Clinical trials: Urinary Bladder
Neurogenic Bladder
Botox Versus Oxybutynin as First Line Treatment for the Poorly Compliant Pediatric Neurogenic Bladder
The purpose of this study is to investigate the use of Botulinum Toxin A as primary therapy for children with neurogenic bladder due to spina bifida and compare results with standard oral oxybutynin therapy.
- Trial name
- NCT01716624
- Testing
- Oxybutynin, Botulinum Toxin A injection
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Vesico-vaginal Fistula
Treatment of Vesico-vaginal Fistula by a Robot Assisted Laparoscopy : Results of a Multicentric Series (FFVLARO)
Robot-assisted Vesico-Vaginal fistula (VVF) repair was described a few years ago as an alternative to the open approach to minimize the morbidity of this surgery.
- Trial name
- FFVLARO (NCT04172389)
- Testing
- vesico-vaginal fistula robot assisted laparoscopic repair
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Overactive Bladder Syndrome
Colonization of the Female Urethra With Mycoplasma Hominis, Ureaplasma Urealyticum, Chlamydia Trachomatis, or Neisseria Gonorrhea in Patients With Lower Urinary Tract Symptoms
The purpose of this study is to assess the prevalence of mycoplasma hominis, ureaplasma urealyticum, neisseria gonorrhea, and chlamydia trachomatis in women with overactive bladder symptoms, and to correlate these findings with…
- Trial name
- NCT01559623
- Testing
- retrospective data analysis
- Where
- Switzerland
- Volunteers
- 766 people
- Sponsor
- University of Zurich
Voiding Dysfunction
The Measurement of Bladder Impedance and Heart Rate During Urodynamic Study
Purpose To measure the impedance of the bladder during the urodynamic study to see if changes in the impedance value occur as the bladder volume changes in pediatric patients aged 5-12 years along with its leg time.
- Trial name
- NCT04010591
- Testing
- impedance measurement during urodynamic study
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Overactive Bladder
Urinary Neurotrophin Levels in Healthy Children
The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who…
- Trial name
- NCT02389270
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Zagreb
Overactive Bladder Syndrome, Voiding Dysfunction
Cystoscopy Plus Urethral Dilatation Versus Cystoscopy Alone in Women With Overactive Bladder Syndrome and Impaired Voiding
Urethral dilatation is a commonly undertaken intervention for a variety of urinary complaints including overactive bladder symptoms. There is however very little evidence for its efficacy, and no randomized trial evidence.
- Trial name
- NCT00839969
- Testing
- Cystoscopy, Cystoscopy and urethral dilatation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Medway NHS Foundation Trust
Bladder Adenocarcinoma, Bladder Squamous Cell Carcinoma
Neoadjuvant Intravesical Vaccine Therapy in Treating Patients With Bladder Carcinoma Who Are Undergoing Cystectomy
This phase I trial studies the side effects and best dose of vaccine therapy given directly into the bladder in treating patients who are undergoing surgery to remove all or part of the bladder.
- Conditions
- Bladder Adenocarcinoma, Bladder Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Recurrent Bladder Carcinoma
- Trial name
- NCT00072137
- Testing
- Recombinant Fowlpox-TRICOM Vaccine, Recombinant Fowlpox GM-CSF Vaccine Adjuvant, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer, Urethral Cancer
Short-Term Low-Dose Interferon Alfa in Treating Patients With Cancer of the Urothelium
RATIONALE: Interferon alfa may interfere with the growth of tumor cells and slow the growth of urothelial cancer. PURPOSE: This randomized phase I trial is studying how well low-dose interferon alfa works in treating patients…
- Trial name
- NCT00082719
- Testing
- Recombinant Interferon Alfa
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pediatric Urology
Diagnostic Performance of PIC Cystogram vs VCUG in Children
The goal of this interventional diagnostic clinical trial is to evaluate and compare the diagnostic effectiveness of PIC cystography and voiding cystourethrography (VCUG) for the detection of vesicoureteral reflux (VUR) in…
- Trial name
- NCT07334821
- Testing
- PIC cystography, VCUG
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tarik Emre Sener
Point-of-Care Bladder Ultrasound, Urethral Catheter
BULLET: Bladder Ultrasound Limits Length (of Time), Expedites Treatment
In this study patients presenting to the pediatric ER with abdominal or pelvic complaints will be randomized to urethral bladder catheter or bladder ultrasound to compare time to completion of successful pelvic ultrasound, as…
- Trial name
- BULLET (NCT03860311)
- Testing
- Bladder Ultrasound, Standard of Care
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Neurogenic Bladder, Urinary Retention
Bacterial Properties With LoFric® Catheters During Clean Intermittent Catheterization
The primary objective of our study is to examine characteristics of bacteria that are discovered in urine from pediatric patients that utilize either LoFric® or non-LoFric® catheters for self intermittent catheterization.
