Clinical trials: Warfarin
Hematoma
Bridge or Continue Coumadin for Device Surgery Randomized Controlled Trial
Many cardiac patients requiring device (defibrillator or pacemaker) related surgery are on chronic oral anticoagulation therapy (usually coumadin).
- Trial name
- BRUISECONTROL (NCT00800137)
- Testing
- low molecular weight heparin or unfractionated heparin, Warfarin or coumadin
- Where
- 22 sites in Brazil, Canada
- Volunteers
- 984 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation
Following Patients on Warfarin Therapy to See if Differences in Hemorrhagic Complications Exist
This is a prospective observational cohort study that is in the process of enrolling and following patients on warfarin therapy by utilizing anticoagulation clinics in VA hospitals across the US.
- Trial name
- NCT00075985
- Where
- 17 sites in United States
- Volunteers
- 700 people
- Sponsor
- US Department of Veterans Affairs
Anticoagulation
Excessive Warfarin Anticoagulation - Causes and Consequences
The aim of this study is to investigate the clinical significance of high INR (International Normalized Ratio) values (>9) in VKA (vitamin K antagonist) treated patients with atrial fibrillation.
- Trial name
- EWA (NCT02761941)
- Where
- Finland
- Volunteers
- 25,000 people
- Sponsor
- University of Turku
Congenital Heart Defects
Model-based Versus Traditional Warfarin Dosing in Children
This study compares the clinical effectiveness of a new algorithm (model-based warfarin dosing) with standard practice (doctor's own judgement and intuition) designed to determine the most appropriate anticoagulant dose of…
- Trial name
- WATCH (NCT02475863)
- Testing
- Warfarin Dosing Aid, Standard Practice
- Volunteers
- 45 people
- Sponsor
- De Montfort University
Cerebral Vein Thrombosis
Rivaroxaban vs. Warfarin in CVT Treatment
Cerebral venous thrombosis (CVT) is an uncommon venous-type of stroke tends to affect younger patients with somewhat different risk factors and much better outcome compared to arterial strokes.
- Trial name
- RWCVT (NCT04569279)
- Testing
- Rivaroxaban, Warfarin
- Where
- Syria
- Volunteers
- 71 people
- Sponsor
- Damascus University
Blood Coagulation Disorder
Comparison Between Point of Care Device and Venous Blood International Normalized Ratio Measurements.
Investigate the validity of Hemosense System in pediatric patients on anticoagulation therapy.
- Trial name
- NCT00288808
- Testing
- Hemosense (PT/InR point of care device)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Rochester
Elevated Lipoprotein(a), Cardiovascular Diseases
Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin
This is a single center, open label, single sequence, two-treatment, two-period drug-drug interaction study to evaluate the effect of multiple doses of ISIS 681257 on the pharmacokinetics of a single dose of warfarin.
- Trial name
- NCT03426033
- Testing
- ISIS 681257, Warfarin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akcea Therapeutics
Health Literacy, Anticoagulation
Electronic KIDCLOT Interactive Thrombosis/Thrombophilia Education; A Quality Assurance Initiative
Effective patient education improves health literacy and engagement thus improving long-term health outcomes. Health literacy is imperative to make informed health decisions and relies on the ability to obtain, process and…
- Trial name
- eKITE (NCT03910933)
- Testing
- elearning patient information
- Where
- 6 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Craniocerebral Trauma, Head Injuries, Closed
The AHEAD Study: Monitoring Anticoagulated Patients Who Suffer Head Injury
Existing practice in emergency departments (ED) in the United Kingdom (UK) for managing patients taking warfarin after a blunt head injury is variable with little research that supports the most appropriate way to manage these…
- Trial name
- NCT02461498
- Volunteers
- 3,556 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Thromboembolism
Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
RATIONALE: Warfarin may be effective in preventing the formation of blood clots in patients with central venous catheters. PURPOSE: Randomized clinical trial to study the effectiveness of warfarin in preventing blood clots in…
- Trial name
- NCT00024297
- Testing
- warfarin
- Where
- 38 sites in United Kingdom
- Sponsor
- Cancer Research Campaign Clinical Trials Centre
Atrial Fibrillation
Length of Stay in NVAF Patients Hospitalized and Initiated With Dabigatran or Warfarin in Japan
The primary objective of this study is to compare the Length of Stay from treatment of oral anticoagulant initiation to hospital discharge of patients hospitalized and subsequently treated with dabigatran or warfarin for…
- Trial name
- NCT02631057
- Testing
- Dabigatran, Warfarin
- Where
- 2 sites in Japan
- Volunteers
- 4,313 people
- Sponsor
- Boehringer Ingelheim
Quality of Life
Patient-Centred Care for Warfarin Management: A Pilot Study to Transition Care to High Risk Patients
Warfarin remains the only oral anticoagulant effective in preventing stroke and valve thrombi for patients having mechanical heart valves (MHVs).
- Trial name
- NCT03295799
- Testing
- Patient Self-Management
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- University of Alberta
Prescribers' Drug Orders
Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin
To determine if a computerized stop order will reduce the number of concurrent trimethoprim/sulfamethoxazole and warfarin orders accepted through the inpatient electronic ordering system while a patient is hospitalized.
- Trial name
- warf-tmp/smx (NCT00870298)
- Testing
- Trimethoprim/Sulfamethoxazole and Warfarin
- Volunteers
- 1,971 people
- Sponsor
- University of Pennsylvania
Warfarin
Patient Self Testing of Warfarin Therapy
To test the hypothesis that home international normalised ratio (INR) monitoring with supervised patient self-testing (PST)can provide comparable or superior time in therapeutic range (TTR) to that provided by traditional…
- Trial name
- NCT00594828
- Testing
- CoaguChek (Patient self testing), Anticoagulation Management Service (AMS)
- Where
- Ireland
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University College Cork
Congenital Heart Disease, Congenital Heart Defect
Comparison of Home and Standard Clinic Monitoring of INR in Patients With CHD
Summary: Congenital heart disease (CHD) is the most prevalent form of birth defect with a global rate of 1.35 million newborns born with CHD annually.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Adult Congenital Heart Disease
- Trial name
- NCT04136379
- Testing
- INR monitoring using a CoaguChek POC device
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Ulster
Warfarin
Warfarin Dosage Adjustment Model Analysis Study
Despite the wide availability of Direct oral anticoagulation (DOAC), warfarin remains an important oral anticoagulant1 especially in patients with mechanical valve replacement or chronic renal failure where the evidence of DOAC…
- Trial name
- NCT05609500
- Testing
- Warfarin dosage adjustment model
- Where
- Hong Kong
- Volunteers
- 1,200 people
- Sponsor
- Chinese University of Hong Kong
Embolism, Thrombophlebitis
Treatment for Blood Clots in the Veins of the Legs
Acute deep venous thrombosis (ADVT) of the lower extremity is a common disorder. Traditional treatment with anticoagulation therapy is effective in reducing the associated risk of pulmonary embolism, but is ineffective in…
- Trial name
- NCT00001713
- Testing
- Recombinant Tissue Plasminogen Activator, Heparin, Warfarin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Adverse Drug Events (ADEs)
Enhancing the Safety of Warfarin in Nursing Homes
Oral anticoagulant therapy with warfarin is essential for the prevention of strokes and other thromboembolic events related to various medical conditions; however, use of this therapy can be associated with an increased risk of…
- Trial name
- NCT00682773
- Testing
- SBAR
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Atrial Fibrillation, Stroke
Quality of Anticoagulation With Warfarin in Patient With Atrial Fibrillation for Secondary Stroke Prevention in Korea
The current study aims to assess the quality of anticoagulation with warfarin in real world practice of secondary stroke prevention in Korean patients with Atrial fibrillation (AF) and to explore predictors for poor International…
- Trial name
- NCT02810509
- Where
- 18 sites in South Korea
- Volunteers
- 1,814 people
- Sponsor
- Inje University
Atrial Fibrillation
Warfarin - How Good Are we at Maintaining Target Range ?
Patients with atrial fibrillation are often anticoagulated with Warfarin. Warfarin has a narrow therapeutic window requiring frequent monitoring.
- Trial name
- NCT01081327
- Where
- United Kingdom
- Volunteers
- 5,000 people
- Sponsor
- University of Dundee