Clinical trials: Vaginal Microbiome
Sexually Transmitted Infection, HIV/AIDS
Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)
This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes.
- Conditions
- Sexually Transmitted Infection, HIV/AIDS, Cost-effectiveness, Birth Outcomes
- Trial name
- NCT04446611
- Testing
- First antenatal care + test-of-cure, First antenatal care + week 30-34 gestation (no test-of-cure)
- Where
- South Africa
- Volunteers
- 2,247 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Recurrent Urinary Tract Infection, Genitourinary Syndrome of Menopause
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women with Recurrent Urinary Tract Infections
Recurrent urinary tract infection (rUTI) is a common and difficult to treat problem with limited treatment option; postmenopausal women are disproportionately affected.
- Trial name
- UTIEXTERMINATE (NCT06124820)
- Testing
- Deka SmartXide Touch C60 (MonaLisa Touch)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- King's College Hospital NHS Trust
Overactive Bladder (OAB), Menopause
Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder
The goal of this Pre-Post Quasi-experimental study is to investigates the effect of vaginal estrogen therapy on changes in the urinary microbiome and its association with improvement in overactive bladder (OAB) symptoms in…
- Conditions
- Overactive Bladder (OAB), Menopause, Microbiome
- Trial name
- NCT06780163
- Testing
- 17β-estradiol 10 mcg
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Urinary Tract Infections, Vaginal Flora Imbalance
Vaginal Care System for Menopausal Women With Urinary Tract Infections
Menopausal women have an increased risk of recurrent urinary tract infections. This is likely due in part to hormonal changes occurring during menopause.
- Trial name
- NCT05573334
- Testing
- BioNourish
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vaginal Biome Science
Vaginal Microbiome
The Maggie Project: Exploring the Origin and Heredity of the Vaginal Microbiome
The vaginal microbiome plays a crucial role in women's health and reproduction, impacting not only women but also their partners and children. However, its ecology and primary colonizers are not well understood.
- Trial name
- Maggie (NCT06912126)
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Urinary Tract Infections, Menopause
Characterization of Vaginal, Urinary and Fecal Microbiomes in Women With Recurrent Urinary Tract Infections
The objectives are to evaluate whether variations in vaginal and/or urinary and/or fecal microbiome predispose postmenopausal women to recurrent cystitis.
- Trial name
- NCT04305808
- Where
- Israel
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bacterial Vaginosis, Vaginal Microbiome
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV.
- Conditions
- Bacterial Vaginosis, Vaginal Microbiome, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
- Trial name
- POWWERHealth (NCT05666778)
- Testing
- Menstrual Cup
- Where
- 2 sites in United States, Kenya
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cesarean Delivery Affecting Newborn, Obesity, Childhood
Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.
Neonates delivered by scheduled Cesarean Section will be randomized to receive vaginal seeding (exposing the infant to Mother's vaginal flora) or sham.
- Conditions
- Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome, Microbiota
- Trial name
- NCT03298334
- Testing
- Vaginal Seeding, No Vaginal Seeding
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dysbiosis, Inflammation Gum
Microbiome Alterations With Xylitol (MAX) in Pregnancy
The purpose of this study is to understand if chewing xylitol-gum initiated before 20 weeks of pregnancy and continued until delivery affects the bacteria that are found in the oral and vaginal cavities, signs of inflammation…
- Conditions
- Dysbiosis, Inflammation Gum, Placenta-mediated Pregnancy Complications, Microbioata
- Trial name
- MAX (NCT06329596)
- Testing
- Xylitol gum, Sorbitol gum
- Where
- Malawi
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Preterm Birth
Motherhood and Microbiome
This is a prospective cohort, enriched with women with a prior term birth, of singleton pregnancies who will be followed for the outcome of preterm birth.
- Trial name
- M&M (NCT02030106)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Pennsylvania
Microbial Colonization
Collection of Microbiome Samples of Healthy Western Donors for Fundamental and Functional Microbiome Research
Large numbers of micro-organisms (especially bacteria) live in and on human bodies and have a very important function for the health. These microorganisms are called 'the microbiota'.
- Trial name
- NCT06466707
- Testing
- Collection of microbiome samples
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Ghent
Vaginal Microbiome
Microbiome in Preterm Birth
The aims of this prospective longitudinal case-control pilot-study are (1) to characterize the changes of the vaginal, uterine and placental microbiome in pregnant women experiencing pPROM with immediate hospitalization and…
- Trial name
- NCT04489056
- Testing
- Swabs for microbiome analysis
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna