Clinical trials: Weaning of Mechanical Ventilation
Mechanical Ventilation, Sedation
Sedation and Ventilator Weaning Protocol in PICU
This research is a single-blinded, randomized controlled trial involving mechanically ventilated children in Pediatric Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia.
- Trial name
- NCT04788589
- Testing
- Sedation and ventilator weaning protocol
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Prone Position, Supine Position
The Effect of the Position Given to the Child After Weaning from Noninvasive Mechanical Ventilation on Physiological Symptoms
The aim of this clinical trial was to investigate the effect of the position given to children after weaning from noninvasive mechanical ventilation on the physiological symptoms (heart rate, oxygen saturation, respiratory rate…
- Conditions
- Prone Position, Supine Position, Child
- Trial name
- NCT06580522
- Testing
- Prone Position Group, Supine Position Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Acibadem University
Weaning From Mechanical Ventilation in Care Unit
Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach
Context: Several authors have been interested in applying Artificial Intelligence (AI) to medicine, using various Machine Learning (ML) techniques: managing septic shock, predicting renal failure...
- Trial name
- NCT05886803
- Testing
- Spontaneous ventilation test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Respiratory Insufficiency
Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population
Integrated pulmonary index (IPI) is a tool that monitors respiratory status. It takes into account four parameters: respiratory rate, end-tidal CO2, heart rate and O2 saturation using a pulse oximeter and specialized sidestream…
- Trial name
- IPI (NCT01795196)
- Where
- United States
- Sponsor
- Rush University Medical Center
High Velocity Nasal Insufflation, Simple Oxygen
A Randomized Clinical Trial for Predictors of Successful Extubation of Pediatric Patients With or Without High Velocity Nasal Insufflation
A randomized clinical trial about predictors of successful extubation of pediatric patients from mechanical ventilation either on High Velocity Nasal Insufflation or simple nasal oxygen and comparing the outcome
- Conditions
- High Velocity Nasal Insufflation, Simple Oxygen, Weaning Criteria
- Trial name
- NCT07383051
- Testing
- Comparing the outcome of pediatric patients after successful weaning on either High Velocity Nasal Insufflation or simple oxygen, comparing High Velocity Nasal Insufflation to simple oxygen after successful weaning of pediatric patients
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Respiratory Mechanics, Monitoring, Physiologic
Dynamic Non-invasive Monitoring of Inspiratory Effort
This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation.
- Conditions
- Respiratory Mechanics, Monitoring, Physiologic, Respiratory Insufficiency Requiring Mechanical Ventilation, Critical Illness
- Trial name
- NCT07839949
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Pediatric Liver Transplantation, Weaning From Mechanical Ventilation
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing…
- Trial name
- NAVIGATE (NCT04792788)
- Testing
- Weaning from mechanical ventilation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Respiratory Failure
Study to Improve Treatments and Follow-up of Children Who Need Respiratory Support
Mechanical ventilation is a vital therapeutic support, widely used in pediatric intensive care. Invasive ventilation (IV) is associated with risk of major complications ( nosocomial pneumonia, secondary pulmonary barotrauma…
- Trial name
- Edi-PTP (NCT02154542)
- Testing
- Neurovent Monitor XIII
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Mechanical Ventilation Weaning Phase in Children
Safety and Feasibility Study of a Mechanical Ventilation Computerized Protocol: Intellivent
The present protocol will demonstrate the safety, feasibility and efficacy of a newly computerized protocol integrated into a ventilator: S1 ventilator (Hamilton Medical).
- Trial name
- CloserPed (NCT01095406)
- Testing
- S1 ventilation
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Ventilators, Mechanical, Work of Breathing
Effort of Breathing Guided Ventilator Protocol
This pilot study tests the feasibility of using a computerized ventilator management protocol seeking to encourage lung protective ventilation during the acute phase of ventilation, and esophageal manometry based titration of…
- Trial name
- EOBvent (NCT02989246)
- Testing
- Ventilator protocol, Esophageal Catheter
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Los Angeles
Mechanical Ventilation
Work of Breathing Assessment During Weaning From Mechanical Ventilation
Introduction In patients assisted by mechanical ventilation, the Work Of Breathing (WOB) is shared between the patient and the ventilator.
- Trial name
- WOAW (NCT02762292)
- Testing
- Measurement of work of breathing using indirect calorimeter
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Mechanical Ventilation
The Ratio of Diaphragmatic Movement Between the Midaxillary Line and the Midclavicular Line Predicts the Success Rate of Weaning From Mechanical Ventilation
This study will provide individualized objective indicators for patients undergoing invasive mechanical ventilation. It will set specific assessment parameters for weaning and extubation for different patients, increase the…
- Trial name
- NCT07235956
- Testing
- Observe the ratio of diaphragmatic excursion between the midaxillary line and the midclavicular line in the successful group of invasive mechanical ventilation weaning.
- Volunteers
- 100 people
- Sponsor
- Zheng Qingjiang
Intensive Care Medicine, Mechanical Ventilation
The Classification of Difficult Weaning and the Predictive Value of Relative Factors for Difficult Weaning
To evaluate the distribution of different types of difficult weaning and the predictive value of weaning relative factors.
- Conditions
- Intensive Care Medicine, Mechanical Ventilation, Weaning
- Trial name
- NCT02487927
- Testing
- weaning
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jianfeng Xie
Critically Ill
Frequency of Screening and SBT Technique Trial
The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Trial name
- FAST (NCT02399267)
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Brain Injury
Criteria of Extubation Failure of Brain Injured Patients. Elaboration of a Prognostic Score.
Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.
- Trial name
- GODWEAN (NCT02235376)
- Testing
- weaning trial of mechanical ventilation
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critically Ill
The Frequency of Screening and SBT Technique Trial: The FAST Trial
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing.
- Trial name
- NCT02969226
- Testing
- Once daily screening, Twice daily screening, PS SBTs
- Where
- 17 sites in United States, Canada
- Volunteers
- 760 people
- Sponsor
- Unity Health Toronto
Ventilator Weaning
Home-based Optimization of Mechanical Ventilation in Children
Some children who are born very early or have other congenital conditions may develop severe, long-term lung problems that make them need to use a breathing machine to live at home.
- Trial name
- HOMVent4Kids (NCT06055413)
- Testing
- Remote patient monitoring (RPM) bundle
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago