Clinical trials: Conventional therapy
Childhood Cancer, Childhood Solid Tumor
Precision Medicine for Every Child With Cancer
To improve outcomes for childhood cancer patients through the implementation of precision medicine.
- Conditions
- Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor, Childhood Leukemia
- Trial name
- ZERO2 (NCT05504772)
- Testing
- Whole Genome Sequencing, RNA seq, DNA Methylation
- Where
- 11 sites in Australia, New Zealand
- Volunteers
- 3,500 people
- Sponsor
- Australian & New Zealand Children's Haematology/Oncology Group
Brain and Central Nervous System Tumors
Combination Chemotherapy in Treating Children With Astrocytomas and Primitive Neuroectodermal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002463
- Testing
- MOPP Regimen, Leucovorin Calcium, Mechlorethamine Hydrochloride
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Stroke (CVA) or TIA, Stroke Recurrence
NORA-HOME: An Ambulatory Multimodal Monitoring Model In Patients With Minor Stroke And Transient Ischemic Attacks
In this project, we aim to validate a Home Hospitalization plan for patients with TIA or minor stroke. Our hypothesis is that our Multimodal Home Hospitalization program (NORAHOME) for patients with TIA and minor stroke is safe…
- Trial name
- NORAHOME (NCT07500116)
- Testing
- Home hospitalization
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Molar Incisor Hypomineralization
Sealants in Molars Affected by Molar-Incisor Hypomineralization
Aim: To evaluate the clinical survival of fluoride sealants applied in first permanent molars affected by Molar-Incisor Hypomineralization (MIH).
- Trial name
- NCT02794116
- Testing
- Conventional Sealants, Resin Sealants
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Paraná
Randomized Clinical Trial
Clinical and Radiographic Outcome of Regeneration in Immature Permanent Human Teeth Using a New Scaffold
This study aimed to evaluate clinical and radiographic outcome of regeneration in immature permanent human teeth using two different types of scaffolds: 1. Collagen-hydroxyapatite scaffold (Osteon III collagen) after blood clot.
- Trial name
- NCT06812351
- Testing
- Osteon III collagen, Blood clot
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Varicose Veins
Microwave Venous Ablation in Comparison to Radiofrequency Ablation, Laser Ablation and Surgical Ligation in Management of Great Saphenous Vein Incompetence
The authors will aim to compare microwave therapy with other lines of management radio-frequency ablation, Laser ablation and surgical ligation; regarding time to recurrence rate, ulcer-free time, and health-related quality of…
- Trial name
- NCT04479956
- Testing
- Varicose vein surgery
- Where
- 2 sites in Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Obstetric Brachial Plexus Injury
The Effects of Virtual Reality Patients With Obstetric Brachial Plexus Injury
Obstetric brachial plexus injury is the flask paralysis of the arm, which emerges from a difficult birth. This results from the damage to the nerves from the C5 cervical root to T1.
- Trial name
- NCT04605601
- Testing
- Virtual reality treatment, conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Emine Atıcı
Hypertension, Osteonecrosis
Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma
This is a randomized unblinded Phase II clinical trial evaluating the impact of intensive antihypertensive control (targeted to the 50-75th percentile for age, sex, and height) compared to conventional antihypertensive control…
- Conditions
- Hypertension, Osteonecrosis, Osteonecrosis Due to Drug
- Trial name
- NCT04401267
- Testing
- Intensive Antihypertensive Therapy, Conventional Antihypertensive Therapy, Symptom Survey
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Children's Dental Fear
QCC Intervention for Dental Fear in Preschool Children: A Non-Randomized Controlled Trial
Management of children's dental fear (CDF) typically relies on conventional one-on-one isolated behavioral interventions delivered by individual clinicians at the chairside.
