Clinical trials: Upper Extremity
Rett Syndrome
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
This study will evaluate the efficacy and safety profiles of the investigational gene therapy, NGN-401, in females with typical Rett syndrome.
- Trial name
- NCT05898620
- Testing
- NGN-401
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 33 people
- Sponsor
- Neurogene Inc.
Leukemia, Stem Cell Transplant
Post-transplant PT/FLU+CY Promotes Unrelated Cord Blood Engraftment in Haplo-cord Setting in Childhood Leukemia
To determine if the novel regimen of PT/FLU+CY promotes cord blood engraftment in children's leukemia HSCT cohort
- Conditions
- Leukemia, Stem Cell Transplant, Cord Blood
- Trial name
- NCT06155188
- Testing
- applying of FLU+CY post-HSCT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Cerebral Palsy (CP)
The Effects of Intensive Physiotherapy in Children With Spastic Cerebral Palsy
The aim of this study is to investigate the effects of a 2-week Neurodevelopmental Treatment (NDT)-based intensive physiotherapy program with active participation on postural control and selective motor control of the lower and…
- Trial name
- NCT07350096
- Testing
- Neurodevelopmental Therapy, Conventional Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Medipol University
Humeral Fractures
ORIF Versus CRIF of Completely Displaced and Rotated Lateral Condylar Fractures of the Humerus in Children
Open reduction and internal fixation has been widely used in treating completely displaced and rotated lateral condylar fracture in children and it usually produces good results.
- Trial name
- NCT04640727
- Testing
- open reduction, closed reduction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Epstein-Barr Virus-associated Lymphoproliferative Diseases, Chronic Active Epstein-Barr Virus Infection
Unrelated Cord Blood Transplantation for EBV-associated Lymphoproliferative Disorders
This clinical trial is designed as a single-arm, two-center, open-label, prospective study. All participants are enrolled in the standard-dose unrelated umbilical cord blood transplantation group to evaluate the efficacy and…
- Conditions
- Epstein-Barr Virus-associated Lymphoproliferative Diseases, Chronic Active Epstein-Barr Virus Infection, EBV Associated Lymphoma, Umbilical Cord Blood Transplant
- Trial name
- NCT07381738
- Testing
- Umbilical cord blood transplantation as treatment of Epstein-Barr virus-associated lymphoproliferative diseases
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Osteoarthritis Elbow Left, Osteoarthritis Elbow Right
Elbow Arthroscopy Data Analysis
The purpose of this study is to evaluate preoperative objective measurements and operative objective measurements to determine if there is any effect to postoperative outcomes.
- Conditions
- Osteoarthritis Elbow Left, Osteoarthritis Elbow Right, Lateral Epicondylitis, Left Elbow, Lateral Epicondylitis, Right Elbow
- Trial name
- EA (NCT03656185)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Orthopaedic Research & Innovation Foundation
Distal Forearm Fracture, Distal Radius Fracture
Is Casting of Displaced Pediatric Distal Forearm Fractures Non-inferior to Reduction in General Anesthesia?
Treatment of displaced distal forearm fractures (DFF) in children have traditionally been closed reduction and pin fixation, although they might heal and remodel without manipulation, with no functional impairment.
- Trial name
- CASTING (NCT05736068)
- Testing
- Non-surgical treatment, Surgical treatment
- Where
- 4 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Familial Mediterranean Fever (FMF )
A Study to Evaluate Efficacy and Safety of Anakinra in Chinese Patients With Colchicine-resistent FMF
The purpose of this study is to evaluate the efficacy and safety of anakinra in Chinese patients with colchicine-resistand Familial Mediterranian Fever (FMF).
- Trial name
- NCT06666335
- Testing
- Anakinra
- Sponsor
- Swedish Orphan Biovitrum
Pneumococcal Disease
Safety and Immunogenicity of V114 in Healthy Infants in South Korea (V114-036)
The primary purpose of this phase 3, single-arm, open-label study is to evaluate the safety and immunogenicity of a 4-dose regimen of V114 administered to healthy infants in South Korea.
- Trial name
- PNEU-PED-KOR (NCT04633226)
- Testing
- V114
- Where
- 19 sites in South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Wrist Injuries, Carpal Bone Fracture
The Canadian Prospective Pragmatic Perilunate Outcomes Trial
This is a unique three-fold prospective and retrospective study. With this approach, all previous and current PLIs presented at participating study sites will have the potential to be included in the study.
