Clinical trials: Volume Delivery
Respiratory Distress Syndrome
Effects of Volume Guarantee With Pressure Supported vs. Synchronized Intermittent Mandatory Ventilation in VLBW Infants
Studies in preterm infants have shown that adding volume guarantee (VG) to synchronized modes of ventilation is not only feasible but also advantageous for providing more constant and desirable mechanical breath size.
- Trial name
- NCT00295230
- Testing
- PSV+VG mode versus SIMV+VG mode
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Enteral Feeding
Does Volume-based Enteral Feeding Improve Nutrient Delivery in Hospitalized Critically Ill Children?
Background Some critically ill children have malnutrition which may worsen while they are in hospital and delay their return home. They can recover faster when they are given tube feedings to improve their nutrition.
- Trial name
- NCT05286177
- Testing
- Volume-based EN, Rate-based EN
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Respiratory Insufficiency
Pressure-limited Ventilation Versus Volume-targeted Ventilation in Term Newborns
A randomised controlled trial comparing volume-targeted ventilation to pressure-limited ventilation in infants born at or near term.
- Trial name
- NCT02358460
- Testing
- Ventilation delivered by SLE5000 ventilator
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Respiratory Distress Syndrome, Newborn, Respiratory Failure
Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Failure, Premature Birth
- Trial name
- NCT04391634
- Testing
- volume guarantee, pressure-controlled
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Poznan University of Medical Sciences
Prematurity
Milk And Growth In Children (MAGIC) Born Very Preterm: A Randomized Trial
The goal of this multi-center randomized, parallel group trial is to determine the effect of human milk diets ranging between 180 and 200 mL/kg/day on the body composition outcomes of moderately preterm infants born between 27…
- Trial name
- MAGIC (NCT06420531)
- Testing
- Human milk
- Where
- 4 sites in United States
- Volunteers
- 486 people
- Sponsor
- University of Alabama at Birmingham
Necrotizing Enterocolitis, Sepsis
Probiotic Administartion to Mothers of Preterm Infants to Prevent Necrotizing Enterocolitis and Sepsis
We hypothesize that supplementing maternal diet with probiotics will decrease the incidence of feeding intolerance, necrotizing enterocolitis and sepsis in preterm infants fed breastmilk.
- Trial name
- NCT00835874
- Testing
- Probiotics
- Where
- Israel
- Volunteers
- 57 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Resuscitation
Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen
QUESTION: Is controlled tidal volume delivery during the resuscitation of preterm infants < 28 weeks' gestation safe and feasible? BACKGROUND AND RATIONALE: Current resuscitation of preterm neonates follows the Neonatal…
- Trial name
- NCT00157989
- Testing
- Controlled tidal volume resuscitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mount Sinai Hospital, Canada
Postnatal Growth Restriction
Impact of Hindmilk on Weight Gain Among Moderate to Very Preterm Infants in Zambia
The primary hypothesis is that very preterm infants between 28 0/7 to 31 6/7 weeks with a birth weight from 1000-1999 grams allocated to the HV breastmilk group (200-240 mL/kg/day) until hospital discharge or 40 weeks'…
- Trial name
- NCT05403684
- Testing
- High-volume breastmilk
- Where
- Zambia
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Intrauterine Growth Retardation (IUGR), Lung Function Tests
Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.
During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound.
- Conditions
- Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring
- Trial name
- ELFIGO (NCT06919757)
- Testing
- fetal ultrasound to assess lungs, heart and diaphragm
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Placental Transfusion
Placental Transfusion and Cord Clamping
To compare the evolution of the infant's weight before delayed cord clamping (2 minutes after birth) as an indirect measure of the volume of placental transfusion in a group of healthy and fullterm newborns, placed at the level…
- Trial name
- NCT01497353
- Testing
- Position at introitus level, position at Maternal Abdomen
- Where
- 3 sites in Argentina
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Salud Materno Infantil
Thyroid, Gland; Functional Disturbance
Ultrasound and Functional Thyroid Evaluation
Thyroid disorders are most commonly concomitant with prematurity and still remains a controversial topic. The incidence of a temporary form of hypothyroidism among preterm neonates is higher than in the general population.
- Trial name
- NCT04208503
- Testing
- thyroid ultrasound
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Apnea of Prematurity, Intermittent Hypoxia
Pilot Study to Evaluate Doses of Mechanical Stimulus on the Effectiveness of Preterm Breathing
The goal of this clinical trial is to compare, in healthy preterm babies, 9 doses of dorsal mechanical stimuli, in order to answer: if there is a dose of dorsal mechanical stimuli that improves the basal respiration.
- Trial name
- NCT06639581
- Testing
- 20 per minute stimulus, 30 per minute stimulus, 40 per minute stimulus
- Where
- Chile
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Pregnancy, Cesarean Delivery
Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia
Transthoracic echocardiography (TTE) has been introduced in anesthesia and intensive care practice to assess the volume status and predict fluid responsiveness, with a few studies performed on pregnant women (5).
- Conditions
- Pregnancy, Cesarean Delivery, Spinal Anesthesia Induced Hypotension, Cardiac Output Measurement
- Trial name
- NCT06654687
- Testing
- Transthoracic Echocardiography, Ringer lactate 1000 ml, Albumin
- Where
- Egypt
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Sameh Fathy
Extra Uterine Growth Restriction, Premature Infant Disease
Does Starting Feeds on the First Day of Life Help Premature Infants Reach Full Volume Feeds Sooner?
Feeding advancements in ELBW infants have evolved over decades. The fear of causing mortality and morbidity, notably NEC, have made providers cautious when advancing feeds.
- Conditions
- Extra Uterine Growth Restriction, Premature Infant Disease, VLBW - Very Low Birth Weight Infant
- Trial name
- NCT06731439
- Testing
- Starting feeds within 6 hours of life, Standard feeding protocol
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- University of Tennessee
Neonatal Respiratory Failure
Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns
Aims: There is increasing evidence that volume-targeted ventilation (VTV) holds benefits for preterm infants in comparison to pressure-limited ventilation. This study aims to compare pressure-limited to VTV in preterm infants.
- Trial name
- NCT01531010
- Testing
- Ventilation protocol delivered by the SLE5000 ventilator
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Oxygen Saturation Targetting in Preterm Ventilated Infants
Comparison of Automated Oxygen Control With and Without Automated Pressure Control in Preterm Ventilated Infants.
This is a cross-over randomized study. Eligible participants are preterm infants born at less than 37 weeks gestation (23+0 to 36+6 weeks), who are receiving conventional mechanical ventilation through an endotracheal tube and…
- Trial name
- CLIO-VG (NCT03865069)
- Testing
- Mode of ventilation (Volume Guarantee)®, Mode of ventilation (Volume control Ventilation)
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Thrombocytopenia, Transfusion
Study Comparing Platelet Transfusion Volumes in Premature Babies
Platelet transfusions can help clotting but may also have risks. Currently when babies get platelet transfusions they get as much as three times (per kilogram of body weight) as much as adults do.
- Trial name
- PlaNeT-3 (NCT06095648)
- Testing
- Dose of platelet transfusion
- Where
- Ireland
- Volunteers
- 370 people
- Sponsor
- University College Dublin
Infant, Premature
Brain Volumes of Very Low Birth Weight Infants Measured by Cranial Ultrasonography
Neonatal cranial ultrasound (US) remains the method of choice to detect brain injury in high risk preterm infants on neonatal intensive care units (NICU).
- Trial name
- NCT02848755
- Testing
- Cranial ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 341 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Premature Birth, Electrical Impedance Tomography (EIT)
Lung Volume Changes in Stable Preterm Infants Positioned in Car Seats
Premature infants (infants born <37 weeks' gestational age) are discharged from the hospital and transported home in car seats designed for term babies. The safe transport of these premature infants is an important concern.
- Conditions
- Premature Birth, Electrical Impedance Tomography (EIT), Lung Volume, Car Seat Transition for At-risk Infants
- Trial name
- CarSeat (NCT06724601)
- Testing
- Electrical Impedance Tomography
- Where
- Switzerland
- Volunteers
- 51 people
- Sponsor
- University of Zurich
Prematurity, BPD - Bronchopulmonary Dysplasia
Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room
Despite significant improvement in preterm infant survival, the incidence of bronchopulmonary dysplasia (BPD) in infants born < 28 weeks gestational age (GA) has been relatively stable at ~40%, with 10,000-15,000 new cases…
- Conditions
- Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT03938532
- Testing
- Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baystate Medical Center