Clinical trials: bipolar
Bipolar Disorder
Study of Aripiprazole (Abilify) in Children With Symptoms of Mania
The purpose of this study is to look at the safety and effectiveness of aripiprazole (abilify) in children with bipolar disorder and to examine whether or not patients that respond to initial mood stabilization benefit from…
- Trial name
- NCT00194077
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Anxiety, Bipolar Disorder
Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
Children who have parents with bipolar disorder are at risk for developing anxiety disorders.
- Trial name
- Mindfulness (NCT02090595)
- Testing
- MBCT-C, Waitlist Control
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Involutional Depression
Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial
This study will examine the effectiveness of omega-3 fatty acids, compounds found in plants and fish, in treating bipolar disorder. Some studies have indicated that omega-3 fatty acids may be effective in treating mood disorders.
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001146
- Testing
- Ethyl Eicosapentaenoic Acid, OmegaBrite
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Mental Health (NIMH)
Abdominal Hysterectomy for Benign Disease
Electrosurgical Bipolar Plasmakinetic Vessel Sealing During Abdominal Hysterectomy: A Randomized Controlled Trial
Objective: To compare the safety and efficacy of the use of bipolar plasmakinetic vessel sealing (Gyrus Pk) usage versus standard technique when performing total abdominal hysterectomy for benign disease.
- Trial name
- PKAHRCT (NCT00654849)
- Testing
- Plasmakinetic bipolar energy forceps, Abdominal Hysterectomy with traditional suture technique
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Hospital de Concentracion Norte de Petroleos
Trigeminal Neuralgia, Refractory Pain
Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia
A prospective exploratory study aiming at comparing pulsed bipolar versus pulsed unipolar radiofrequency ablation in patients with medically refractory trigeminal neuralgia.
- Trial name
- NCT06779578
- Testing
- Bipolar pulsed radiofrequency, Mopolar pulsed radiofrequency
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Mood Disorder, Mental Disorder Diagnosed in Childhood
A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood Dysregulation
Severe mood dysregulation (SMD) is a very common syndrome in children. Its symptoms include very severe irritability, including persistent anger and frequent outbursts, as well as distractibility, hyperactivity, and other…
- Conditions
- Mood Disorder, Mental Disorder Diagnosed in Childhood, Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT00794040
- Testing
- Add-on citalopram following optimized methylphenidate
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, NOS
Brain Connectivity and Mindfulness Training in Youth With Bipolar Disorder Not Otherwise Specified (NOS)
The investigators propose to study 30 adolescents with bipolar disorder, not otherwise specified (BD NOS) and a family history of Bipolar I Disorder (BD) at baseline with rs-fMRI (functional magnetic resonance imaging) and…
- Trial name
- NCT02435225
- Testing
- Mindfulness Based Stress Reduction for Teens Group
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Educational Problems, Anxiety and Fear
Standard Patient Simulation in Nursing Students' Approach Toward Patients With Bipolar Disorder
The study was conducted to determine the effect of the simulation method with the participation of standardized patients towards the patients suffering from bipolar disorder to benefit the education of the psychiatry nursing…
- Conditions
- Educational Problems, Anxiety and Fear, Nurse-Patient Relations
- Trial name
- NCT04027933
- Testing
- Education Based on Standard Patient Simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Bipolar Disorder, Cannabis-Related Disorder
Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
The objectives of this study are to determine whether this treatment may be useful for reducing cannabis consumption; reducing symptoms of bipolar mania; and weight mitigation therapy for individuals on psychopharmacotherapy.
- Trial name
- NCT00393978
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder, Bipolar Disorder, Mixed
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mixed, Affective; Disorder, Organic
- Trial name
- CLASS-BD (NCT05480150)
- Testing
- Escitalopram Oxalate Tablets, Quetiapine Fumarate Tablets, Lurasidone
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bipolar Disorder
Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders
The primary aim of this proposal is to conduct a preliminary controlled trial of valproate and risperidone in children ages 3-7 yr. with bipolar disorders.
- Trial name
- NCT00221403
- Testing
- Risperidone oral solution, Valproate Oral Solution
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bipolar Disorder Depression, Major Depression
AI-based Multi-center Research on Identification/Classification/Aided Diagnosis of Mood Disorder
At present, diagnosis and recognition of depression and bipolar disorder are mainly based on subjective evidence such as clinical interview and scale evaluation.
- Trial name
- NCT05608135
- Where
- China
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Schizophrenia and Disorders With Psychotic Features, Affective Psychosis, Bipolar
Duration of Untreated Psychosis (DUP) and Pathways to Care in Nordland
During the 1990s, evidence began to emerge of the long duration of untreated illness prior to receiving treatment for patients with psychotic disorders.
- Conditions
- Schizophrenia and Disorders With Psychotic Features, Affective Psychosis, Bipolar, Psychoses
- Trial name
- NCT01196858
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- University Hospital of North Norway
Bipolar Disorder
Efficacy and Safety of Task-activated rTMS in Improving Cognitive Function in Patients With Bipolar Disorder
1. To clarify the efficacy and safety of task-based repetitive transcranial magnetic stimulation (rTMS) on cognitive function in patients with stable bipolar disorder. 2.
- Trial name
- NCT06782763
- Testing
- Repetitive transcranial magnetic stimulation device
- Where
- China
- Volunteers
- 82 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bipolar I Disorder
Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode
Hypothesis: Continuation of an atypical antipsychotic medication in combination with a Mood Stabilizer, following remission from an acute manic episode, lowers the rates of relapse and recurrence of mood episodes compared to…
- Trial name
- NCT01977300
- Testing
- Valproate, Lithium, Risperidone
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- University of British Columbia
Adolescent, Bipolar Depression
HD-tDCS for Adolescent Bipolar Depression Targeting S1
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy and underlying biological mechanisms of HD-tDCS targeting the primary somatosensory cortex in adolescents with bipolar depression.
- Conditions
- Adolescent, Bipolar Depression, tDCS, Primary Somatosensory Cortex
- Trial name
- NCT07246044
- Testing
- Active HD-tDCS, Antipsychotics, mood stabilizers, etc.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Bipolar Disorder
Functional and Neurochemical Brain Changes in First-episode Bipolar Mania
The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in people with bipolar disorder who are being treated with either quetiapine or lithium.
- Trial name
- NCT00609193
- Testing
- lithium, quetiapine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Cincinnati
Hyperprolactinemia, Weight Gain
Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia
This is a prospective, open-label study to evaluate the efficacy and safety in reducing antipsychotic-induced hyperprolactinemia, weight gain, and dyslipidemia by aripiprazole.
- Conditions
- Hyperprolactinemia, Weight Gain, Dyslipidemia
- Trial name
- NCT00541554
- Testing
- Abilify (aripiprazole)
- Sponsor
- Genovate Biotechnology Co., Ltd.,
Pediatric Bipolar Spectrum Disorders
Inositol and Omega-3 Fatty Acids in Pediatric Mania
The purpose of this study is to a) evaluate the efficacy of omega-3 fatty acids versus inositol in the treatment of pediatric bipolar disorder, b) evaluate the efficacy of omega-3 fatty acid plus inositol in the treatment of…
- Trial name
- NCT01396486
- Testing
- Omega-3, Inositol
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton