Clinical trials: Vagus Nerve Stimulation
Long COVID, Chronic Fatigue Syndrome
Vagus Nerve Stimulation as Treatment for Long Covid
Many patients do not recover following Covid infection. The resulting illness is called Long Covid. Because there is no agreed upon treatment for this ailment, the research team has decided to do an open label pilot study using…
- Trial name
- NCT05608629
- Testing
- Transcutaneous Non-Invasive Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Tuberous Sclerosis Complex, Epilepsy
The Effectiveness and Safety of Vagus Nerve Stimulation for TRE
Prospective cohort studies to identify clinical epilepsy control, cognitive changes, and safety of VNS in patients with tuberous sclerosis complex-related epilepsy.
- Trial name
- NCT04198207
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Beijing Children's Hospital
Cerebral Palsy
Paired Non-invasive VNS in Adolescent Cerebral Palsy Rehabilitation
This is an open-label safety and feasibility trial evaluating the use of paired non-invasive vagus nerve stimulation (VNS) and upper extremity (UE) rehabilitation in the motor impairment reduction of adolescent patients with…
- Trial name
- NCT07394608
- Testing
- Non-invasive taVNS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Epilepsy
VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37)
Obtain baseline clinical outcome data (Stage 1) upon which to base a subsequent study (Stage 2) of the Model 106 VNS implantable pulse generator
- Trial name
- E-37 (NCT01846741)
- Testing
- M106 VNS Therapy System
- Where
- 15 sites in United States
- Volunteers
- 20 people
- Sponsor
- Cyberonics, Inc.
Emergence Agitation, Emergence Delirium
Transcutaneous Auricular Vagus Nerve Stimulation for Prevention of Emergence Agitation and Delirium in Children Undergoing Tonsillectomy and Adenoidectomy
Brief Summary This study is designed to find out whether transcutaneous auricular vagus nerve stimulation (taVNS) can safely reduce restlessness and confusion when children wake up from anesthesia after tonsillectomy and…
- Trial name
- NCT07394647
- Testing
- Active taVNS Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Efficacy, Self, Fatigue; Muscle, Heart
Neuromodulation of the Autonomic Nervous System in Athletes
There are few studies in the literature that have evaluated the effects of using percutaneous stimulation of the auricular branch of the vagus nerve for sports purposes (to accelerate recovery after physical exertion).
- Conditions
- Efficacy, Self, Fatigue; Muscle, Heart, Fatigue, Mental, Fatigue; Combat
- Trial name
- NANSA (NCT06281795)
- Testing
- tVNS
- Where
- Russia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Tourette Syndrome, Chronic Tic Disorder
Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Tic Disorders/Tourette's Syndrome in Children and Adolescents
The objective of this trial is to evaluate the effect of transcutaneous auricular vagus nerve stimulation compared to sham stimulation in improving chronic tic disorder or Tourette's syndrome in children and adolescents.
- Trial name
- NCT07854665
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Premature Birth, Breastfeeding, Exclusive
taVNS-Paired Breastfeeding to Improve Breastfeeding at Discharge
Investigators aim to improve the skills of premature or sick term infants in breastfeeding by boosting motor learning with transcutaneous vagus nerve stimulation.
- Conditions
- Premature Birth, Breastfeeding, Exclusive, Feeding; Difficult, Newborn
- Trial name
- NCT06417385
- Testing
- taVNS soterix device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Prader-Willi Syndrome
A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
The goal of the VNS4PWS clinical study is to test the efficacy, safety, and acceptability of transcutaneous vagus nerve stimulation (tVNS) treatment in people with PWS.
- Trial name
- VNS4PWS (NCT06144645)
- Testing
- tVNS, intermittent stimulation, tVNS, continuous stimulation
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- Foundation for Prader-Willi Research
Epilepsy
Optimization of the Parameters of Vagal Nerve Stimulation
Vagal nerve stimulation (VNS) is one of the neuromodulation techniques that can be indicated in patients suffering from refractory epilepsies, especially when an open resection has failed or is not indicated.
- Trial name
- OPSTIMVAG (NCT04693221)
- Testing
- Choice of VNS set of parameters based on the lowest PLI, EEG
- Where
- 18 sites in France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Primary Dysmenorrhea (PD)
Effects of Transcutaneous Tibial and Auricular Vagus Nerve Stimulation in Females With Primary Dysmenorrhea
Primary dysmenorrhea is a common gynecological condition characterized by painful menstrual cramps that can negatively affect daily activities and quality of life.
- Trial name
- NCT07834658
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS), Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), TTNS+TaVNS
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Cerebral Palsy
Non Invasive Vagus Nerve Stimulation in Cerebral Palsy (BOOSTTVNS)
The present study aims to assess, through a randomized controlled trial (RCT), the efficacy of transcutaneous Vagus Nerve Stimulation (tVNS) in enhancing the functional changes due to an intensive motor training in children and…
- Trial name
- (BOOSTTVNS) (NCT06372028)
- Testing
- transcutaneous vagus nerve stimulation (tVNS)
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- IRCCS Eugenio Medea
Feeding Delays, Neonates and Term Infants
BabySTrong II taVNS Feeding Trial
The long-term goal of this project is to develop a therapy to assist pre-term and term infants with brain injury overcome difficulties in learning to feed so that infants may be discharged home with their families and avoid the…
- Trial name
- BabySTrong II (NCT07049952)
- Testing
- taVNS, NAC and taVNS, inactive taVNS
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Medical University of South Carolina
Juvenile Idiopathic Arthritis (JIA)
Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA
The study is a multicenter, double-blind, sham-controlled trial to evaluate the safety and effectiveness of tcVNS on pain and inflammation associated with JIA.
- Trial name
- AJA01 (NCT05710640)
- Testing
- Active tcVNS
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Cerebral Palsy, Spastic
Nervus Vagus Stimulation and Cerebral Palsy
This study investigated the acute effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic nervous system regulation and spasticity in children with spastic cerebral palsy.
- Trial name
- NCT06880887
- Testing
- nervus vagus stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medipol University Hospital
Crohn Disease, Ulcerative Colitis
Transcutaneous VNS to Treat Pediatric IBD
The current available therapies for inflammatory bowel disease (IBD), including immunomodulator and biologic medications may have toxicities limiting use or inadequate effect.
- Trial name
- STIMIBD (NCT03863704)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Hypoxia-Ischemia, Brain
Transauricular Vagus Nerve Stimulation in Children
The goal of this clinical trial is to learn about brain waves during transauricular vagus nerve stimulation (taVNS) in healthy children.
- Trial name
- NCT06168071
- Testing
- taVNS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Narcolepsy Type 1, Fmri
Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Narcolepsy Type 1
The study aimed to examine the efficacy and safety of tVNS as a complementary approach for NT1 by conducting a double-blind, randomized, sham-controlled trial.
- Trial name
- NCT06241911
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liu Yonghong
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina