Clinical trials: Ventilation and Oxygenation
Anesthesia, General, Apnea
High Flow Nasal Cannula for Safe Apnea
This is a prospective randomized controlled trial comparing high flow nasal cannula and buccal oxygenation as method of oxygenation during apnea in children.
- Trial name
- NCT04849520
- Testing
- High flow nasal cannula, Buccal oxygenation
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Extremely Low Birth Weight Infants
Post-Extubation Assessment of Clinical Stability in ELBW Infants
This is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation…
- Trial name
- PEACE (NCT06037083)
- Testing
- Oxygen saturation probe, Near infrared spectroscopy sensors, Electrical impedance tomography
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sleep-disordered Breathing (SDB)
Sleep-disordered Breathing and Neurocognitive Assessment in Children and Young Adults
One of main problems in the management of sleep-disordered breathing (SDB) in children and young adults is their screening, and the absence or the weak correlation between clinical symptoms and polysomnography (PSG).
- Trial name
- TRSPed (NCT04971850)
- Testing
- Sleep study
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia
Venticute in Patients With Pneumonia or Aspiration of Gastric Contents and Intubation/Ventilation/Oxygenation Impairment (BY2001/M1-007)
Study to demonstrate that administration of Venticute increases survival of patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygenation impairment.
- Trial name
- NCT00074906
- Testing
- Venticute
- Where
- 92 sites in Australia, Austria and 15 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Prematurity, Respiratory Distress Syndrome
CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure
This study seeks to determine if standard continuous positive airway pressure, known as CPAP is as effective as a more complicated approach that generates intermittent increases in airway pressure applied to the nostrils via a…
- Conditions
- Prematurity, Respiratory Distress Syndrome, Apnea of Prematurity
- Trial name
- NICA (NCT03670732)
- Testing
- continuous positive airway pressure, nasal intermittent positive pressure ventilation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Lung Injury, Postoperative Complications
Ventilation During Cardiopulmonary Bypass
Postoperative pulmonary dysfunction (PPD) is a widely reported complication of cardiopulmonary bypass (CPB) although there is improvement in perioperative management, that leads to increased morbidity and mortality in cardiac…
- Conditions
- Lung Injury, Postoperative Complications, Pulmonary Collapse
- Trial name
- NCT04962542
- Testing
- ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Respiratory Distress Syndrome, Prematurity
The Effect of Surfactant Administration on Cerebral Oxygenation
The purpose of this study is to assess changes in cerebral oxygenation during two different types (beractant and poractant) and two different routes (double lumen or single lumen endotracheal tube) of surfactant administration…
- Trial name
- NCT01258517
- Testing
- near infrared spectroscopy (INVOS 5100)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Lung Surgery
Ventilation Strategies Impact on Oxygenation and Postoperative Pulmonary Complications in Lung Surgery Patients
The purpose of this clinical trial was to understand the effects of variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV)…
- Trial name
- NCT06805760
- Testing
- variable tidal volume ventilation (V-VCV), pressure-regulated volume-controlled ventilation (PRVC), conventional volume-controlled ventilation (C-VCV)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Inner Mongolia Baogang Hospital
Infratentorial Neoplasms, Hyperventilation
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
The aim of this study is to evaluate the changes of cerebral oxygen saturation during hyperventilation and normo-ventilation (using near-infrared spectroscopy) in pediatrics undergoing posterior fossa tumor resection.
- Conditions
- Infratentorial Neoplasms, Hyperventilation, Craniotomy
- Trial name
- NCT04232059
- Testing
- cerebral oximetry
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Heart Defects, Congenital, Respiratory Insufficiency
Study Using Citrate to Replace Heparin in Babies Requiring Extracorporeal Membrane Oxygenation (ECMO)
The purpose of this study is to determine the safety and efficacy of citrate to provide anticoagulation of an ECMO circuit without patient anticoagulation.
- Trial name
- NCT00968565
- Testing
- sodium citrate
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Vanderbilt University
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Anesthesia, General, Apnea
High-flow Nasal Oxygenation for Open Mouth
This study aims to evaluate the effect of high-flow nasal oxygenation on safe apnea time for children undergoing general anesthesia, with their mouth open.
- Trial name
- NCT04290728
- Testing
- Apnea with high-flow nasal cannula, Apnea
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Pediatric Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Prone Position During ECMO in Pediatric Patients With Severe ARDS
In 2023, the second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) updated the diagnostic and management guidelines for Pediatric Acute Respiratory Distress Syndrome (PARDS).
- Trial name
- PEPAD (NCT06369584)
- Testing
- prone position
- Where
- 8 sites in China
- Volunteers
- 7 people
- Sponsor
- Seventh Medical Center of PLA General Hospital
Respiratory Distress Syndrome, Adult, Respiratory Insufficiency
Australia and New Zealand Adult Extracorporeal Membrane Oxygenation (ECMO) Audit 2005
Extracorporeal membrane oxygenation (ECMO) is a means of artificially performing the function of the human lung and/or heart outside the body.
- Conditions
- Respiratory Distress Syndrome, Adult, Respiratory Insufficiency, Shock, Cardiogenic
- Trial name
- NCT00157144
- Where
- Australia
- Sponsor
- Bayside Health
One-Lung Ventilation, Thoracic Surgery
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups.
- Trial name
- NCT06505772
- Testing
- Dexmedetomidine, Normal saline
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus University
Infant,Premature
Oxygenation Instability and Maturation of Control of Breathing in Premature Infants
Premature infants present with significant oxygenation instability in the form of frequent spontaneous episodes of hypoxemia during the first weeks after birth. These infants are also exposed to hyperoxemia.
- Trial name
- NCT03445689
- Testing
- Assessment of oxygenation instability, Determination of mechanisms of hypoxemia episodes, Assessment of respiratory instability
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Neonatal Oxygen Desaturation, Premature
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's…
- Conditions
- Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
- Trial name
- NCT05968586
- Testing
- Body positioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center