Clinical trials: Midazolam
Child, Anesthesia Morbidity
A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children.
- Conditions
- Child, Anesthesia Morbidity, Delirium on Emergence
- Trial name
- NCT01680471
- Testing
- Midazolam 0.03mg/kg, Midazolam 0.05mg/kg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Anam Hospital
Endoscopy
Clinical Trial of Oral Midazolam in Pediatric Endoscopy
The objective of our study was to compare the safety and efficacy of oral midazolam during pediatric endoscopy.
- Trial name
- NCT00636428
- Testing
- Midazolam
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University
Electroencephalographic Neonatal Seizures
A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures
The purpose of the study is to evaluate the pharmacokinetics (PK) of brivaracetam (BRV) in neonates who have seizures that are not adequately controlled with previous antiepileptic drug (AED) treatment, and to identify the…
- Trial name
- NCT03325439
- Testing
- Brivaracetam (BRV) intravenous (iv), Brivaracetam (BRV) oral
- Where
- 12 sites in Belgium, Czechia and 5 more
- Volunteers
- 9 people
- Sponsor
- UCB Biopharma SRL
Obesity, Childhood
Wellness Champions for Change
The Wellness Champions for Change (WCC) study aims to reduce pediatric obesity among students who attend schools in Maryland by training teacher and student-led wellness teams to increase opportunities for physical activity and…
- Trial name
- WCC (NCT03432715)
- Testing
- Student Wellness Champions, Teacher Wellness Champions
- Where
- United States
- Volunteers
- 2,773 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Pediatric Emergence Agitation and Pain
Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children?
Preoperative anxiety is characterized by subjective feelings of tension, apprehension, nervousness and worry. In children, preoperative anxiety is reported to result in postoperative negative psychological effects, including…
- Trial name
- NCT00932685
- Testing
- Midazolam, Game Boy
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Brain Diseases
Dexmedetomidine Verses Propofol for Paediatric MRI Brain
MRI though not painful requires deep sedation for children due to the loud noise created. With deep sedation comes respiratory depression so the interest in Dexmedetomidine.
- Trial name
- DPMP (NCT02776189)
- Testing
- Dexmedetomidine, propofol, Midazolam
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Maharashtra University of Health Sciences
Behavior Problem
Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children
The goal of this clinical trial is to learn the effect of dexmedetomidine premedication in postoperative negative behavior changes in children compared to midazolam premedication.
- Trial name
- NCT06417125
- Testing
- Dexmedetomidine Hydrochloride, Midazolam, normal Saline
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Fujian Provincial Hospital
Urinary Stress Incontinence
Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia
The objective was to observe the satisfaction of local anesthesia during the implantation of the TVT-SECUR for the treatment of stress urinary incontinence, with the use of questionnaires completed by the patients, and to…
- Trial name
- NCT00904618
- Testing
- TVT-SECUR - 'Hammock' technique, TVT-SECUR - 'U-Method', Local anesthesia (30 to 40 ml of a mixture of 35 ml of lidocaine 2% and 5 ml of bicarbonate 3%).
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Analgesia
Opioid Free Anesthesia for Laparoscopic Cholecystectomy
The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure.
- Trial name
- NCT06202664
- Testing
- Erector Spinae Block, Opioid Analgesic
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Melanoma, Non-Small-Cell Lung Cancer
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07799933) administered as a single agent and in combination with other study medicines in people with solid tumors.
- Conditions
- Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma
- Trial name
- NCT05355701
- Testing
- PF-07799933, binimetinib, cetuximab
- Where
- 40 sites in United States, Canada and 1 more
- Volunteers
- 103 people
- Sponsor
- Pfizer
Anxiety
Comparison of Usual Care and Distraction (Tablet) in Children 3-5 Years Old
Randomized control trial comparing usual care and distraction (tablet) on anxiety, emergence delirium, sedation/agitation, and vomiting in children 3-5 years old
- Trial name
- NCT05368961
- Testing
- Distraction, Usual care
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pediatric Burns
Virtual Reality MObility for Burn Patients
Background In the acute phase, burn patients undergo several painful procedures. Pediatric burn care procedures conducted in hydrotherapy have been known to generate severe pain intensity and moderate to high levels of anxiety.
- Trial name
- VR-MOBILE (NCT04538573)
- Testing
- Virtual Reality Distraction, Standard Treatment
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Sedation
Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine (DEX) in intubated and mechanically ventilated pediatric intensive care unit (PICU) subjects.
- Trial name
- NCT00875550
- Testing
- Dexmedetomidine, Midazolam, Fentanyl
- Where
- 37 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Emergence Delirium
Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children
Study where children will receive one premedication, either intranasal dexmedetomidine or oral midazolam, to reduce agitation on emergence of anesthesia.
- Trial name
- NCT03171740
- Testing
- Dexmedetomidine, Midazolam oral solution, Oral saline
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Brasilia University Hospital
Cesarean Scar Defect
Double Vers Single in Cesarean Incision
To assess the effect of single versus double layer closure of caesarean scar on the residual myometrium on the short \& intermediate term.
- Trial name
- NCT05276518
- Testing
- Closure of cesarean section incision
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Separation, Family, Separation Anxiety
Use Of Midazolam In Premedication Of Pediatric Patients
: The aim of the study is to compare the effect of intranasal and oral midazolam administered for premedication to children of preschool age on hemodynamic parameters, sedation and separation from parents.
- Trial name
- NCT07021755
- Testing
- midazolam
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pediatric ALL
Pharmacokinetics of Drugs Administered to Children
This is a prospective study of children <21 years of age with the goal of characterizing the PK of drugs administered per standard of care as prescribed by the treating caregiver.
- Trial name
- NCT03481881
- Testing
- Standard of care drug
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Lacerations
A Randomized, Clinical Trial of Oral Midazolam Versus Oral Ketamine for Sedation During Laceration Repair.
Sedation is often needed for young children undergoing minor procedures in the emergency department (ED). Oral midazolam is one of the most commonly used regimens for children undergoing laceration repair but its sedative…
- Trial name
- NCT01925898
- Testing
- Midazolam - active comparator, Experimental Arm: Ketamine
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Failed Moderate Sedation During Procedure
A Comparison of the Sedation During Endoscopy in Children
The primary aim of this study was to investigate the efficiency and safety of midazolam plus ketamine versus fentanyl plus propofol administered to children undergoing UGE and to determine the most appropriate sedation protocol.
- Trial name
- NCT02732132
- Testing
- Ketamine and Midazolam, Propofol and Fentanyl
- Volunteers
- 238 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Children Requiring Sedation to Facilitate Laceration Repair
Volumes of Administration for Intranasal Midazolam
The purpose of this study is to determine exactly how much drug volume should be administered into each nare, so that the drug absorption can be maximized and the amount that runs out of the nose, or is swallowed, is minimized…
- Trial name
- NCT01948908
- Testing
- Intranasal midazolam
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Columbia University