Clinical trials: Ventilators
Preterm Birth, Bronchopulmonary Dysplasia
Improving Prematurity-Related Respiratory Outcomes at Vanderbilt
The goal of IMPROV is to identify molecular mechanisms that contribute to lung injury and long-term breathing problems in preterm infants by investigating two interrelated biochemical pathways: the urea cycle-nitric oxide pathway…
- Conditions
- Preterm Birth, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- IMPROV (NCT01460576)
- Where
- 2 sites in United States
- Volunteers
- 253 people
- Sponsor
- Vanderbilt University Medical Center
Ventilator Lung; Newborn
Influence of Respiratory Rate Settings on CO2 Levels During Nasal Intermittent Positive Pressure Ventilation (NIPPV).
Infants will be monitored by TcCO2 during three consecutive time periods of one hour each on a high and low rate of NIPPV, when in a stable condition.
- Trial name
- NCT04836689
- Testing
- nasal intermittent positive pressure ventilation (NIPPV).
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Bronchopulmonary Dysplasia
Fluid Filled Lung Oxygenation Assistance Trial
The primary study objective is to assess the safety and feasibility of perfluorooctylbromide (PFOB) partial liquid ventilation (PLV) in infants with severe Bronchopulmonary Dysplasia (BPD).
- Trial name
- FFLOAT (NCT03041740)
- Testing
- Perfluorooctyl Bromide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Bronchopulmonary Dysplasia
TINN2: Treat Infection in NeoNates 2
The aim of the TINN2 study is to evaluate the efficacy of azithromycin in prevention of bronchopulmonary dysplasia in preterm neonates.
- Trial name
- TINN2 (NCT02282176)
- Testing
- Azithromycin
- Where
- 16 sites in Belgium, France and 7 more
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Ventilator Lung, Surgery
Monitoring of Lung Ventilation Through Electrical Impedance Tomography During Pediatric Surgery
Given the scarcity of studies aimed at assessing the effect of anesthesia and m ventilation on the distribution of lung ventilation in pediatric patients undergoing surgery, with the exclusion of thoracic surgery, the present…
- Conditions
- Ventilator Lung, Surgery, Pediatric
- Trial name
- VentiPed (NCT06370507)
- Testing
- Electrical impedance tomography assessment of ventilation distribution in course of sedation/general anesthesia for pediatric surgery
- Volunteers
- 800 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Bronchopulmonary Dysplasia
Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants
To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.
- Trial name
- NCT04936477
- Testing
- Calculation of ventilation-perfusion ratio
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Prematurity, Respiratory Distress Syndrome
Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
The purpose of this study is to evaluate the hypothesis that nasal intermittent positive pressure(NIPP), used as a primary mode of ventilation in preterm infants with RDS, will decrease the need for conventional endotracheal…
- Trial name
- NCT00821119
- Testing
- nasal intermittent positive pressure ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Infant, Newborn, Infant, Low Birth Weight
Physiologic Definition of Bronchopulmonary Dysplasia
This observational study was conducted to design and test a physiologic definition for bronchopulmonary dysplasia at 36 weeks of life.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- PhysiologicDef (NCT01223287)
- Where
- 21 sites in United States
- Volunteers
- 410 people
- Sponsor
- NICHD Neonatal Research Network
Respiratory Diseases, Lung Diseases
In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation
Using an adult lung bench model of non invasive ventilation, the aim of the study is to compare an experimental system of breath-synchronized vibrating mesh nebulizer to a conventional vibrating mesh nebulizer during non invasive…
- Conditions
- Respiratory Diseases, Lung Diseases, Cystic Fibrosis, COPD
- Trial name
- Synchro-Neb (NCT02084043)
- Testing
- Nebulization of Amikacin during NIV (RR: 15 cycles/minute), Nebulization of Amikacin during NIV (RR: 25 cycles/minute)
- Where
- Belgium
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Bronchopulmonary Dysplasia
Mesenchymal Stem Cells for Prevention of Bronchopulmonary Dysplasia in Infants
The clinical study with UMC119-01 is designed to investigate the safety in patients with bronchopulmonary dysplasia ("BPD"). This will be a dose escalation, open-label, single-center study in infants at high risk for BPD.
- Trial name
- NCT03631420
- Testing
- Human Umbilical Cord Derived-Mesenchymal Stem Cells
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Meridigen Biotech Co., Ltd.
Premature, Tracheostomy Complication
Follow-up Results of Newborns With Tracheostomy
The chances of survival in premature babies, especially in babies born under 28 weeks, have increased in recent years, and comorbidities also increase.
- Conditions
- Premature, Tracheostomy Complication, Bronchopulmonary Dysplasia
- Trial name
- FRONWT (NCT04497740)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hacettepe University
Acute Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Invasive Ventilation Strategies for Neonates With Acute Respiratory Distress Syndrome Syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
- Conditions
- Acute Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, High Frequency Oscillation Ventilation
- Trial name
- NCT03372525
- Testing
- HFOV, CMV
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Systemic Inflammatory Response Syndrome, Ventilator Weaning
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient.
- Trial name
- NCT02820090
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital