Clinical trials: Validation Study
Ophthalmological Disorder
Development and Validation of a Deep Learning System for Multiple Ocular Fundus Diseases Using Retinal Images
Retinal images can reflect both fundus and systemic conditions (diabetes and cardiovascular disease) and firstly to be used for medical artificial intelligence (AI) algorithm training due to its advantages of clinical…
- Trial name
- NCT04213430
- Testing
- diagnostic
- Where
- China
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Clinical Indication for Brain MRI, Healthy Volunteers
Comparative Study of Conventional MR Images With Synthetically Reconstructed MR Images of the Brain
This study is being conducted for evaluation of 3D Synthetic MRI (SyMRI 15, 3D) for neuroimaging,
- Trial name
- NCT05425927
- Testing
- SyMRI 15 (3D)
- Where
- 6 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- SyntheticMR
Hearing Loss
Littlears Auditory Questionnaire: Validation Study in CI Children
The LittlEARS Auditory Questionnaire is designed to assess the development of the auditory behavior in children during the first two (hearing) years.
- Trial name
- LittlEars (NCT00785707)
- Where
- 5 sites in United States
- Volunteers
- 31 people
- Sponsor
- Med-El Corporation
Validation Studies, Psychiatric Diagnosis
Digitizing and Automating the Diagnostic Psychiatric Assessment Process
This is an observational study that will be responsible for the Spanish translation and cross-cultural adaptation, and validation of the Electronic Semi-Structured Psychiatric Interview for Children and Adolescents (EPSI-C), to…
- Trial name
- DADAP (NCT07468214)
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Irene Lopez Armenteros
Treatment Outcome, Muscle Dystonia
Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study
This project will determine the feasibility and validity of measuring elbow muscle flexor stiffness in a population of patients with sub-acute severe acquired brain injury using two measurement methods, the portable spasticity…
- Conditions
- Treatment Outcome, Muscle Dystonia, Spasticity, Muscle, Muscle Tightness
- Trial name
- NCT04207632
- Testing
- Botulinum toxin type A injection
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fluid Status, Peritoneal Dialysis
Bioimpedance as a Tool for Fluid Management in Peritoneal Dialysis (PD) Patients
Hypothesis: The investigators hypothesize that regular monitoring of BIA adds value to the management of fluid status in PD patients Objectives of the study: The objective is to show that in patients where the additional…
- Trial name
- NCT00801112
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospital of North Staffordshire
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Jaundice, Neonatal
Screening for Neonatal Jaundice With a Mobile Health Device: a Validation Study in Oaxaca, Mexico.
The performance and accuracy of the smartphone application (app) Picterus Jaundice Pro (PicterusJP) will be validated by a cross-sectional study conducted in low resource settings in Mexico.
- Trial name
- NCT06276582
- Testing
- Screening for neonatal jaundice with a mobile health device
- Where
- Mexico
- Volunteers
- 177 people
- Sponsor
- Norwegian University of Science and Technology
Matched-Pair Analysis, Blood Gas Analysis
Mathematical Arterialization of Venous Blood Gas
Objective: Arterial blood gas (ABG) analysis is essential in the clinical assessment of potential acutely ill patients. Venous to arterial conversion (v-TAC), a mathematical method, has recently been developed to convert…
- Conditions
- Matched-Pair Analysis, Blood Gas Analysis, Emergency Service, Hospital
- Trial name
- NCT03309410
- Testing
- Venous to arterial conversion (v-TAC)
- Volunteers
- 30 people
- Sponsor
- Aalborg University
Cystic Fibrosis
The iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibrosis
The progression of lung disease in cystic fibrosis (CF) results inevitably in a reduction in exercise capacity. The assessment of fitness and exercise capacity in CF is an important measure of the impact of the disease process…
- Trial name
- NCT02199340
- Testing
- iStep exercise test, CPET exercise test
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Brain Diseases
Clinical Validation Study of Multi-EPI Mix
This study aims to assess the diagnostic validity of a new minute-MRI sequence for neuroradiological evaluation in comparison to conventional MRI.
- Trial name
- NCT03338270
- Testing
- MRI
- Where
- Sweden
- Volunteers
- 101 people
- Sponsor
- Karolinska University Hospital
Neonatal Brachial Plexus Palsy
Validation Study Of A Digital Measuring Device For Central Hand Representation In Children With A Neonatal Brachial Plexus Palsy
Hand function is one of the most complex and sophisticated sensorimotor skills, controlled by the interplay of precise motor efferent and multisensory afferent stimuli.
- Trial name
- NCT06950879
- Testing
- Measurement
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Ghent
Urinary Sodium Excretion, Salt Intakes
Estimation Method of 24-hour Urinary Sodium Excretion by Using Spot Urine for Chinese Population
The accurate evaluation of daily salt or sodium intake is difficult to implement in clinical practice and large epidemiological studies.
- Trial name
- NCT03204422
- Testing
- No intervention
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Beijing Children's Hospital
Pediatric Cancer
Cross-cultural Adaptation and Validation of the P-CIN for Chinese Pediatric Oncology Patients
The goal of this study was to conduct a cross-cultural adaptation of the P-CIN into the Chinese context, assess its psychometric properties, and determine the cut-off value of CIPN among Chinese pediatric oncology patients.
- Trial name
- NCT07053579
- Where
- 2 sites in Hong Kong
- Volunteers
- 313 people
- Sponsor
- The Hong Kong Polytechnic University
Musculoskeletal Diseases
Competency-based Assessment of Ultrasound-guided Joint Injection Skills
Ultrasound-guided joint injections and aspirations are frequently used in the treatment of rheumatological diseases. Studies have shown that intra-articular glucocorticoid injections (IAGCs) in the early treatment of rheumatoid…
- Trial name
- NCT05303974
- Testing
- Ultrasound guided joint injection
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HBV Reactivation, HSCT
HBV Reactivation Prediction Model in Allo-HSCT
Hepatitis B virus (HBV) reactivation is a serious complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT), particularly in patients with resolved HBV infection (HBsAg-negative, anti-HBc-positive).
- Trial name
- HBV-post HSCT (NCT07644026)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 300 people
- Sponsor
- Xiao Hui Zhang
Quality of Life, Spinal Deformity
The Turkish Adaptation, Validity and Reliability Study of the Quality of Life Profile for Spinal Deformities
The purpose of this study is to translate and culturally adapt the quality of life profile for spinal deformities (QLPSD) to Turkish language and test the validity and reliability of Turkish version of QLPSD in patients with…
- Conditions
- Quality of Life, Spinal Deformity, Scoliosis
- Trial name
- NCT04846296
- Testing
- Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pre-Term, Breast Milk Expression
Preemie Milk Analyser Validation Study
This study aims to test and validate the Preemie Ecosystem- a new device and associated software package for measuring the nutrient (fat, protein and carbohydrate) content of the breast milk of the mothers of premature babies.
- Conditions
- Pre-Term, Breast Milk Expression, Nutrition Disorder, Infant
- Trial name
- NCT06486194
- Testing
- Targeted breast milk fortification using preemie device, Standard Breast milk fortification
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cutaneous Lymphoproliferative Diseases, Mycosis Fungoides of Skin (Diagnosis)
Development of an AI-Assisted Diagnostic Tool for Mycosis Fungoides and Other Cutaneous Lymphoproliferative Diseases Using Microscopic Image Analysis: A Training and Validation Study
Cutaneous lymphoproliferative diseases (CLPDs) are a group of skin disorders that range from benign conditions, such as pseudolymphomas, to malignant forms like cutaneous T-cell and B-cell lymphomas.
- Conditions
- Cutaneous Lymphoproliferative Diseases, Mycosis Fungoides of Skin (Diagnosis), T Cell Dyscrasia, PLEVA-PLC Spectrum
- Trial name
- NCT07705386
- Testing
- AI-assisted histopathology image analysis
- Where
- Egypt
- Volunteers
- 463 people
- Sponsor
- Cairo University
Magnetic Resonance Imaging
Prospective Study Assessing the Validity of Y-PAS (Yale Preoperative Anxiety Scale) to Predict Patients Undergoing Magnetic Resonance Imaging Without the Use of Sedation/General Anesthesia
The mYPAS (Modified Yale Preoperative Anxiety Scale) is a quick, easy, validated and "gold standard" assessment tool to measure pediatric anxiety in the perioperative period.
- Trial name
- NCT02586103
- Testing
- MRI simulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Arlyne Thung