Clinical trials: Volatile Organic Compound
Asthma, Cystic Fibrosis
Breath Analysis in Children by New Point-of-care Instruments
In this study new hand-held devices for measuring exhaled breath will be tested in children with asthma, CF, and healthy controls. Main objectives will be feasibility and discriminative value of these techniques.
- Trial name
- NCT03377686
- Testing
- inflammation markers in exhaled breath
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pulmonary Tuberculosis
Tuberculosis Volatile Organic Compounds
The Pulmonary Colonization Test is a non-invasive breath test for markers of lower respiratory tract infection, which may predict the probability of mycobacterial organisms in the lower respiratory tract.
- Trial name
- TBVOC (NCT01379066)
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
The Phenomenon of the Decrease in the Electrical Resistance Within the Conducting Chambers, Making the Increase in a Conducting Property
The Target Urine VOCs Biosensor for Genitourinary Malignancy Detection
Volatile organic compounds (VOCs) have grown due to their crucial role in transitioning from invasive to noninvasive cancer diagnostic methods.
- Trial name
- NCT06211010
- Testing
- the semiconductor metal oxide sensors.
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Suranaree University of Technology
Appendicitis Acute
Investigation of Oxidative Stress in Appendectomy - Open Versus Laparoscopic in Childhood and Adolescence
In the planned prospective randomized study, oxidative stress will be investigated by analyzing volatile organic compounds in the exhaled air in children.
- Trial name
- OSAE (NCT03723642)
- Testing
- Initial serum malondialdehyde level, Final serum malondialdehyde level, Initial differential white blood cell count
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Congenital Diaphragmatic Hernia
Microbiome and Volatile Organic Compounds in Patients With CDH
Despite improved prenatal diagnostics and therapeutic possibilities, congenital diaphragmatic hernia (CDH) represents a cross-disciplinary challenge.
- Trial name
- CDHVOCS (NCT03787160)
- Testing
- initial VOC, initial fecal microbiome, initial pulmonary microbiome
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Malaria
Diagnostic Utility of Volatile Organic Compounds in Human Breath for Acute Clinical Malaria in Ethiopia
This is a diagnostic efficacy study to evaluate a set of biomarkers in human breath indicative of an acute malaria infection. The investigators plan to enroll 75 malaria patients and 175 febrile non-malaria patients in Ethiopia.
- Trial name
- NCT02793414
- Sponsor
- Menzies School of Health Research
Cystic Fibrosis
Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF)
This study relies on the hypotheses that (1) exhaled breath is intimately correlated to the patient's lung condition and that (2)the composition of exhaled breath , i.e.
- Trial name
- VOLATIL-CF (NCT05726994)
- Testing
- exhaled breath collection, Data collection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Microbial Colonization, Neuroblastoma
Investigating the Microbiome and Volatile Organic Compound Profile of Children With Neuroblastoma
Background: Malignant tumors may lead to a catabolic state with loss of muscle and adipose tissue. The full picture of catabolism is termed cachexia and is associated with significant morbidity and mortality of cancer patients.
- Conditions
- Microbial Colonization, Neuroblastoma, Children, Only
- Trial name
- NCT03545542
- Testing
- Initial fecal microbiome, Initial fecal volatile organic compounds, Initial breath volatile organic compounds
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Diabetes, Hyperglycemia
Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia
- Trial name
- NCT06893341
- Testing
- The Sensing Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Asthma, Children
Reduction of Asthma Exacerbation Rate in Children by Non-invasive Monitoring of Inflammatory Markers in Exhaled Breath (Condensate): the RASTER Study
The purpose of the present proposal was to investigate the predictive properties of markers in exhaled breath to predict an asthma exacerbation.
- Conditions
- Asthma, Children, Home Monitoring, Exhaled Breath Condensate
- Trial name
- RASTER (NCT01239238)
- Where
- 2 sites in Netherlands
- Volunteers
- 102 people
- Sponsor
- Maastricht University Medical Center
Larynx Cancer
Breath Testing in Early and Late Larynx Cancer
It is possible to test a sample of breath from a patient, run it through a machine, and find out certain diseases in the patient without needing to do Xrays.
- Trial name
- NCT01700647
- Testing
- Breath test- sampling using ENose, Laryngoscopy and bronchoscopy
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Royal Brisbane and Women's Hospital
Diabetes, Hyperglycemia
Miniaturized Breath-based Sensor for the Detection of Hypo- and Hyperglycemia
The purpose of this study is to determine whether an array of biosensors can noninvasively identify hyperglycemic or hypoglycemic events in persons diagnosed with diabetes through noninvasive detection of volatile organic…
- Conditions
- Diabetes, Hyperglycemia, Hypoglycemia (Diabetic)
- Trial name
- NCT07696273
- Testing
- Sensing Device and Tedlar Bags
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Volatile Organic Compounds, Hypoglycemia
Biomarkers in Exhaled Breath of Glucose Fluctuation in Type 1 Diabetes
The investigators are investigating the "biochemical fingerprint" of hypoglycemia (low blood sugar) in the breath of people with type 1 diabetes.
- Conditions
- Volatile Organic Compounds, Hypoglycemia, Type 1 Diabetes Mellitus
- Trial name
- NCT03435198
- Testing
- Collect exhaled breath during low and normal blood sugar
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- East Tennessee State University
Malaria Fever
Non-invasive Malaria Diagnostic Data Collection in Ethiopia
This project supports the development of a non-invasive diagnostic tool for malaria, focusing on validating the link between VOCs (volatile organic compounds) and malaria infection using thermodynamic sensors.
- Trial name
- NCT07456969
- Where
- Ethiopia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Cystic Fibrosis, Pseudomonas Aeruginosa
Volatile Organic Compounds in Cystic Fibrosis
This experiment is designed to test the effectiveness of a new electronic nose device, which allows a non-invasive breath test for markers of lower respiratory tract infection, which may predict the probability of bacterial…
- Trial name
- VOCCF (NCT01379040)
- Testing
- Cystic Fibrosis patients
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Staphylococcus Aureus, Methicillin-resistant Staphylococcus Aureus
Volatile Organic Compounds in Staphylococcus Aureus Patients
The zNose® MRSA test is a non-invasive breath test for markers of Staphylococcus aureus, which may predict the probability of bacterial organisms in the anterior nares, throat and respiratory tract, wounds, and anus and therefore…
- Conditions
- Staphylococcus Aureus, Methicillin-resistant Staphylococcus Aureus, Nosocomial Disease
- Trial name
- MRSAVOC (NCT01379053)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
Volatile Organic Compounds, Radiography
Tuberculosis Screening in Paraguayan Prisons
Two diagnostic tools for TB screening in high risk groups need additional assessment: the AeoNose™, an 'electronic nose device' for breath sampling, and digital chest X-ray (CXR) with computer aided detection with CAD4TB®…
- Trial name
- Prinose (NCT04407325)
- Testing
- electronic nose device, dig chest Xray with automated readings
- Where
- 2 sites in Paraguay
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cystic Fibrosis, Children
Prevention of CF Exacerbation in Childhood: PREVEC Study
Pulmonary exacerbations of CF are an important cause for the experienced disability of patients, respiratory symptoms, and decreases in lungfunction, which require antibiotic therapy at home or in the hospital.
- Conditions
- Cystic Fibrosis, Children, Exhaled Breath Condensate, Non-invasive Inflammatory Markers
- Trial name
- PREVEC (NCT01241890)
- Where
- 3 sites in Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University Medical Center
Inflammatory Bowel Diseases
Evaluation of Faecal Volatile Organic Compounds in the Diagnosis of Paediatric Inflammatory Bowel Disease
Please see description below
- Trial name
- VOCs (NCT03170622)
- Testing
- Intervention group
- Where
- United Kingdom
- Volunteers
- 210 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust