cel), autologous T cells engineered with a chimeric antigen receptor (CAR) targeting CD19, to establish the tolerability, safety, preliminary efficacy, and pharmacokinetics…
- Trial name
- CARLYSLE (NCT06333483)
- Testing
- Obecabtagene autoleucel (obe-cel)
- Where
- 6 sites in Spain, United Kingdom
- Volunteers
- 16 people
- Sponsor
- Autolus Limited
Surgical Site Infection, Surgical Wound Infection
ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions
ROSSINI 2 is a phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor), multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of several in-theatre…
- Conditions
- Surgical Site Infection, Surgical Wound Infection, Surgery--Complications, Surgery
- Trial name
- ROSSINI 2 (NCT03838575)
- Testing
- 2% alcoholic chlorhexidine skin prep (SKIN PREP), Iodophor Antimicrobial Incise Drapes (DRAPE), Gentamicin-impregnated implants/ sponges (SPONGE)
- Where
- 2 sites in United Kingdom
- Volunteers
- 6,610 people
- Sponsor
- University of Birmingham
Syphilis
The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care
The goal of this clinical trial is to learn if a finger-prick blood test for rapid diagnosis of syphilis infection can be implemented in a low-barrier prenatal clinic for people at risk of syphilis in pregnancy.
- Trial name
- PRESSING (NCT06829602)
- Testing
- Rapid Syphilis/HIV point-of-care test
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McMaster University
Radius Fracture Distal
Minimal Invasive Volar Plating Versus Cast Immobilization for Treatment of Stable Non-displaced Distal Radial Fractures.
Nondisplaced distal radial fractures are nowadays treated by plaster cast immobilization. In this study, the investigators challenge this classical standard treatment with a surgical solution: minimal invasive volar plating with…
- Trial name
- NCT05015556
- Testing
- Minimal invasive volar plating
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Goorens Chul Ki
Quality of Upper Limb Function, Participation Activities
Relationship Between Upper Limb Function and Participation in Hemiplegic cp
The study will be conducted to Assess quality of upper limb function in children with hemiplegic CP. Assess participation activities of children with hemiplegic CP.
- Conditions
- Quality of Upper Limb Function, Participation Activities, Hemiplegic CP
- Trial name
- NCT07497100
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Primary Hyperoxaluria Type 1, Primary Hyperoxaluria
A Study to Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1
The purpose of this study is to evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics (PD) of lumasiran in patients with Advanced Primary Hyperoxaluria Type 1 (PH1).
- Trial name
- ILLUMINATE-C (NCT04152200)
- Testing
- Lumasiran
- Where
- 14 sites in United States, Australia and 9 more
- Volunteers
- 21 people
- Sponsor
- Alnylam Pharmaceuticals
Deep Vein Thrombosis
Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis
This is a prospective, multi-center single arm registry to assess the use of the OmniWave Endovascular System in subjects presenting with either lower or upper extremity acute (symptoms have been present for greater than or equal…
- Trial name
- SONIC I (NCT00640731)
- Testing
- OmniWave Endovascular System
- Volunteers
- 50 people
- Sponsor
- OmniSonics Medical Technologies, Inc.
Trauma
Psycho-education Program BLAME-LESS and It's Effect on Traumarelated Shame and Guilt
The primary objective of the BLAME-LESS study is to examine the effectiveness of an online psychoeducation program in reducing trauma-related feelings of shame and guilt in adolescents who experienced sexual or physical abuse .
- Trial name
- BLAME-LESS (NCT05987735)
- Testing
- BLAME-LESS
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Karakter Kinder- en Jeugdpsychiatrie
Humeral Fractures, Fractures, Closed
Pain Management in Children Undergoing Supracondylar Humerus Fracture Repair
The purpose of this study is to determine if US-guided supraclavicular anesthetic blocks reduce postoperative pain, use of rescue medication, and improve functional outcomes in children who underwent surgery for supracondylar…
- Trial name
- NCT01812863
- Testing
- Supraclavicular nerve block
- Where
- United States
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Rehabilitation, Physical Therapy
Leap Motion Based Exercises in Upper Extremity Rehabilitation of The Children
Juvenile Idiopathic Arthritis (JIA), Cerebral Palsy (CP), and Obstetric Brachial Plexus Injury (OBPI) are the most common disorders that cause upper extremity impairments in children.
- Trial name
- LMBE (NCT03078998)
- Testing
- Leap Motion Based Exercises
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Leukemia, Graft-versus-host-disease
A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT.
A single-arm trial using Tocilizumab for acute GVHD prophylaxis after haploidentical HSCT.
- Trial name
- NCT04688021
- Testing
- Cytarabine, Busulfan, Cyclophosphamide
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Yi Luo
Cerebral Palsy Infantile, Chronic Pain
Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children
The goal of this clinical trial is to test the effectiveness of a trunk and upper extremities exercise program. The main questions it aims to answer are: Whether the program decreases compensation patterns in unilateral cerebral…
- Conditions
- Cerebral Palsy Infantile, Chronic Pain, Upper Extremity Dysfunction
- Trial name
- TUPEX (NCT06069765)
- Testing
- TUPEX
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundacio Aspace Catalunya
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