Clinical trials: Zika Virus Infection
Fever, Dengue
Cohort of Patients Infected by an Arbovirus
There are hundred of arbovirus which have been shown to cause disease in humans. Their most common clinical symptoms are algo-eruptive (dengue, chikungunya, zika), hemorrhagic fever (dengue, yellow fever, Crimean-Congo…
- Conditions
- Fever, Dengue, Chikungunya, Zika Virus
- Trial name
- CARBO (NCT01099852)
- Testing
- biological sample collection, Quality of life Questionnaire EuroQol®, Health Assessment Questionnaire - MDHAQ and RAPID3
- Where
- 8 sites in France, French Guiana and 3 more
- Volunteers
- 1,377 people
- Sponsor
- University Hospital Center of Martinique
Zika Virus
Evaluation of Medical Conditions Associated With Zika Virus Infection in Managua, Nicaragua
Zika virus (ZIKV) infection spread throughout the Americas with devastating consequences. Recent limited evidence suggests the potential for neurological effects associated with postnatally acquired ZIKV infection in humans…
- Trial name
- NCT04182685
- Where
- Nicaragua
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- RTI International
Zika Virus, Zika Virus Infection
VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents
This was a multicenter, randomized study to evaluate the safety, immunogenicity, and efficacy of VRC-ZKADNA090-00-VP (Zika virus wildtype DNA vaccine) or placebo.
- Conditions
- Zika Virus, Zika Virus Infection, Virus Diseases, Flavivirus Infections
- Trial name
- DNA (NCT03110770)
- Testing
- VRC-ZKADNA090-00-VP, VRC-PBSPLA043-00-VP
- Where
- 17 sites in United States, Brazil and 7 more
- Volunteers
- 2,428 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dengue, Vector Borne Diseases
Sustainable Reduction of Dengue in Colombia: Vector Breeding Site Intervention With an Insecticidal Coating
Effective control of Aedes aegypti mosquitoes in breeding sites with high reproductive rates could have a major impact on reducing arbovirosis in endemic communities.
- Conditions
- Dengue, Vector Borne Diseases, Arbovirus Infections, Zika
- Trial name
- NCT06268691
- Testing
- Insecticide Coating INESFLY
- Where
- 2 sites in Colombia, Germany
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Rocio Cardenas Sanchez
Dengue, Zika
Testing Combined IIT-SIT to Control Mosquito-Borne Diseases At Scale
Mosquito-borne diseases cause suffering for hundreds of millions of people and claim more than 700,000 lives yearly. Diseases such as dengue, Zika, and chikungunya cause symptoms similar to malaria and are endemic in many parts…
- Conditions
- Dengue, Zika, Chikungunya
- Trial name
- NCT06595745
- Testing
- Wolbachia induced incompatible mating, Standard traditional chemical mosquito control
- Where
- Mexico
- Volunteers
- 15,243 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Zika Virus
Effect of a Posture Adapter for 12 to 24-month Children With Zyka Virus Syndrome
Congenital Zika virus syndrome (SCZv) has been gaining attention in studies due to changes in the central nervous system and in the motor development of children.
- Trial name
- NCT03227601
- Testing
- posture adapter
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Malaria Fever, Zika
Xpert® Tropical Fever Test on GeneXpert® Edge X System
This is a multi-site, observational, cross-sectional clinical study that includes geographically diverse sites within and outside the United States.
- Conditions
- Malaria Fever, Zika, Dengue Fever, Leptospirosis
- Trial name
- NCT07520279
- Testing
- Xpert Tropical Fever test
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Cepheid
Dengue, Zika Virus Infection
Applying Wolbachia to Eliminate Dengue
This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia
- Conditions
- Dengue, Zika Virus Infection, Chikungunya Fever
- Trial name
- AWED (NCT03055585)
- Testing
- Wolbachia-infected Aedes aegypti mosquitoes, standard practice dengue control
- Where
- Indonesia
- Volunteers
- 8,173 people
- Sponsor
- Gadjah Mada University
Arbovirus Infections
Spatial Repellents for Arbovirus Control
Dengue viruses are the most medically important arthropod-borne pathogens worldwide, with transmission occurring in most tropical and sub-tropical regions. An estimated 390 million infections occur yearly.
- Trial name
- NCT03553277
- Testing
- transfluthrin
- Where
- Peru
- Volunteers
- 18,240 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Aedes-borne Diseases, Dengue
Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases
The objective of this trial is evaluate the efficacy of Targeted Indoor Residual Spraying (TIRS) in preventing symptomatic disease caused by Aedes-borne diseases (ABDs) in children 2 to 15 years of age in the city of Merida…
- Conditions
- Aedes-borne Diseases, Dengue, Chikungunya, Zika
- Trial name
- NCT04343521
- Testing
- Targeted Indoor Residual Spraying (TIRS)
- Where
- Mexico
- Volunteers
- 4,461 people
- Sponsor
- Emory University
Zika Virus Infection
Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection
Introduction: It is estimated that more than one million Brazilians were infected by zika virus in the last two years. Brazilian researchers first noted the virus's potential association with microcephaly.
- Trial name
- NCT03679728
- Testing
- First trimester, Second trimester
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Zika Virus, Congenital Zika Syndrome
Neurodevelopmental Outcomes in ZIKV-Exposed Children
In this study the investigators will follow the neurodevelopmental outcome of children with in utero ZIKV exposure who do not have microcephaly or severe abnormalities consistent with Congenital Zika Syndrome.
- Conditions
- Zika Virus, Congenital Zika Syndrome, Congenital Infection, Child Development
- Trial name
- NCT04398901
- Testing
- Neurodevelopmental assessments
- Where
- 2 sites in United States, Colombia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
HIV, Zika Virus
Prospective Cohort Study of HIV and Zika in Infants and Pregnancy
The purpose of this study is to compare the incidence of Zika virus (ZIKV) infection among pregnant women with and without Human Immunodeficiency Virus (HIV) infection and to determine the risk of adverse maternal and child…
- Conditions
- HIV, Zika Virus, Pregnant Women
- Trial name
- HIV ZIP (NCT03263195)
- Where
- 11 sites in United States, Brazil and 1 more
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Westat
Arbovirus Infections
Spatial Repellents for Aedes-borne Virus Control in Sri Lanka
The primary objective of the study is to demonstrate and quantify the protective efficacy (PE) of a single SR product, in reducing DENV infection and active Aedes-borne virus (ABV) disease in human cohorts.
- Trial name
- AEGIS ABV (NCT05452447)
- Testing
- Transfluthrin
- Where
- 2 sites in Sri Lanka
- Volunteers
- 6,949 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Zika Virus
Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection
In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection.
- Trial name
- NCT02979938
- Testing
- Semen analysis and semen PCR for Zika virus
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- Trinidad and Tobago IVF and Fertility Centre
ZIKA VIRUS INFECTION, Child Development
Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
The recent increase in the number of cases of congenital microcephaly observed in Brazil is a reason of great concern. This increase occurred a few months after Zika virus (ZIKV) was introduced in the country, which was…
- Conditions
- ZIKA VIRUS INFECTION, Child Development, Microcephaly
- Trial name
- ZIKVIRUSIFF (NCT03255369)
- Testing
- Child exposed Zika virus proved
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Oswaldo Cruz Foundation
Microcephaly, Mental Retardation
Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
This prospective cohort study will determine the natural history of fetal exposure to Zika virus (ZIKV) and its effects on the fetus and newborn with emphasis on neurodevelopment outcome.
- Trial name
- ZENI (NCT02943304)
- Testing
- Symptomatic pregnant women with positive RT-PCR ZIKV in serum or urine, or a positive serologic test specific for ZIKV
- Where
- Colombia
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Universidad Industrial de Santander
Congenital Zika Syndrome
Impacts of a Physical Therapy Protocol on Motor Function in Children With Congenital Zika Syndrome
The study aims to evaluate the effects of a specialized physiotherapy protocol aimed at the motor function of children with Congenital Zika Virus Syndrome.
- Trial name
- NCT06900322
- Testing
- Experimental Group (stimuli and handling; physical therapy [PediaSuit]), control group (conventional physical therapy)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Gabriela Lopes Gama
Zika Virus Disease (Disorder), Dengue
The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico
This study will evaluate subjects with fever and/or rash to determine the percentage of those infected by the Zika, Chikungunya, or Dengue virus.
- Conditions
- Zika Virus Disease (Disorder), Dengue, Chikungunya
- Trial name
- Zik01 (NCT02831699)
- Where
- 6 sites in Mexico
- Volunteers
- 600 people
- Sponsor
- Mexican Emerging Infectious Diseases Clinical Research Network
Zika Virus Infection, Microcephaly
Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome
Microcephaly associated with Congenital Syndrome of the Zika virus (SCVZ) was highlighted due to atypical structural and behavioral changes of the central nervous system.
- Trial name
- NCT03330600
- Testing
- aquatic physicotherapy, immersion
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Universidade Federal de Pernambuco