Clinical trials: Weaning Failure
Distress Respiratory Syndrome, Weaning Failure
Pressure Support Ventilation Versus Neurally Adjusted Ventilatory Assist in Difficult to Wean Pediatric Patients
This study assessed the effects of NAVA versus Pressure Support Ventilation (PSV) on patient-ventilator interaction in pediatric patients with difficult weaning from mechanical ventilation after moderate Pediatric Acute…
- Trial name
- NCT04360590
- Testing
- pressure support ventilation versus neurally adjusted ventilatory assist
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Weaning Failure
Utility of a Weaning Protocol in ICU
The purpose of this study is to evaluate the difference of the duration of weaning process from the ventilator between protocol-driven weaned patients and clinical judgment driven weaned patients.
- Trial name
- WEAN (NCT01877850)
- Testing
- weaning protocol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ELENA PELI,MD
Neonatal Respiratory Failure
Trial of Weaning by Synchronized Ventilation
During assist control ventilation and pressure support ventilation (PSV), the start of ventilator inflation is determined by the start of the infant's inspiratory effort.
- Trial name
- NCT01376544
- Testing
- Treatment protocol designed to evaluate (SLE 5000 ventilator)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College London
Preterm Infants
Weaning Preterm Infants at 1500 Grams From Incubators
Background: The weight at which infants are weaned from incubators varies among neonatal units. Objective: To determine the effect on weight gain, temperature stability and resting energy expenditure (REE) of weaning infants at…
- Trial name
- NCT01083303
- Testing
- Weaning Preterm Infants from an incubator
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Weaning Failure
Preventing Celiac Disease by Weaning With Mediterranean Diet
Background: The introduction of solid foods in alignment with the Mediterranean Diet (MD) post-exclusive milk feeding has been demonstrated to cultivate a lasting affinity for healthy eating during infancy and childhood.
- Trial name
- PEMED (NCT06184906)
- Testing
- Weaning by Mediterranean Diet
- Volunteers
- 3,200 people
- Sponsor
- University of Naples
Neonatal Respiratory Failure
Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange.
- Trial name
- Flow&Grow (NCT06123143)
- Testing
- Standardized/structured CPAP weaning protocol
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of California, San Diego
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
WorldwidE AssessmeNt of Separation of pAtients From Ventilatory assistancE
WEAN SAFE (WorldwidE AssessmeNt of Separation of pAtients From ventilatory assistancE) is a multi-centre, prospective, observational, 4-week inception cohort study being carried out by the Acute Respiratory Failure section of…
- Trial name
- WEAN SAFE (NCT03255109)
- Where
- Belgium
- Volunteers
- 11,000 people
- Sponsor
- European Society of Intensive Care Medicine
Weaning Failure
Negative Pressure Ventilation in Paediatric Patients During Weaning
Negative pressure ventilation (NPV) represent a unique form of noninvasive ventilation using negative pressure by specialized cuirass, that evolve negative pressure on the front size of chest and partially abdomen and facilitate…
- Trial name
- NEGWEAN (NCT05035290)
- Testing
- Negative pressure ventilation
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Brno University Hospital
Respiratory Failure
Study to Improve Treatments and Follow-up of Children Who Need Respiratory Support
Mechanical ventilation is a vital therapeutic support, widely used in pediatric intensive care. Invasive ventilation (IV) is associated with risk of major complications ( nosocomial pneumonia, secondary pulmonary barotrauma…
- Trial name
- Edi-PTP (NCT02154542)
- Testing
- Neurovent Monitor XIII
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Respiratory Failure
Weaning Children From Mechanical Ventilation:Computer-driven System Versus Usual Care
The purpose of this study is to determine whether a computer-driven system (Smartcare/PS) decreases weaning duration from mechanical ventilation when compared to usual care in children.
- Trial name
- NCT00678912
- Testing
- Smartcare/PS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Failure to Wean, Respiratory Failure
Inspiratory Muscle Training in Ventilator Dependent Patients
The purpose of this study is to determine if inspiratory muscle strength training will increase the proportion of ventilator dependent patients weaned versus Sham treated patients.
- Conditions
- Failure to Wean, Respiratory Failure, Ventilator Dependent
- Trial name
- NCT00419458
- Testing
- inspiratory muscle strength training
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Brain Injury
Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.
Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.
- Trial name
- GODWEAN (NCT02235376)
- Testing
- weaning trial of mechanical ventilation
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
ICU Acquired Weakness, Weaning Failure
Predictors of Prognosis in Patients With Critical Illness.
Recently, intensive care unit acquired weakness (ICUAW) has become a hotspot issue in the patients with critical illness. The symptoms of ICUAW, including sensory impairment and muscle atrophy, may lead to poor quality of life…
- Conditions
- ICU Acquired Weakness, Weaning Failure, Quality of Life
- Trial name
- NCT04914065
- Testing
- Regular care in the surgery intensive care unit
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taoyuan General Hospital
Intestinal Failure, Parenteral Nutrition
Weaning is Winning? (WeWin Study)
We propose a multicenter prospective study on pediatric patients with intestinal failure (IF) who weaned off parenteral nutrition (PN).
- Trial name
- NCT06525753
- Testing
- Weaning off Parenteral Nutrition
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- The Hospital for Sick Children
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help pediatric patients who have experienced heart failure during surgery and cannot be removed from cardiac…
- Trial name
- NCT01171950
- Testing
- CentriMag Ventricular Assist System
- Sponsor
- Abbott Medical Devices
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Bronchiolitis, Respiratory Failure (Pediatric Patients)
Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Intensive Care Unit
Bronchiolitis is a leading cause of pediatric hospital admissions. Despite its limited clinical benefits, the use of HFNC in children with bronchiolitis is increasing.
- Conditions
- Bronchiolitis, Respiratory Failure (Pediatric Patients), High Flow Nasal Cannula
- Trial name
- NCT06621641
- Testing
- The new HFNC weaning protocol
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr. Behcet Uz Children's Hospital