- Trial name
- QCC (NCT07896551)
- Testing
- Quality Control Circle Intervention, Usual dental care
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Army Medical University, China
Nursing, Skill Performance
Development and Implementation Haptic VR Simulation
The goal of this experimental study is to increase objectivity in clinical decision-making and skill assessment of nursing students by using haptic-assisted virtual reality simulation, unlike imported products used in nursing…
- Conditions
- Nursing, Skill Performance, Virtual Reality, Simulation-based Training
- Trial name
- VR (NCT07175467)
- Testing
- Haptic-asissted virtual simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Hyperphosphatemia
Hyperphosphatemia in Children With Chronic Kidney Disease
"Chronic Kidney Disease-Mineral and Bone Disorder " is a systemic disorder of mineral and bone metabolism, due to chronic kidney disease that is manifested by either one or a combination of the following : 1.
- Trial name
- NCT03202407
- Testing
- Calcium acetate and sevelamer hydrochloride
- Volunteers
- 40 people
- Sponsor
- Assiut University
Liver Metastases, Recurrent Colon Cancer
Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Secondary to Colorectal Cancer
Drugs used in chemotherapy, such as capecitabine and oxaliplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer
- Trial name
- NCT00070265
- Testing
- oxaliplatin, capecitabine, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
RDS of Prematurity
NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
The purpose of this study is to determine whether two different strategies of Non Invasive Ventilation (NIV) have different effect on length and failure of NIV support in preterm infants with respiratory distress syndrome (RDS).
- Trial name
- NIV (NCT02259400)
- Testing
- NSIPPV, BiPAP
- Volunteers
- 280 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Autism Spectrum Disorder
Exercise Interventions for Children With Autism Spectrum Disorder
The purpose of this clinical trial is to find out whether exergame and aerobic exercise can improve sleep, movement skills, thinking abilities, and brain activity in children with autism spectrum disorder (ASD).
- Trial name
- NCT07789457
- Testing
- Exergaming, Aerobic exercise, Conventional physical therapy
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- National Taiwan University Hospital
Myopia, Myopia Progressing
BRIGHT-LIGHT: Studying Red Light Therapy for Severe Short-Sightedness or Short-Sightedness That Worsens Despite Standard Treatment
Some children's short-sightedness (myopia) continues to worsen despite treatments such as atropine eye drops, myopia-control spectacles or contact lenses.
- Conditions
- Myopia, Myopia Progressing, Myopia Progression, Light
- Trial name
- BRIGHT LIGHT (NCT07923019)
- Testing
- Repeated low-level red-light (RLRL) therapy, Continued existing myopia treatment strategy
- Where
- 2 sites in Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore National Eye Centre
Head and Neck Cancer
Cetuximab, Carboplatin, and Paclitaxel Followed by Radiation Therapy, With or Without Cisplatin, in Treating Patients With Metastatic Head and Neck Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them.
- Trial name
- NCT00301028
- Testing
- Cetuximab, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Parkinson's Disease
Short Pulse Width DBS in Parkinson's Disease
The aim of this investigation is to explore the effect of reducing conventional pulse width of stimulation on known adverse effects of Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment such as; slurring of speech…
- Trial name
- NCT03417271
- Testing
- Deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Hemiparesis, Unilateral Cerebral Palsy
Effects and Mechanisms of Sensory Afferent Electrostimulation on Upper Limb Function in Patients With Hemiparesis
The goal for this project is to investigate the effects of a 5-week SAES therapy in addition to conventional therapy on both behavioural (sensory and motor) and neurological measures and the underlying mechanisms of treatment…
- Trial name
- SAES (NCT06536634)
- Testing
- SAES, TAU
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Prostate Cancer
Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androgens.
- Trial name
- NCT00055731
- Testing
- bicalutamide, Goserelin Acetate, docetaxel
- Where
- 38 sites in France
- Volunteers
- 413 people
- Sponsor
- UNICANCER
Hemiplegic Cerebral Palsy
Effect of Hand Arm Bimanual Intensive Technique Including Lower Extremity (HABIT-IL) on Hemiplegic Cerebral Palsy
The aim of this study is to determine the functional status of upper extremity using HABIT \& HABIT-ILE. And to compare the effects of HABIT with and without lower extremity technique on functional status of hemiplegic cerebral…
- Trial name
- NCT05358028
- Testing
- Hand Arm Bimanual Intensive Technique including Lower Extremity (HABIT-IL), Hand Arm bimanual intensive Technique (HABIT)
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
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