Clinical trials: Upper Limb Function
Spinal Muscular Atrophy
Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)
To evaluate the safety, tolerability and efficacy of intravenous administration of OAV101 (AVXS-101) in patients with spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene weighing ≥…
- Trial name
- SMART (NCT04851873)
- Testing
- OAV101
- Where
- 13 sites in United States, Australia and 7 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Muscular Dystrophies, Muscular Dystrophy, Duchenne
A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy
HOPE-2 is a double-blind clinical trial evaluating the safety and efficacy of a cell therapy called CAP-1002 in study participants with Duchenne Muscular Dystrophy (DMD).
- Conditions
- Muscular Dystrophies, Muscular Dystrophy, Duchenne, Muscular Disorders, Atrophic, Muscular Diseases
- Trial name
- HOPE-2 (NCT03406780)
- Testing
- CAP-1002
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- Capricor Inc.
Spastic Hemiplegic Cerebral Palsy
The Effect of Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, and Quality of Life in Hemiplegic Cerebral Palsy
The purpose of this study is to investigate brain reorganization, functional motor development, level of daily living activity and quality of life of upper extremity mirror therapy in children with spastic hemiplegic cerebral…
- Trial name
- NCT03612128
- Testing
- control group, intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Down Syndrome
Effects of Task-oriented Training on Visual-motor Integration and Upper Limb Function in Children With Down Syndrome
The condition known as Down Syndrome (DS) is caused by trisomy 21, or the presence of an extra copy of chromosome 21. DS is the most common survivable autosomal aneuploidy and one of the genetically complicated problem compatible…
- Trial name
- NCT06943261
- Testing
- task oriented training, conventional therapy
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Spastic Hemiplegic Cerebral Palsy
Modified Constraint-Induced Movement Therapy in Children With Hemiparetic Cerebral Palsy
Cerebral palsy (CP) is defined as a non-progressive lesion of the developing foetal or infant brain and causes variety of motor, sensory and cognitive impairments.
- Trial name
- NCT04064788
- Testing
- Consecutive Modified Constraint-Induced Movement Therapy, Traditional physiotherapy, Intermittent Modified Constraint-Induced Movement Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Abant Izzet Baysal University
Perinatal Brain Injury
Feasibility of Action Observation Training [AOT] in Infants After Unilateral Brain Lesion
The study examines whether infants with a perinatal unilateral brain lesion can perform an "Action Observation Training" [AOT] at the age of 9-12 months .
- Trial name
- NCT04194281
- Testing
- Action Observation Training [AOT]
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Palsy, Cerebral Palsy, Spastic
Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy
Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations.
- Trial name
- HABIT-ILE (NCT07253857)
- Testing
- GROUP -A , Hand and Arm Bimanual Intensive Therapy Including Lower Extremity, GROUP-B , Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Cerebral Palsy
Efficacy of New Protocols in the Treatment of Upper Limb Dysfunctions in Patients With Cerebral Palsy
Cerebral palsy (CP) is the most common childhood motor disability. Weakness, spasticity, and loss of dexterity are the major problems in patients with CP.
- Trial name
- NCT02039284
- Testing
- SES, VCT, VRCIT
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- Chang Gung Memorial Hospital
Cerebral Palsy, Diplegia
Effect of Upper Extremity Functional Skills on Quality of Life and Participation of the Children With Cerebral Palsy
Cerebral palsy (CP) is a movement and posture disorder accompanied by sensory, perception, cognition, communication and behavioral disorders that cause activity limitations by causing various non-progressive disorders of the…
- Conditions
- Cerebral Palsy, Diplegia, Upper Extremity Dysfunction, Quality of Life
- Trial name
- CP (NCT05194319)
- Testing
- All assessments of children (Demographic information, upper extremity skills, quality of life and participation levels)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sanko University
Arthroplasty, Replacement, Hip
Evaluation of Four Surgical Techniques in Primary Total Hip Arthroplasty
Current "Minimally Invasive THR" includes: (1) Minimally Invasive Two-Incision THR (MIS-2), (2) Minimally Invasive Modified Watson-Jones THR (MIS-WJ).