- Trial name
- NCT01305681
- Testing
- LoFric® catheters during clean intermittent catheterization
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Primary Dystonia, Epilepsy
Assess Specific Kinds of Children Challenges for Neurologic Devices Study
The ASK CHILDREN study is intended to aid in future development of various neurologic devices (i.e. neuroprostheses). The ASK CHILDREN study seeks to use study information obtained to identify more efficient strategies in the…
- Conditions
- Primary Dystonia, Epilepsy, Hydrocephalus, Bladder Control
- Trial name
- NCT01191307
- Volunteers
- 16 people
- Sponsor
- Carlos Pena, PhD, MS
Pelvic Organ Prolapse, Cystocele
Native Tissue Repair in Pelvic Organ Prolapse -Long-term Results and Risk of Re-operation
This study evaluates the recurrence of pelvic organ prolapse and the rate of re-operation after primary surgery for anterior vaginal wall prolapse with native tissue repair in long term follow-up.
- Trial name
- NCT06744972
- Volunteers
- 392 people
- Sponsor
- Turku University Hospital
Overactive Bladder (OAB)
Transcutaneous Tibial Nerve Stimulation Therapy in Children With Overactive Bladder
Overactive bladder (OAB) is a syndrome characterized by urinary urgency, often accompanied by frequency and nocturia, with or without urge incontinence, without urinary tract infection or other clear pathological changes.
- Trial name
- NCT06765629
- Testing
- Non-invasive Percutaneous Tibial Nerve Stimulation (TTNS) group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Nocturnal Enuresis
Basic Bladder Advice and Alarm Therapy in Nocturnal Enuresis
Enuresis is the scientific term for bedwetting. Modern research has established three pathogenic mechanisms as crucial: 1. Excessive urine production at night (nocturnal polyuria). 2. Detrusor over activity.
- Trial name
- BAAT (NCT03812094)
- Testing
- Enurad 400, Basic Bladder advice
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Dalarna County Council, Sweden
Overactive Bladder
Acupuncture Combined With Mirabegron in the Treatment of OAB
Introduction: As conventional treatments for overactive bladder (OAB) have not yet shown satisfactory results, new approaches are needed.
- Trial name
- ACWMITTOOAB (NCT06181019)
- Testing
- 50 mg of mirabegron, acupuncture combined with mirabegron.
- Where
- China
- Volunteers
- 75 people
- Sponsor
- The Affiliated Ganzhou Hospital of Nanchang University
Bladder Cancer, Genitourinary Cancer
A Validation Study of MR Lymphangiography Using SPIO, a New Lymphotropic Superparamagnetic Nanoparticle Contrast
The goal of this clinical research study is to evaluate how well ferumoxtran-10, a new Magnetic Resonance Imaging (MRI) contrast agent, can detect cancer in the pelvic lymph nodes or malignant pelvic lymph nodes.
- Conditions
- Bladder Cancer, Genitourinary Cancer, Prostate Cancer
- Trial name
- NCT00147238
- Testing
- Ferumoxtran-10 (USPIO), MR lymphangiography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Muscle-invasive Bladder Urothelial Carcinoma
A Phase II Study of Toripalimab Plus RC48-ADC With Radiotherapy for Bladder Preservation in HER2-Positive Muscle-Invasive Bladder Cancer
This is a prospective, open-label, single-center, single-arm clinical study. Plans to enroll 45 MIBC patients with clinical stage T2-T4aN0M0 and HER2-positive (IHC 1+/2+/3+) status.
- Trial name
- NCT07279597
- Testing
- RC48-ADC + Toripalimab
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Breast Cancer, Prostate Cancer
Tempus Priority Study: A Pan-tumor Observational Study
Observational study that will be collecting clinical and molecular health information from cancer patients who have received comprehensive genomic profiling and meet the specific eligibility criteria outlined for each cohort with…
- Conditions
- Breast Cancer, Prostate Cancer, Bladder Cancer, Lung Cancer
- Trial name
- NCT05179824
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tempus AI