Clinical trials: Vegetative State
Vegetative State, Minimally Conscious State
Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC
Previous studies showed that transcranial direct current stimulation (tDCS) transiently improves performance of motor function in stroke patients, as well as decrease muscle hypertonia.
- Conditions
- Vegetative State, Minimally Conscious State, Spasticity, Muscle, Disorder of Consciousness
- Trial name
- NCT03797573
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- University of Liege
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Vegetative State, Minimally Conscious State
Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State
Rationale. The investigators hypothesize that bilateral electrical central thalamic stimulation of patients in Vegetative State and Minimally Conscious State from at least 6 months could improve the level of responsiveness. Aims.
- Trial name
- CATS\ (NCT01027572)
- Testing
- Implantable neurostimulation system (Medtronic)
- Where
- 3 sites in Italy
- Volunteers
- 5 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acquired Brain Injury, Development, Child
COgnitive REhabilitation in Pediatric Patients with ABI, from Vegetative State to Functional Recovery
Acquired brain injuries (ABI) represent one of the most important cause of disability and mortality during the pediatric age, also in the western Countries.
- Trial name
- COREABI (NCT04499092)
- Testing
- Personalized Neuropsychological treatment (CORE-ABI), Sequential Neuropsychological treatment (SET-ABI)
- Where
- Italy
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Vegetative State, Minimally Conscious State
Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- NCT02626403
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University of Liege
Vegetative State
The Prognostic Value of Pupil Near Response in UWS Patients
Previous studies suggest that the stimulus of pupil near response (PNR) may be a conscious perception of a blurred image. Moreover, PNR is a reflex that can be objectively observed and with no motor output, suggesting it might be…
- Trial name
- NCT02832492
- Testing
- pupil near response
- Volunteers
- 20 people
- Sponsor
- Wentao Zeng
Vegetative State, Minimally Conscious State
Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal (DLPF) cortex transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- tDCS in DOC (NCT01673126)
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- University of Liege
Minimally Conscious State, Vegetative State
Validation of the Chinese Version of the SECONDs
The aim of this study was to translate the SECONDs from English into Chinese and determine the validity of this Chinese version
- Trial name
- NCT04687553
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hangzhou Normal University
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Vegetative State, Minimally Conscious State
Prefontal tDCS in Patients With Disorders of Consciousness: Neurophysiological and Behavioural Outcomes
Non-invasive brain stimulations techniques have recently shown promising results in patients with disorders. Notably, transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal cortex has proved…
- Conditions
- Vegetative State, Minimally Conscious State, Disorder of Consciousness
- Trial name
- NCT03823508
- Testing
- anodal tDCS
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University of Liege
Disorder of Consciousness, Minimally Conscious State
Spinal Cord Stimulation in Patients With Disorders of Consciousness
Disorders of consciousness(DOC) is the most serious complications and has been widely paid attention to by the government. DOC patients cause large social and economic burden to our society for there has no effective cure so far.
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT04010838
- Testing
- spinal cord stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huashan Hospital
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Disorders of Consciousness
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
The goal of this clinical trial is to test how effective the mindBEAGLE device is in allowing people who are unconscious (due to a brain injury or other condition) to communicate using brain waves to answer Yes/No questions.
- Trial name
- NCT06426602
- Testing
- mindBEAGLE daily device use
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy Wagner
Patients in Minimally Conscious State After a Severe Brain Injury (e.g., Anoxia, Traumatic Brain Injury, Stroke)
tDCS in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- tDCS in MCS (NCT02019615)
- Testing
- transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University of Liege
Persistent Vegetative State
18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness
Clinical examinations are difficult to discriminate between vegetative state and minimally conscious state. the diagnostic and prognostic usefulness of neuroimaging methods has not been established in a clinical setting.
- Trial name
- NCT02999490
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Disorder of Consciousness
Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction
Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs).
- Trial name
- CRS-R_Info (NCT05819177)
- Testing
- Rehabilitation program
- Where
- 2 sites in Spain
- Volunteers
- 171 people
- Sponsor
- Hospitales Nisa
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital