Clinical trials: Valve
Hypertrophic Cardiomyopathy (HCM)
ReGistry of hypeRtrophic cArDIomyopathy: Regional fEatures, geNeTics and Course
This study is envisioned as the very first of its kind in the Russian Federation, aiming to provide a comprehensive characterization of the clinical spectrum and disease burden, focusing on the epidemiology and progression of HCM…
- Trial name
- GRADIENT (NCT07295613)
- Where
- 2 sites in Russia
- Volunteers
- 1,400 people
- Sponsor
- Central State Medical Academy
Urethral Obstruction
Standardized Prenatal Clinical Care for LUTO
The investigators propose a standardized prenatal management, based on the scientific evidence published in the literature, to manage prenatally fetuses with lower urinary tract obstruction (LUTO).
- Trial name
- NCT02315521
- Testing
- Fetal Intervention for LUTO
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Aortic Stenosis
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement
To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.
- Trial name
- NCT03735667
- Testing
- ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System
- Where
- 75 sites in United States, Canada
- Volunteers
- 1,948 people
- Sponsor
- Boston Scientific Corporation
Emphysema
Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment
Rationale: Chronic obstructive pulmonary disease (COPD) is characterised by a high prevalence of peripheral muscle dysfunction, which can have significant clinical consequences, including decreased exercise capacity, reduced…
- Trial name
- ENDURANCE (NCT06025500)
- Testing
- 31P-Magnetic Resonance Spectroscopy (31P-MRS)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Aortic Stenosis, Calcific
Feasibility of Continuous Noninvasive Finger Arterial Blood Pressure Measurement for Detection and Staging of Aortic Stenosis
The primary purpose of this study is electronic data collection of arterial pressure waveform signals in patients with Aortic Stenosis.
- Trial name
- COaRt (NCT03088787)
- Testing
- Nexfin measuremtents
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diseases of Mitral Valve, Tricuspid Valve Disorder
Natural History of Melody Valve in the Mitral and Tricuspid Position
The Melody valve has historically been used for pulmonary valve replacements; however it has been more recently used in the mitral and tricuspid positions.
- Trial name
- NCT02505074
- Testing
- Valve replacement with the Melody valve
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Sepsis, Neonatal
Comparison Between Split Septum and Mechanical Valve Needleless Connector in Preterm Babies
The goal of this clinical trial study is to compare the effectiveness between split septum and mechanical valve needleless connector in very preterm babies (or under 1500 grams) The main questions it aims to answer are: What is…
- Trial name
- NCT06414174
- Testing
- Split septum needleless connector, Mechanical valve needleless connector
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Aortic Valve Surgery
10 Versus 20 Minutes Treatment of Human Pericardium With Glutaraldehyde in OZAKI Procedure
To compare mechanic and thermic stability of pericardium fixated either with 0.6% glutaraldehyde for 10 minutes or with 0.6% glutaraldehyde for 20 minutes
- Trial name
- 10vs20-OZAKI (NCT03667235)
- Testing
- Treatment of human pericardium with glutaraldehyde in OZAKI procedure, Treatment of human aortic valve tissue with glutaraldehyde
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Hospital, Basel, Switzerland
Emphysema or COPD
Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia
Rationale: The Chartis® ( Pulmonx, CA, USA) measurement system is a tool to assess interlobar collateral ventilation during bronchoscopy.
- Trial name
- NCT03205826
- Testing
- Type of sedation used
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Aortic Stenosis
PARTNER II Trial: S3iCAP
Following completion of enrollment in the PARTNER II SAPIEN 3 intermediate risk trial, this trial provided continued access to treatment for subjects with severe aortic stenosis who were at intermediate surgical risk.
- Trial name
- PII S3i CAP (NCT02687035)
- Testing
- SAPIEN S3 valve
- Where
- 56 sites in United States, Canada
- Volunteers
- 1,822 people
- Sponsor
- Edwards Lifesciences
Right Ventricular Outflow Tract Dysfunction
Observational Study of Venus P-Valve
Real-world evidence, retrospective and prospective, non-randomized, multicenter observational study of VenusP-ValveTM System in treating moderate or greater pulmonary regurgitation with/without pulmonary stenosis in patients with…
- Trial name
- Registry (NCT05835349)
- Testing
- transcatheter pulmonary valve implantation (TPVI)
- Where
- 10 sites in France, Germany and 2 more
- Volunteers
- 200 people
- Sponsor
- Venus MedTech (HangZhou) Inc.
Mitral Stenosis
Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
- Trial name
- NCT06067815
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cardiomyopathy, Hypertrophic
Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy
DDD pacing improves symptoms and relieves LV outflow tract (LVOT) obstruction in most patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00001530
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hydrocephalus
Safety and Performance of the Polaris® 24 Adjustable Valve System in Hydrocephalus Patients' Treatment
The SAPPHYRE study is an ambispective (retrospective and prospective) PMCF study with the objective to evaluate the safety and performance of the Polaris® 24 adjustable valve system in the treatment of 126 patients with…
- Trial name
- SAPPHYRE (NCT04746625)
- Where
- 2 sites in France
- Volunteers
- 126 people
- Sponsor
- Sophysa
Heart Valve Diseases, Surgery
Individualised Follow-up After Valve Surgery
This study aims to investigate the effect of an intervention consisting of early, individualised outpatient follow-up after heart valve surgery on unplanned readmissions and death within 180-days after discharge.
- Conditions
- Heart Valve Diseases, Surgery, Readmission
- Trial name
- INVOLVE (NCT03053778)
- Testing
- Early follow-up
- Where
- Denmark
- Volunteers
- 1,414 people
- Sponsor
- Odense University Hospital
Valve Heart Disease
Bioprothetic Valve Versus Mechanical Valve of Bioprothetic Valve Versus Mechanical Valve
In this study, the investigators aim to use data identified through the hospital's integrated medical database and National Health Insurance database to explore the long-term performance and benefits of biological and mechanical…
- Trial name
- NCT06041308
- Testing
- valve
- Where
- Taiwan
- Volunteers
- 30,000 people
- Sponsor
- National Taiwan University Hospital
Rheumatic Mitral Valve Disease
Minimally Invasive Rheumatic Mitral Valve Surgery
Early outcome of minimally invasive rheumatic mitral valve surgery through periareolar versus submamary approach
- Trial name
- NCT05270590
- Testing
- minimally invasive rheumatic mitral valve surgery
- Volunteers
- 20 people
- Sponsor
- Assiut University
Valve Heart Disease, Valve Disease, Heart
Allogeneic Valve Transplantation
Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve.
- Conditions
- Valve Heart Disease, Valve Disease, Heart, Valve Disease, Aortic
- Trial name
- NCT06387446
- Testing
- Valve transplant
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
Hypertrophic Cardiomyopathy
Outcome of Different Pathogenic Mutations in Hypertrophic Cardiomyopathy
This is a prospective, single-center study to assess clinical phenotype and prognosis of different pathogenic mutations in Chinese patients with hypertrophic cardiomyopathy.
- Trial name
- NCT03726424
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices