Clinical trials: Variability
Type 1 Diabetes, Nutrition
Oat Flakes β-glucan on Glycemic Variability, Pancreatic Reserve, and Dyslipidemia Among Adolescents With Type 1 Diabetes
Chronic iron overload represents a significant morbidity in Transfusion dependent β-thalassemia (TDT) leading to various endocrine complications including diabetes.
- Trial name
- NCT07593105
- Testing
- Oat Flour
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Left Ventricular Hypertrophy
Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects…
- Trial name
- SPEC (NCT04644094)
- Testing
- Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Patients Receiving Prednisone
Pharmacokinetics of Prednisone in Adults
This is a monocentric study, in the Internal Medicine Service of Cochin Hospital, Paris. Our main objective is to determine the pharmacokinetic properties of prednisone, secondary objectives are to determine the covariates…
- Trial name
- Glucomad (NCT02274402)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatal Encephalopathy, Asphyxia Neonatorum
Heart Beat Variability in Neonatal Encephalopathy
This study will find out if analysing heartbeat in babies with brain injury, based on standard clinical monitors, can inform treatment decisions and monitor stress levels in real time
- Conditions
- Neonatal Encephalopathy, Asphyxia Neonatorum, Hypoxic-Ischemic Encephalopathy
- Trial name
- HeartBeat (NCT03179553)
- Where
- 5 sites in United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Neurofibromatosis Type I, Tuberous Sclerosis Complex
The Cognitive Variability in NF1 and TSC Monozygotic Twins
Both Neurofibromatosis type 1 (NF1) and Tuberous Sclerosis Complex (TSC) are highly heterogeneous diseases. Cognitive features seem to vary widely even between family members carrying the same mutation.
- Trial name
- COVANTT (NCT02436746)
- Where
- Netherlands
- Volunteers
- 116 people
- Sponsor
- Erasmus Medical Center
Diabetes Mellitus, Type 1, Cardiovascular Diseases
French National Cohort of People With Type 1 Diabetes
Cardiovascular (CV) diseases are the most frequent type 1 diabetes (T1D) complications. A recent epidemiological study showed that patients with T1D have a two-fold CV mortality risk, even in case of good glycemic control.
- Conditions
- Diabetes Mellitus, Type 1, Cardiovascular Diseases, Hypoglycemia, Patient Participation
- Trial name
- SFDT1 (NCT04657783)
- Where
- France
- Volunteers
- 15,000 people
- Sponsor
- Fondation Francophone pour la Recherche sur le Diabete
Pineal Tumor
Melatonin Replacement Therapy in Pinealectomized Patients
This is an open-label, single-arm, single-center, proof-of-concept study to assess the effects of melatonin on cardiac autonomic activity in melatonin non-proficient pinealectomized patients.
- Trial name
- NCT03885258
- Testing
- Melatonin Replacement Therapy
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo
Neonatal Adaptation
Effect of Immediate Skin-to-Skin Contact on Neonatal Heart Rate Variability After Cesarean Secton
At birth, both the newborn and the mother experience adaptive stress, which can be measured using objective physiological methods.
- Trial name
- HRV-SCENE (NCT07109076)
- Testing
- skin-to-skin contact, routine care
- Where
- Slovenia
- Volunteers
- 80 people
- Sponsor
- University Medical Centre Ljubljana
Insomnia, Delayed Sleep Phase Disorder
Blue-blocking Glasses for Sleep Disorders in Child and Adolescent Psychiatry
Sleep problems and regulation difficulties are frequent in the child and adolescent psychiatry population. Insomnia and delayed sleep-wake phase disorders (DSPWD) are highly prevalent, and risk factors for developing more severe…
- Conditions
- Insomnia, Delayed Sleep Phase Disorder, Hyperarousal, Transdiagnostic Psychopathology
- Trial name
- BATCAT-pilot (NCT07433491)
- Testing
- Blue-blocking glasses (BB-glasses) or real darkness from 9 p.m. to desired wake-up time + night mode setting on mobile phone, Control
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Fonna
Premature Birth
Environmental Stress and Individualized Sensorimotor Care on Autonomic Nervous System Activity in Premature Population
Autonomic nervous system (ANS) is an essential regulator for the homeostasis, circulatory and respiratory systems. Heart rate variability, under the dependence of the parasympathetic and orthosympathetic arms is a peripheral…
- Trial name
- NCT00451607
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Social Anxiety Disorder
Here we Test Out an Online Compassion Focused Intervention for Adolescents With Social Anxiety Disorder and Analyze Its Effect on (Self)Compassion, Emotion Regulation and Social Anxiety Symptoms, as Well as Heart Rate Variability.
Emotion regulation (ER) is a key competence developed mainly throughout adolescence. According to an evolutionary perspective, threat, drive, and soothing systems interact to achieve ER.
- Trial name
- CFT@TeenSAD (NCT07244198)
- Testing
- Compassion Focused Therapy
- Where
- Portugal
- Volunteers
- 49 people
- Sponsor
- University of Coimbra
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington
Cardiomyopathy, Dilated
Variability of Ventricular Mass, Volume, & Ejection Fraction in Pediatric Cardiomyopathy Patients-Pediatric Heart Network
This observational study will provide data (variations in ventricular size and function) that are essential to designing and conducting clinical trials.
- Trial name
- VVV (NCT00123071)
- Where
- 8 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Carelon Research
Fungal Infections
Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children
The main goal of this study is to see how the body breaks down an antifungal drug named posaconazole in children with certain cancers, blood disorders, or transplantation of bone marrow or similar blood cells.
- Trial name
- NCT02358499
- Testing
- Posaconazole
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pediatric Anxiety
Non-Wearable Audiovisual Distraction for Children's Medical Anxiety in the ED
Pediatric emergency department (ED) visits often cause significant anxiety and stress for young patients due to unfamiliar environments and invasive medical procedures.
- Trial name
- NCT07761637
- Testing
- Non-Wearable Audiovisual Distraction, Routine ED Care
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Heart Rate Variability, Sport
Autonomic Responses of Amateur Child Athletes to Aerobic Exercise Test
The aim of our study was to investigate the relationship between aerobic capacity, which will be revealed by aerobic exercise test, and HRV, blood pressure, heart rate and pulmonary function parameters in healthy children…
- Trial name
- NCT06549192
- Testing
- 20 meter shuttle run test
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Inonu University
Diabetes, Diabetes Mellitus, Type 1
Observational Study to Evaluate the Safety of Levemir® in Diabetes
This study is conducted in Africa, Asia, Europe, Japan and South America. The aim of this observational study is to evaluate the incidence of serious adverse reactions (SARs) while using Levemir® (insulin detemir) under normal…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PREDICTIVE™ (NCT00659295)
- Testing
- insulin detemir
- Where
- 13 sites in Belgium, Czechia and 11 more
- Volunteers
- 51,170 people
- Sponsor
- Novo Nordisk A/S
Development, Infant
The Effect of Maternal Scent on Sleep Wake States
This study will be a prospective, randomized controlled study, which aims to determine if a maternal scent intervention improves the sleep wake states, brain maturation, and heart rate variability in premature infants admitted to…
- Trial name
- NCT04301453
- Testing
- Maternal Scent
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Columbia University
Atrial Septal Defect
A Prospective Investigation of Pleth Variability Index (PVI) as a Dynamic Parameter of Fluid Responsiveness in Children
This study is designed to investigate the ability of pleth variability index (PVI) to non-invasively predict fluid responsiveness in mechanically ventilated children.
- Trial name
- NCT02276599
- Testing
- Volume expansion
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Brian Schloss
Obesity
Blood Glucose Variability in Obese Youth Participating in a Lifestyle Modification Program
The purpose of this study is to measure blood glucose variation in youth prior to and after participation in a healthy lifestyle intervention program.
- Trial name
- NCT02296034
- Sponsor
- Yale University