Clinical trials: Ventilator-associated Conditions
Critical Illness, Sepsis
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients
Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher…
- Conditions
- Critical Illness, Sepsis, Septic Shock, Ventilator Associated Pneumonia
- Trial name
- SuDDICU (NCT02389036)
- Testing
- SDD Oral Paste, SDD Gastric Suspension, Intravenous Antibiotic
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 20,010 people
- Sponsor
- The George Institute
Pneumonia, Ventilator-Associated
Weekly Versus no Routine Ventilator Circuit Changes in NICU
The purpose of this study is to determine incidence of ventilator-associated pneumonia compared between weekly and no routine ventilator circuit changes in neonatal intensive care unit
- Trial name
- NCT02326207
- Testing
- Infant Ventilator Circuit Dual Heated with Autofeed Chamber
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Prince of Songkla University
COVID-19, Pneumonia, Viral
Artificial Intelligence Algorithms for Discriminating Between COVID-19 and Influenza Pneumonitis Using Chest X-Rays
This project aims to use artificial intelligence (image discrimination) algorithms, specifically convolutional neural networks (CNNs) for scanning chest radiographs in the emergency department (triage) in patients with suspected…
- Conditions
- COVID-19, Pneumonia, Viral, Influenza With Pneumonia, Flu Symptom
- Trial name
- AI-COVID-Xr (NCT04313946)
- Testing
- Scanning Chest X-rays and performing AI algorithms on images
- Where
- 3 sites in Italy, Romania and 1 more
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic
Ventilator Associated Pneumonia (VAP)
Pulmonary Infections and Barotrauma Associated With MV IN PICU
This study aims to determine the incidence, risk factors and outcome of ventilation associated common complication in the PICUs at Assiut University Children Hospital in Egypt.
- Trial name
- NCT05792501
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Pneumonia, Ventilator-Associated, Colistin Adverse Reaction
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates
This study is planned to compare the clinical efficacy and safety of aerosolized plus intravenous colistin vs. intravenous colistin as adjunctive therapy for the treatment of ventilator-associated pneumonia (VAP) due to…
- Conditions
- Pneumonia, Ventilator-Associated, Colistin Adverse Reaction, Infection Due to Multidrug Resistant Acinetobacter, Infection Resistant to Multiple Drugs
- Trial name
- NCT02806141
- Testing
- Aerosolized plus intravenous colistin, Intravenous colistin
- Where
- Thailand
- Volunteers
- 204 people
- Sponsor
- Hat Yai Medical Education Center
Ventilator Associated Pneumonia
How COVID-19 Virus Outbreak Affects Antimicrobial Resistance in a Low-middle-income Country's ICU?
A previous study showed a high incidence of ventilator-associated pneumonia to multidrug resistant pathogens in our ICU. That has been related to lack of compliance to hand hygiene among health care providers in ou ICU.
- Trial name
- NCT04348227
- Testing
- Enhanced hygiene measures
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
Enteral Feeding, Ventilator-Associated Pneumonia
Impact of Intermittent and Continuous Enteral Feeding on Ventilator-associated Pneumonia in Pediatric ICUs
Mechanical ventilation has become one of the most important supportive treatment methods to save the life of critically ill children over time.
- Trial name
- NCT02973347
- Testing
- Intermittent enteral feeding, Continuous enteral feeding
- Volunteers
- 400 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Infection, Enterocolitis, Necrotizing
Oropharyngeal Administration of Mother's Colostrum for Premature Infants (NS-72393-360)
Extremely premature (BW<1250g) infants are at high risk for morbidity and mortality. Own mother's colostrum (OMC) and milk (OMM) protect against neonatal morbidity and are rich in immune factors which may provide…
- Conditions
- Infection, Enterocolitis, Necrotizing, Ventilator-associated Pneumonia
- Trial name
- NCT02116699
- Testing
- oropharyngeal mother's milk, oropharyngeal sterile water
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Endeavor Health
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Care Bundle Prevention on Internship Students' Knowledge and Clinical Performance
The goal of this clinical trial is to determine the effect of a self-instructional module regarding ventilator-associated pneumonia care bundle prevention on internship students' knowledge and clinical performance in pediatric…
- Trial name
- NCT06090019
- Testing
- Routine PICU nursing care for children on mechanical ventilator., Self-instructional module for VAP care bundle prevention
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
CTTI Risk Factors for HABP/VABP Study
The purpose of this study is to better define the intensive care unit population at highest risk for developing Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (HABP/VABP).
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bacterial, Pneumonia, Hospital-Acquired
- Trial name
- PROPHETIC (NCT02689531)
- Where
- 15 sites in United States
- Volunteers
- 7,530 people
- Sponsor
- Duke University
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Ventilator Associated Pneumonia
Open Suction Circuit Flushing With Chlorhexidine Decreases Ventilator-Associated Pneumonia: A Quasi-experimental Study
Background: Standard practice of flushing saline over the patient's secretions following suctioning is similar to pouring water over grease, leading to motivating bacterial colonization and proliferation inside the suctioning…
- Trial name
- NCT05206721
- Testing
- Open tracheal suction system flushing with chlorhexidine
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Mansoura University
Ventilator-associated Pneumonia
Comparison of the Frequency of Ventilator-Associated Pneumonia in Intubated Patients Followed Up With Automatic Cuff Pressure Controller and Manual Cuff Pressure Controller in Pediatric Intensive Care
This study was designed to compare manual (intermittent) versus automatic (continuous) endotracheal cuff pressure monitoring for the prevention of ventilator-associated pneumonia (VAP) in mechanically ventilated pediatric…
- Trial name
- NCT05918172
- Testing
- endotracheal cuff pressure manual measurement, endotracheal cuff pressure automatic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Istanbul Medeniyet University
Ventilator Associated Pneumonia, Tracheobronchitis
A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship…
- Trial name
- BrighT STAR (NCT04987840)
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Ventilator Associated Pneumonia
Effect of Educational Program About Preventive Care Bundle for Prevention of Ventilator Associated Pneumonia Among Newborns
This study is designed to investigate the effect of educational program for nurses about preventive care bundle for prevention of ventilator associated pneumonia among newborns.
- Trial name
- NCT06066489
- Testing
- educational program about VAP
- Volunteers
- 137 people
- Sponsor
- Damanhour University
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Ventilation Acquired Pneumonia
Management of Ventilation Acquired Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center
The goal of this clinical trial is to determine the most effective empirical therapy of antibiotics for better ventilator-associated pneumonia control.
- Trial name
- NCT06739382
- Testing
- extended meropenem infusion in combination with other options such as Polymyxin, Tigecycline, Ertapenem, or Amikacin., two β-lactam antibiotics plus a single non-β-lactam antibiotic, Control group received standard therapy
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Beni-Suef University
Ventilator-Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) in Intensive Care Unit (ICU)
Ventilator-associated pneumonia (VAP) is very common in the intensive care unit (ICU), affecting 9 to 40% of ICU patients and mortality rates range from 20 to 50% and may reach more than 70% when the infection is caused by…
- Trial name
- NCT00935285
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Thessaly