- Conditions
- Wrist Injuries, Carpal Bone Fracture, Dislocation of Wrist, Trauma
- Trial name
- C3PO (NCT04370626)
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- University of Calgary
Primary Immune Deficiency
Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency
The purpose of this study is to evaluate the pharmacokinetics and safety of Immune Globulin Intravenous (Human) GC5107 in pediatric subjects with Primary Humoral Immunodeficiency (PHID).
- Trial name
- NCT04565015
- Testing
- GC5107
- Where
- 8 sites in United States, Bosnia and Herzegovina and 1 more
- Volunteers
- 24 people
- Sponsor
- GC Biopharma Corp
Steroid Refractory Acute Graft Versus Host Disease
Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease
This is a single-arm, open-label, multicenter study of the efficacy of UVADEX® (methoxsalen) Sterile Solution in conjunction with THERAKOS® CELLEX® Photopheresis Systems (ECP) in pediatric participants with steroid-refractory…
- Trial name
- NCT02524847
- Testing
- Methoxsalen, Extracorporeal Photopheresis (ECP)
- Where
- 32 sites in United States, Austria and 6 more
- Volunteers
- 29 people
- Sponsor
- Therakos, Inc., a Mallinckrodt Company
Social Communication Disorder, Autism
Feasibility Trial of Parent-delivered Social Communication Program
The Hanen Centre®'s More Than Words® (MTW) program is a globally used, parent coaching intervention delivered by speech-language pathologists (SLPs) to parents of children with social communication challenges, including those who…
- Trial name
- NCT06847347
- Testing
- More Than Words®
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Western University, Canada
Microbiota, Gut Microbiome
Flourish: Exploring the Early Infant Gut Microbiome
The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months…
- Conditions
- Microbiota, Gut Microbiome, Eczema, Microbiome
- Trial name
- NCT07333482
- Testing
- Tailored Recommendations, Consult Call, Educational Email Series
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
EBV Associated Lymphoid Neoplasms
KSD-101 in Patients With EBV-associated Hematological Malignancies
Epstein-Barr virus (EBV) is a double-stranded DNA virus belonging to the Gammaherpesvirinae subfamily of Herpesviridae. It primarily infects B cells and pharyngeal epithelial cells, and can also infect NK cells and T cells.
- Trial name
- NCT07525024
- Testing
- Autologous dendritic cell vaccine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Severe Combined Immunodeficiency Due to ADA Deficiency
A Clinical Study to Enable Process Validation of Commercial Grade OTL-101
The purpose of the current study is to treat at least 3 ADA-SCID patients with OTL-101 prepared by the commercial manufacturing process.
- Trial name
- NCT04140539
- Testing
- OTL-101
- Where
- United States
- Sponsor
- University of California, Los Angeles
Acute Myeloid Leukemia, Relapse Leukemia
Phase I/II Study of Enhanced CD33 CAR T Cells in Subjects With Relapsed or Refractory Acute Myeloid Leukemia
This is a open-label, nonramdominzed, single-arm, Phase I/II Study to evaluate safety and tolerability of functionally enhanced CD33 CAR-T cells in subjects with relapsed or refractory acute myeloid leukemia.
- Conditions
- Acute Myeloid Leukemia, Relapse Leukemia, Refractory Acute Myeloid Leukemia
- Trial name
- NCT04835519
- Testing
- chimeric antigen receptor T cell
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Beijing Boren Hospital
Rhinitis, Seasonal, Allergic
StahistRx Phase 2, Five-arm, Parallel Group, Active vs Active, Double-blind Study
This active vs active comparative trial will evaluate the safety and efficacy of incremental doses of atropine in combination with pseudoephedrine 120 mg/chlorpheniramine 8 mg in adult patients with a history of seasonal allergic…
- Trial name
- NCT02082054
- Testing
- PSE 120 mg, CM 8 mg, Atr 0.36 mg, PSE 120 mg, CM 8 mg, Atr 0.24 mg, PSE 120 mg, CM 8 mg, Atr 0.12 mg
- Where
- 4 sites in United States
- Volunteers
- 125 people
- Sponsor
- Magna Pharmaceuticals, Inc.
Hepatocellular Carcinoma
SHR-1210 Combined With Apatinib Mesylate in the Perioperative Treatment of Hepatocellular Carcinoma
This is a Phase II , Open-label , Investigator-initiated Trail of SHR-1210 (an Anti-PD-1 Inhibitor) in Combination With Apatinib in Patients With Hepatocellular Carcinoma(HCC).This study aims to evaluate the safety and efficacy…
- Trial name
- HCC-009 (NCT04297202)
- Testing
- Apatinib Combined With SHR-1210 Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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