- Trial name
- NCT01031732
- Testing
- MIS-2 THA, MIS-WJ, MIS-AL THA
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Hemiplegic Cerebral Palsy
Electromyography Biofeedback Training Versus Mirror Therapy on Muscle Activity, Range of Motion and Function of Upper Limb in Children With Hemiplegia
One of the main motor control issues in hemiplegic CP is spasticity, which affects the flexor muscles of the upper limb. This spasticity causes the limb to adopt a flexed posture, limiting the range of motion and contributing to…
- Trial name
- NCT07818616
- Testing
- Neurotrac Simplex electromyography biofeedback device, Mirror, a designed physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cerebral Palsy
Soft Tissue Release for Elbow Pronation in Cerebral Palsy
Upper extremity deformities are highly common in individuals with cerebral palsy (CP) as a result of motor control impairment and muscle imbalance.
- Trial name
- NCT07601165
- Testing
- Upper extremity soft-tissue release
- Volunteers
- 28 people
- Sponsor
- Istanbul University - Cerrahpasa
Ataxia, Spinocerebellar, Ataxias, Hereditary
Functional Trunk Training in Ataxia Patients
The study is to examine the effect of functional trunk training on trunk control and upper extremity functions in patients with autosomal recessive ataxia.
- Trial name
- NCT04740359
- Testing
- Functional training, Routine training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hasan Kalyoncu University
Cerebral Palsy
Project Falcon: Exploring a Virtual Reality-based Video Game for Young People With Cerebral Palsy
This study seeks to 1) adapt a low-cost controller, the Novint Falcon, and a set of video games that would provide rehabilitative feedback for young people with cerebral palsy, and 2) explore feasibility of the Falcon system and…
- Trial name
- NCT04298411
- Testing
- Falcon
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Effects of CHRIST on Upper Limb Function in Children With Pediatric Stroke
Pediatric stroke poses significant challenges due to its impact on a child's developing brain. Both ischemic and hemorrhagic strokes in children can result in long-term motor, sensory, and cognitive impairments, particularly…
- Trial name
- NCT07441057
- Testing
- CHRIST
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
Cerebral Palsy, Respiratory Function
Inspiratory Muscle Training in Children With Cerebral Palsy: Effects on Respiratory and Motor Functions
This study investigates the effect of inspiratory muscle training on respiratory parameters, trunk control, upper extremity function and swallowing in patients with cerebral palsy aged 5-18 years.
- Conditions
- Cerebral Palsy, Respiratory Function, Balance, Swallowing
- Trial name
- NCT07041593
- Testing
- Inspiratory muscle training and standard neurodevelopmental physiotherapy (SNP), Standard neurodevelopmental physiotherapy (SNP)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Sadık Emre ÇELEBİ
Mental Health, Socio-emotional Well-being
Combining Mental Health and Parenting Interventions to Improve Child Wellbeing Among Refugee Families in Tanzania
The goal of this clinical trial is to learn whether improving caregivers' mental health and parenting practices can enhance child wellbeing among Congolese refugee families living in the Nyarugusu Refugee Camp, Tanzania.
- Conditions
- Mental Health, Socio-emotional Well-being, Functioning, Psychosocial, Parenting Behavior
- Trial name
- WEMA (NCT07447921)
- Testing
- Self Help Plus, Interaction Competencies with Children - for Parents
- Where
- 2 sites in Tanzania
- Volunteers
- 1,296 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Cerebral Palsy (CP)
Constraint-induced Movement Therapy Combined With Functional Electrical Stimulation in Children With Cerebral Palsy
This randomized controlled trial aims to compare the effectiveness of Constraint-Induced Movement Therapy (CIMT) combined with Functional Electrical Stimulation (FES) versus CIMT alone in improving upper limb function, reducing…
- Trial name
- CIMT-FES-CP (NCT07587476)
- Testing
- Constraint-Induced Movement Therapy Combined with Functional Electrical Stimulation, Constraint-Induced Movement Therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Montiha Azeem