Clinical trials: Vaccine Response Impaired
Malnutrition, Child, Enteropathy
Study of Environmental Enteropathy and Malnutrition in Pakistan
Environmental Enteropathy (EE) is an acquired sub-clinical inflammatory gut condition in which alterations in intestinal structure, function, and local and systemic immune activation lead to impaired vaccine responses, decreased…
- Conditions
- Malnutrition, Child, Enteropathy, Vaccine Response Impaired, Stunting
- Trial name
- SEEM (NCT03588013)
- Testing
- Nutritional education, Ready to Use Therapeutic Food, Upper gastrointestinal endoscopy with biopsy
- Where
- Pakistan
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Arsenic--Toxicology, Immunologic Disorders Complicating Pregnancy
Pregnancy, Arsenic and Immune Response
As the global availability of vaccines increases, and reaches areas disproportionately affected by arsenic and malnutrition, resolving questions about potential environmental and biologic barriers to maternal immunization has…
- Conditions
- Arsenic--Toxicology, Immunologic Disorders Complicating Pregnancy, Vaccine Response Impaired, Micronutrient Deficiency
- Trial name
- PAIR (NCT03930017)
- Testing
- Seasonal influenza vaccine - VAXIGRIP TETRA influenza vaccine (quadrivalent, split virion, inactivated)
- Where
- Bangladesh
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Rotavirus Infection, Vaccine Response Impaired
The Effects of Increased Inoculum on Oral Rotavirus Vaccine Take and Immunogenicity
Rotavirus is the leading cause of diarrhea in children worldwide. Oral rotavirus vaccines work remarkably well in high-income countries, but for unclear reasons they underperform in low-income countries.
- Conditions
- Rotavirus Infection, Vaccine Response Impaired, Vaccine Virus Shedding
- Trial name
- NCT02992197
- Testing
- Rotarix, dose 1, Rotarix, dose 2
- Where
- Bangladesh
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Vaccine Response Impaired
Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines
This study evaluates seroconversion against measles, mumps, rubella and yellow fever following vaccination. One-third of children will receive both yellow fever and measles, mumps, and rubella (MMR) vaccines on the same day; one…
- Trial name
- NCT03368495
- Testing
- Co-administration of MMR/YF, MMR followed by YF, YF followed by MMR
- Where
- 4 sites in Argentina
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Alba Maria Ropero