Clinical trials: Whipworm
Trichuriasis
Efficacy and Safety of IVM/ALB Co-administration
This study is a double-blind randomized clinical trial conducted with two settings in Africa and one in Asia, namely Côte d'Ivoire, Pemba (Zanzibar, Tanzania) and Lao PDR.
- Trial name
- NCT03527732
- Testing
- Albendazole, Albendazole and Ivermectin
- Where
- 3 sites in Côte d’Ivoire, Laos and 1 more
- Volunteers
- 1,673 people
- Sponsor
- Jennifer Keiser
Trichuris Infection, Helminthiasis
Albendazole Plus High Dose Ivermectin for Trichuriasis in Pediatric Patients
There are four species of intestinal worms collectively known as soil-transmitted helminthiasis (STH): Ancylostoma duodenale and Necator americanus (hookworms), Ascaris lumbricoides (roundworms), and Trichuris trichiura…
- Trial name
- HI4T (NCT04041453)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in Argentina, Honduras
- Volunteers
- 176 people
- Sponsor
- Alejandro Krolewiecki
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Pemba (NCT06736691)
- Testing
- emodepside (BAY 44-4400), Mebendazole
- Where
- Tanzania
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Parasitic Diseases
Safety and Efficacy of Drug Combinations Against Trichuris Trichiura
This randomised, controlled, double-blinded clinical study investigates the safety and efficacy of albendazole (ALB), mebendazole (MBD) and ivermectin (IVM) separately, and ALB and MBD each in combination with IVM in the…
- Trial name
- NCT01050452
- Testing
- albendazole, mebendazole, ivermectin
- Where
- Uganda
- Volunteers
- 750 people
- Sponsor
- DBL -Institute for Health Research and Development
Trichuris Trichiura; Infection
Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura
The study rationale is to provide evidence on effective doses of moxidectin and/or moxidectin-albendazole in adolescents (16-18 years old) infected with Trichuris trichiura. The study will take place on Pemba Island, Tanzania.
- Trial name
- MOXIDOSE (NCT03501251)
- Testing
- Moxidectin 8mg, Moxidectin 8 mg + albendazole 400 mg, Moxidectin 16 mg
- Where
- Tanzania
- Volunteers
- 286 people
- Sponsor
- Swiss Tropical & Public Health Institute
Trichuriasis, Ascariasis
Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to albendazole monotherapy in school-aged…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Moxiped (NCT06188715)
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 224 people
- Sponsor
- Jennifer Keiser
Diarrhoeal Disease, Hookworm Infection
Evaluating Impact of Improved Floors on Health
The goal of this intervention study is to learn about the impact of household flooring on health in rural Kenya, and test whether providing an improved (cement stabilised, washable) floor improves the health of children and their…
- Conditions
- Diarrhoeal Disease, Hookworm Infection, Ascaris Lumbricoides Infection, Trichuris Infection
- Trial name
- SABABU (NCT05914363)
- Testing
- Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming
- Where
- Kenya
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Trichuris Infection
Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita
The purpose of this clinical trial is to compare the efficacy and safety of emodepside with the standard treatment, albendazole, in adolescents (12 years and older) and adults infected with Trichuris incognita.
- Trial name
- EMOTI (NCT07258173)
- Testing
- Emodepside, Albendazole 400 mg
- Volunteers
- 100 people
- Sponsor
- Jennifer Keiser
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura
This study aims to provide evidence on the efficacy, safety and acceptability of the new, chewable formulation of oxantel pamoate administered as a single dose or multiple doses, compared to mebendazole in children infected with…
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- OXA-TRI (NCT06720259)
- Testing
- Oxantel Pamoate, Mebendazole
- Where
- Tanzania
- Volunteers
- 163 people
- Sponsor
- Jennifer Keiser
Helminthes; Infestation, Intestinal
Evaluation of Effectiveness of ALBENDAZOLIVERMECTIN Coformulation vs ALBENDAZOLE for Treatment of Intestinal Worms
The purpose of this clinical trial is to evaluate a fixed-dose co-formulation (FDC) of ivermectin and albendazole for the treatment of all Soil Transmitted helminths (STH).
- Trial name
- ALIVE (NCT05124691)
- Testing
- Albendazole and Ivermectin fixed dose coformulation, Albendazole
- Where
- 3 sites in Ethiopia, Kenya and 1 more
- Volunteers
- 1,001 people
- Sponsor
- Barcelona Institute for Global Health
Helminthiasis
Relative Efficacy of Two Regimens of Ante-helminthic Treatment
The most common soil transmitted helminthic infections(STHI) includes infection with Ascaris lumbricoides, Trichuris trichiura, and Hookworm.
- Trial name
- NCT00367627
- Testing
- Albendazole
- Where
- Bangladesh
- Volunteers
- 200 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Trichuriasis, Hookworm Infections
Albendazole Dose Finding and Pharmacokinetics in Children and Adults
This study is a single-blind randomized clinical trial conducted in rural Côte d'Ivoire. This study aims at providing evidence on the dose-response of increasing oral albendazole dosages against whipworm (T.
- Trial name
- NCT03527745
- Testing
- Albendazole
- Where
- Côte d’Ivoire
- Volunteers
- 700 people
- Sponsor
- Jennifer Keiser
Helminth Infections
A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants
The purpose of this study is to evaluate the efficacy and safety of mebendazole compared with placebo in pediatric participants with Helminth infections.
- Trial name
- NCT02034162
- Testing
- Mebendazole
- Where
- 3 sites in Ethiopia, Rwanda
- Volunteers
- 295 people
- Sponsor
- Janssen Research & Development, LLC
Ascaris Lumbricoides Infection, Necator Americanus Infection
Cement flooRs AnD chiLd hEalth (CRADLE)
This randomized trial in rural Bangladesh will measure whether installing concrete floors in households with soil floors reduces child enteric infection.
- Conditions
- Ascaris Lumbricoides Infection, Necator Americanus Infection, Trichuris Trichiura; Infection, Diarrhea
- Trial name
- NCT05372068
- Testing
- Concrete household floor
- Where
- Bangladesh
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Stanford University
Trichuriasis
Efficacy of Ivermectin-albendazole vs Albendazole Alone in School-aged Children Infected With Trichuris Trichiura
The goal of this parallel open-label randomized controlled superiority trial is to demonstrate that co-administered ivermectin (200 µg/kg) plus albendazole (400 mg) is superior to albendazole (400 mg) monotherapy in terms of cure…
- Trial name
- FACEITeffic (NCT06037876)
- Testing
- IVM (200 µg/kg) + ALB (400 mg), ALB (400mg)
- Where
- Uganda
- Volunteers
- 161 people
- Sponsor
- Jennifer Keiser
Infections
Education Intervention to Reduce Helminth Infections and Absenteeism in Grade 5 School-children
To efficiently control soil-transmitted helminths (Ascaris, Trichuris, and hookworm), WHO, PAHO, and others recommend the inclusion of an education strategy in school-based deworming programs.
- Trial name
- NCT01085799
- Testing
- Health Education Intervention
- Where
- Peru
- Volunteers
- 1,101 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Helminthiasis
Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults
The aim of this study is to provide data on the efficacy of oxfendazole against Trichuris trichiura at different doses in comparison to the standard single 400 mg dose of albendazole.
- Trial name
- NCT02636803
- Testing
- oxfendazole, albendazole
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Infection by Trichuris Trichiura
The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia
The major soil-transmitted helminths (STHs), Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and Necator americanus/Ancylostoma duodenal (hookworms) are amongst the most prevalent parasites worldwide.
- Trial name
- NCT01327469
- Testing
- Albendazole, 2 x 400mg, Albendazole 400mg, Mebendazole 500mg
- Where
- Ethiopia
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- University Ghent
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Siargao (NCT06800248)
- Testing
- emodepside (BAY 44-4400), Mebendazole 100 MG
- Where
- Philippines
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Trichuriasis, Ascariasis
Efficacy, Safety and Acceptability of Ivermectin ODT in PSAC
This study is a single-blind randomized controlled dose-ranging trial aiming at providing evidence on the on the optimal dose of co-administered ivermectin and albendazole in terms of efficacy, safety and acceptability in…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Iverped (NCT06184399)
- Testing
- Ivermectin 1.5 mg ODT, Ivermectin 3 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 260 people
- Sponsor
- Jennifer Keiser