Clinical trials: completed, in Kenya
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KLU156 in Adults and Children With Uncomplicated P. Falciparum Malaria
This study aimed to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for…
- Trial name
- KALUMA (NCT05842954)
- Testing
- KLU156, Coartem
- Where
- 32 sites in Burkina Faso, Côte d’Ivoire and 10 more
- Volunteers
- 1,720 people
- Sponsor
- Novartis Pharmaceuticals
Severe Malaria, Severe Anemia
PDMC Implementation Trial in Kenya
The goal of this implementation trial is to evaluate at least two alternative delivery strategies and adherence support for malaria chemoprevention with dihydroartemisinin-piperaquine in the post-discharge management of children…
- Trial name
- PDMC-SL (NCT06624631)
- Testing
- SMS reminders; adherence support strategy a, Community Health Promoters (CHP) home visits; adherence support strategy b, No reminders; adherence support strategy c
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Liverpool School of Tropical Medicine
Diarrhoea
A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants
This study evaluates the immune response and safety of a multicomponent, 2-dose Shigella vaccine in preventing shigellosis in African infants.
- Trial name
- NCT06663436
- Testing
- altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stress, Psychological, Maternal Health
Caring for Providers to Improve Patient Experience (CPIPE) Trial
The activities described in this proposal are aimed at addressing health care provider stress and unconscious bias to improve quality of maternal health care, particularly related to the person-centered dimensions of care-i.e.
- Conditions
- Stress, Psychological, Maternal Health, Healthcare Provider, Adverse Outcomes
- Trial name
- CPIPE (NCT06085105)
- Testing
- CPIPE Training, Peer support groups, Mentorship
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 6,379 people
- Sponsor
- University of California, San Francisco
HIV
SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension
The overall purpose of this SEARCH CAB-LA (Cabotegravir Injectable Suspension) randomized extension study is to determine if adding the option of CAB-LA as a prevention choice using a person-centered dynamic choice HIV (human…
- Trial name
- NCT05549726
- Testing
- Cabotegravir Injectable Suspension, Dynamic Choice Delivery Model, Standard of Care
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Uncomplicated Plasmodium Falciparum Malaria
Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort B1)
This is Cohort B1 of the Platform study (NCT05750628) to evaluate the efficacy and safety of INE963 + Cipargamin in participants with uncomplicated Plasmodium falciparum malaria.
- Trial name
- PLATINUM (NCT07811882)
- Testing
- KAE609 (Cipargamin), SoC (Coartem), INE963
- Where
- 13 sites in Burkina Faso, Côte d’Ivoire and 5 more
- Volunteers
- 95 people
- Sponsor
- Novartis Pharmaceuticals
COVID-19
Evaluation of the Integration of Ag-RDTs for COVID-19 in MNCH, HIV and TB Services in Cameroon and Kenya
In many national Coronavirus Disease 2019 (COVID-19) response plans, including in Kenya and Cameroon, antigen detection tests are being used to improve access for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
- Trial name
- NCT05498727
- Testing
- Integration of SARS-CoV 2 Testing in HIV, MNCH and TB Clinics
- Where
- 2 sites in Cameroon, Kenya
- Volunteers
- 527,184 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV, HIV Infections
Mobile Phone Technology for Prevention of Mother-to-Child Transmission of HIV: Acceptability, Effectiveness, and Cost (Kenya)
Although gains have been made in achieving the health-related Millennium Development Goals (MDG), much is still needed in countries affected by high levels of HIV/AIDS.
- Conditions
- HIV, HIV Infections, AIDS, Antiretroviral Therapy
- Trial name
- NCT01645865
- Testing
- Control, Intervention
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV/AIDS
Characteristics and Outcomes of Patients Who Received Etravirine and/or Darunavir
The objectives of this data collection activity are to: 1. Describe the baseline demographics, clinical and laboratory profile of patients who ever received darunavir (DRV) and/or etravirine (ETR), at the time of initiation on…
- Trial name
- NewHorizon (NCT04194021)
- Where
- 5 sites in Cameroon, Eswatini and 3 more
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Lung Cancer, Breast Cancer
Observational Study Evaluate Pathology Practice Use Artificial Intelligence in Patient Suspected Lung and Breast Cancer
A multinational observational study to evaluate the current pathology practices and the utilization of computational pathology plus artificial intelligence algorithms in patients with suspected lung and breast cancer.
- Trial name
- CASCADE (NCT06827132)
- Where
- 2 sites in Brazil, Kenya
- Volunteers
- 603 people
- Sponsor
- AstraZeneca
Hiv, AIDS
ALHIV Smartphone Game Study
This is a cluster-randomized controlled trial that aims to conduct comprehensive feasibility testing of a smartphone game in a sample of 120 adolescents living with HIV (ALHIV) ages 15-21 in Kisumu, Kenya, to determine whether…
- Conditions
- Hiv, AIDS, Adolescent Behavior, Treatment Compliance
- Trial name
- NCT06913660
- Testing
- MyGoals, Standard of care
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- Emory University
Severe Acute Malnutrition, HIV
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM
Malnutrition underlies 45% of child deaths, and has far-reaching educational, economic and health consequences. Severe acute malnutrition (SAM) affects 17 million children globally and is the most life-threatening form of…
- Conditions
- Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition
- Trial name
- Co-SAM (NCT05994742)
- Testing
- Rifampicin, Azithromycin, Isoniazid
- Where
- 9 sites in Kenya, Zambia and 1 more
- Volunteers
- 674 people
- Sponsor
- Queen Mary University of London
Human Papillomavirus Vaccination, Cervical Cancer Prevention
Integrating HPV Education Into School Health Programs in Cambodia and Kenya
The Clinton Health Access Initiative conducted a mixed-methods, school-based interventional study in Cambodia and Kenya to evaluate whether integrating age-appropriate human papillomavirus (HPV) education into existing school…
- Trial name
- NCT07784283
- Testing
- Integrated HPV Education
- Where
- 5 sites in Cambodia, Kenya
- Volunteers
- 9,054 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.
Bacterial Vaginosis, Vaginal Microbiome
Single Arm Trial of Menstrual Cups Among Economically Vulnerable Women to Reduce Bacterial Vaginosis and STIs
HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29% of the poorest women have HIV.
- Conditions
- Bacterial Vaginosis, Vaginal Microbiome, Chlamydia Trachomatis Infection, Neisseria Gonorrheae Infection
- Trial name
- POWWERHealth (NCT05666778)
- Testing
- Menstrual Cup
- Where
- 2 sites in United States, Kenya
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Malaria in Pregnancy, Pregnancy Related
MiMBa Pregnancy Registry
The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester.
- Conditions
- Malaria in Pregnancy, Pregnancy Related, Congenital Anomaly
- Trial name
- NCT04825782
- Where
- 2 sites in Burkina Faso, Kenya
- Volunteers
- 15,391 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
IPV, HIV
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
This study will test the effectiveness of a youth-designed multilevel intervention, Tu'Washindi, to increase PrEP use and reduce intimate partner violence (IPV) among Kenyan AGYW and to identify implementation challenges and…
- Conditions
- IPV, HIV, PrEP
- Trial name
- NCT05599581
- Testing
- Tu'Washindi
- Where
- 2 sites in Kenya
- Volunteers
- 1,562 people, healthy volunteers welcome
- Sponsor
- RTI International
Shigellosis
Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants.
In this study, the second-generation tetravalent bioconjugate candidate vaccine Shigella4V2 will be tested to confirm data on its safety and immunogenicity in infants and to identify the best dose of Shigella4V2 in 9-month-old…
- Trial name
- S4V02 (NCT06523231)
- Testing
- Shigella4V2, MenACWY
- Where
- Kenya
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Autism
Expanding Autism Diagnostic Biomarkers to Kenya
The study will use a non-invasive remote eye-tracking system (Eyelink Portable Duo) to acquire a short series of eye-tracking measures.
- Trial name
- KinleyET (NCT06685822)
- Testing
- Eyelink Portable Duo
- Where
- Kenya
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Violence, Domestic, Violence, Sexual
Dissemination and Implementation of a Web-based Relationship Safety App, myPlanKenya, for Women at Risk for Intimate Partner Violence in Nairobi, Kenya
This effectiveness-implementation hybrid-3 study evaluates dissemination, implementation, and effectiveness of myPlanKenya. myPlanKenya will be disseminated through formal and informal sectors.
- Conditions
- Violence, Domestic, Violence, Sexual, Violence, Gender-Based
- Trial name
- myPlanKenya (NCT05609786)
- Testing
- Personalized safety planning tool
- Where
- Kenya
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Observational Study
Assessing the Feasibility and Acceptability of Watching Queen of Katwe as a Role Model Intervention Among Adolescents in High Schools in Kenya
This study will test whether using the film Queen of Katwe as a role model story can help motivate and engage high school students in Kenya.
- Trial name
- NCT07072741
- Where
- 2 sites in Kenya
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Shamiri Institute