Clinical trials: Vasopressor Agents
Septic Shock, Refractory Shock
What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin
The ICU mortality rate of patients with septic shock was still high upto 54.1%.In first 6 hours of resuscitation, the goals of resuscitation in sepsis shock after adequate fluid resuscitation is MAP ≥65 mmHg.
- Trial name
- NCT03038503
- Testing
- Methylene Blue, Terlipressin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Shock, Mechanical Ventilation
Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation
The purpose of this study is to assess the effectiveness from early infusion of norepinephrine in pediatric patients submitted to mechanical ventilation for the use of sedative and analgesics drugs.
- Trial name
- NCT00894621
- Testing
- Norepinephrine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Unidade de Terapia Intensiva
Hypotension, Shock
Optimal VAsopressor titraTION Pilot Randomized Controlled Trial
The purpose of this research study is to determine if it is better to give vasopressors to patients to maintain a higher blood pressure target versus a lower blood pressure target.
- Trial name
- OVATION (NCT01800877)
- Testing
- Vasopressors
- Where
- 10 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Francois Lamontagne
Hip Fractures, Intraoperative Hypotension
Peri-operative Vasopressor Support in Patients Operated for an Acute Hip Fracture (AHF)
The incidence of hypotension perioperatively during operation of an acute hip fracture is unknown. As a surrogate factor the usage of vasopressor support is more adequate as the registration of vasopressor drugs are many times…
- Trial name
- NCT03497949
- Where
- Sweden
- Volunteers
- 997 people
- Sponsor
- Sahlgrenska University Hospital
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following…
- Trial name
- NCT07038746
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dr. George Luciuk
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Pediatric Patients With Hypotension
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) or reduction in sum norepinephrine (NE) equivalent dosing, at Hour 2 after the start of LJPC-501, in pediatric patients…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- NCT03431077
- Testing
- Angiotensin II
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- La Jolla Pharmaceutical Company
Transversus Abdominis Plane Block
Plasma Concentrations of Levobupivacaine With and Without Epinephrine in Transversus Abdominis Plane Blocks
The aim of this study is to determine the effect of the addition of vasoconstrictor in the plasma concentrations achieved and the extent of the transversus abdominis plane block in healthy male volunteers.
- Trial name
- NCT01596998
- Testing
- Levobupivacaine with epinephrine, Levobupivacaine without epinephrine, Monitoring
- Where
- Chile
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN)
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic…
- Conditions
- Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN), Hypoxemic Respiratory Failure
- Trial name
- DONE (NCT07322133)
- Testing
- Dopamine administration, Norepinephrine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Hypotension, Neonatal Hypotension
Appropriate Dosage of Vasopressor in Neonates and Infants
In this study, the investigators will evaluate cerebral blood flow before and after drug infusion using ultrasound to suggest blood pressure criteria and dosage of ephedrine, a vasopressor, to maintain adequate cerebral blood…
- Conditions
- Hypotension, Neonatal Hypotension, Intraoperative Complications
- Trial name
- NCT06257316
- Testing
- EPHEDrine Hydrochloride 5 mg/ml
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Fluid Therapy, Vasopressor Therapy
Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients
The goal of this woldwide observational study is to investigate various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients.
- Conditions
- Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation
- Trial name
- PRoFLUID (NCT05968066)
- Where
- Netherlands
- Volunteers
- 2,508 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)